Aberrant Interhemispheric Functional Organization in Children with Dyskinetic Cerebral Palsy

Abstract

Background. Hemispheric asymmetry is one fundamental principle of neuronal organization. Interhemispheric connectivity and lateralization of intrinsic networks in the resting-state brain demonstrate the interhemispheric functional organization and can be affected by disease processes. This study aims to investigate the interhemispheric organization in children with dyskinetic cerebral palsy (DCP) based on resting-state functional MRI (fMRI). Methods. 24 children with DCP and 20 healthy children were included. Voxel-mirrored homotopic connectivity (VMHC) was calculated to detect the interhemispheric connectivity, and the lateralization of the resting-state networks was performed to examine the asymmetry of the intrinsic networks of brain. Results. Decreased interhemispheric connectivity was found at visual, motor, and motor-control related regions in children with DCP, while high cognitive related networks including the central executive network, the frontoparietal network, and the salience network represented decreased asymmetry in children with DCP. Abnormal VMHC in visual areas, as well as the altered lateralization in inferior parietal lobule and supplementary motor area, showed correlation with the gross motor function and activities of daily living in children with DCP. Conclusion. These findings indicate that the interhemispheric functional organization alteration exists in children with DCP, suggesting that abnormal interhemispheric interaction may be a pathophysiological mechanism of motor and cognitive dysfunction of CP.

Imaging Developmental and Interventional Plasticity Following Perinatal Stroke

“…194 A multimodal study in PVI suggested that differences in inter-and intrahemispheric functional connectivity may be CST-wiring specific. 194 Seed-based analyses have indicated that AISs have significantly lower interhemispheric functional connectivity values in sensorimotor cortical regions than peers 195,196 and that PVI show lower functional connectivity for supplementary motor areas compared to peers 196 when seeding the lesioned M1. Higher intrahemispheric functional connectivity in the anterior supramarginal gyrus in the lesioned hemisphere of AIS was also observed compared to both typically developing peers and PVI.…”

Changes of Structural Brain Network Following Repetitive Transcranial Magnetic Stimulation in Children With Bilateral Spastic Cerebral Palsy: A Diffusion Tensor Imaging Study

“…Moreover, previous study with the network-based statistic (NBS) analysis demonstrated that fractional anisotropy (FA) with basal ganglia (mainly putamen and pallidum) and thalamus were significantly reduced in CP children ( 40 ). Gray matter lesions were also found in the basal ganglia of CP children, mainly located in bilateral putamen ( 46 ). The damaged posterior thalamic radiation connecting the thalamus to the posterior parietal and occipital cortex, was found to be associated with motor dysfunction in children with spastic CP ( 47 ).…”

Relationship between resting-state fMRI functional connectivity with motor and language outcome after perinatal brain injury – A systematic review

“…Selected studies were assessed for quality and bias with the application of the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) 26 . * Two 31,32 and three studies [27][28]35 recruited from the same database.…”

“…The 10 studies included in this systematic review comprised 260 individuals with a history of perinatal brain injury (145 [55%] males) and 290 controls (159 [55%] males), with results summarised in Table 2. Of the studies assessing motor outcome, one study assessed whether rs-fMRI at term-equivalent age (TEA) would be predictive of motor impairments at followup at 4 and 8 months of age 29 , and the remaining 6 studies investigated the relationship between rs-fMRI and motor functioning cross-sectionally in individuals between 3 and 19 years of age [27][28][29][30][31][32][33] . 3 studies also assessed the association between rs-fMRI and language performance at the same time-point in individuals between 3 years 6 months and 29 years 1 month [34][35][36] .…”

“…The location of lesions was reported as occurring in left or right-hemispheres, and/or in cortical or subcortical regions. Studies assessing the relationship between resting-state fMRI and motor outcome identified lesions in the basal ganglia 27,31,32 , thalamus 31,32 , internal capsule 28 , white matter [29][30][31]33 , grey matter 29,[31][32] , and IVH 29 , while studies assessing the J o u r n a l P r e -p r o o f relationship between resting-state fMRI and language outcome reported lesions in the thalamus 34 , white matter 34 , temporo-parietal junction 34 , PVL 34 , language related brain regions 36 , and predominantly affecting the left hemisphere [35][36] .…”