Effect of motilin on gastric distension sensitive neurons in arcuate nucleus and gastric motility in rat

Luo, Xu; Gao, Shengli; Guo, Feifei; Sun, Xiangrong

doi:10.1111/j.1365-2982.2010.01661.x

Cited by 16 publications

(8 citation statements)

References 17 publications

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“…Gas O 'Dea, Brookes, & Wattchow, 2010;Shibata et al, 1995;Silkoff et al, 1988;Xu, Gao, Guo, & Sun, 2011) and were found to change after administration with diphenoxylate or water-fasting for 4 days in the present work. Gas was structured with a pair of heptadecapeptide amides and released from the astrin-containing cell (G-cell) in the antropyloric mucosa.…”

Section: Discussionsupporting

confidence: 44%

Character and laxative activity of polysaccharides isolated from Dendrobium officinale

Luo

Qu²,

Lin

et al. 2017

Journal of Functional Foods

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Section: Discussionsupporting

confidence: 44%

Character and laxative activity of polysaccharides isolated from Dendrobium officinale

Luo

Qu²,

Lin

et al. 2017

Journal of Functional Foods

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“…Owing to food intake, gastric volume increases, which causes distension of gastric fundus and transfer afferent information to the ARC (Xu et al . ) or LH (Jeanningros ). Excitement or inhibition of LH neurons may regulate digestive function through efferent descending signals (Zhang et al .…”

Section: Discussionmentioning

confidence: 99%

Lateral hypothalamic Orexin‐A‐ergic projections to the arcuate nucleus modulate gastric function in vivo

Luan

Sun

Guo

et al. 2017

Journal of Neurochemistry

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It has been well-known that hypothalamic orexigenic neuropeptides, orexin-A, and melanin-concentrating hormone (MCH), play important roles in regulation of gastric function. However, what neural pathway mediated by the two neuropeptides affects the gastric function remains unknown. In this study, by way of nucleic stimulation and extracellular recording of single unit electrophysiological properties, we found that electrically stimulating the lateral hypothalamic area (LH) or microinjection of orexin-A into the arcuate nucleus (ARC) excited most gastric distension-responsive neurons in the nuclei and enhanced the gastric function including motility, emptying, and acid secretion of conscious rats. The results indicated that LH-ARC orexin-A-ergic projections may exist and the orexin-A in the ARC affected afferent and efferent signal transmission between ARC and stomach. As expected, combination of retrograde tracing and immunohistochemistry showed that some orexin-A-ergic neurons projected from the LH to the ARC. In addition, microinjection of MCH and its receptor antagonist PMC-3881-PI into the ARC affected the role of orexin-A in the ARC, indicating a possible involvement of the MCH pathway in the orexin-A role. Our findings suggest that there was an orexin-A-ergic pathway between LH and ARC which participated in transmitting information between the central nuclei and the gastrointestinal tract and in regulating the gastric function of rats.

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“…MTL, a polypeptide secreted by Mo cells, induces strong gastrointestinal motility. By contrast, VIP, released from the inhibitory vasoactive intestinal peptidergic fibers, leads to inhibition of gastric acid secretion and relaxation of the gastrointestinal tract25262728. Thus, increasing MTL and decreasing VIP could promote gastrointestinal motility.…”

Section: Discussionmentioning

confidence: 99%

Using the “target constituent removal combined with bioactivity assay” strategy to investigate the optimum arecoline content in charred areca nut

Peng

Liu

et al. 2017

Sci Rep

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Charred areca nut (CAN) is used to treat dyspepsia and abdominal distension in children. However, reports revealed that arecoline, the most important active constituent of CAN, possesses potential toxicities. This study was designed to investigate the optimum arecoline content in CAN, using the “target constituent removal combined with bioactivity assay” strategy. Based on PTLC method, we prepared CAN lacking all arecoline (WAC-100R) and a series of different ratios of arecoline-removed CAN samples (WAC-Rx). MTT and acute toxicity assays indicated that decreasing content by 50% decreased CAN toxicity significantly. Animal results revealed arecoline contents over 50% could guarantee the beneficial effects of CAN on gastrointestinal tract. Additionally, decreasing arecoline content in CAN by 50% decreased its pro-apoptotic effects significantly. Furthermore, decreasing 50% arecoline content in CAN down-regulated the expressions of Cleaved-Caspase-3, c-jun, c-fos, COX-2, PGE2, and IL-1α. Thus, our results revealed that CAN with 50% arecoline content (WAC-50R) has similar beneficial effects on the gastrointestinal tract to CAN, whereas its toxicity was decreased significantly. Collectively, our study suggested that the strategy of “target constituent removal combined with bioactivity assay” is a promising method to identify the optimum arecoline content in CAN, which is approximately 0.12%.

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Effect of motilin on gastric distension sensitive neurons in arcuate nucleus and gastric motility in rat

Cited by 16 publications

References 17 publications

Character and laxative activity of polysaccharides isolated from Dendrobium officinale

Character and laxative activity of polysaccharides isolated from Dendrobium officinale

Lateral hypothalamic Orexin‐A‐ergic projections to the arcuate nucleus modulate gastric function in vivo

Using the “target constituent removal combined with bioactivity assay” strategy to investigate the optimum arecoline content in charred areca nut

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