Effect of motilin and other gut hormones on gall bladder pressure

Adrian, TE; Mitchenere, P.; Sagor, G.R.; Christofides, Nicos; Bloom, S.R.

doi:10.1016/0167-0115(80)90020-8

Cited by 7 publications

(5 citation statements)

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“…Plasma motilin levels were, however, suppressed. Plasma levels of motilin have been found to vary in relation to the interdigestive migrating motor complex in man [41,421, and recently motilin has been reported to increase the tone of the gallbladder in pigs in vivo [43]. Clarification of a possible endocrine or neuroendocrine mechanism for the inhibitory effect of duodenal STC on caerulein/secretin stimulated biliary excretion requires further study.…”

Section: Discussionmentioning

confidence: 99%

Effects of duodenal perfusion with sodium taurocholate on biliary and pancreatic secretion in man

Björnsson

Maton

Fletcher

et al. 1982

Eur J Clin Investigation

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The effects of intraluminal sodium taurocholate (STC) on biliary and pancreatic secretion were studied in man using a duodenal perfusion technique and indocyanine green (ICG) as an exogenous biliary marker. Duodenal perfusion with 15 or 30 mmol/l STC in healthy subjects markedly suppressed caerulein and secretin stimulated biliary indocyanine green (ICG) excretion in a dose responsive manner, i.e. to 40% (17-95%, +/- 2 SD, n = 5) (P less than 0.025) and 32% (26-38%, +/- 2 SD, n = 3) (P less than 0.003) of i.v. ICG infusion, respectively, with a maximum suppression to 26% and 10%, respectively. In cholecystectomized subjects (n = 5), significant changes in ICG excretion were not observed during STC (15 mmol/l) perfusion. There were no suppressive effects on pancreatic enzyme or bicarbonate secretion in any of the subjects. Our observations suggest that the bile salts STC in the duodenum in man activated a mechanism which selectively suppressed biliary excretion. This is probably due to relaxation of the gallbladder and an increase in gallbladder storage of bile.

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Section: Discussionmentioning

confidence: 99%

Effects of duodenal perfusion with sodium taurocholate on biliary and pancreatic secretion in man

Björnsson

Maton

Fletcher

et al. 1982

Eur J Clin Investigation

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“…Although it is widely accepted that cholecystokinin has a physiological hormonal role in stimulating gall-bladder contraction and pancreatic enzyme secretion, some doubt has remained, chiefly because of unreliable earlier estimates of circulating cholecystokinin concentrations. However, exogenous cholecystokinin octapeptide, given at rates resulting in the low rises of plasma concentration now known to be physiological, does cause an increase in gall-bladder pressure in the pig (Adrian et al 1980), and infusions of cholecystokinin-33 and cholecystokinin octapetide on a background of secretin stimulates pancreatic enzyme secretion in man, with a half-maximal response at plasma concentrations of 5-10 pmol/l (Valenzuela et al…”

Section: I985mentioning

confidence: 99%

“…However, exogenous cholecystokinin octapeptide, given at rates resulting in the low rises of plasma concentration now known to be physiological, does cause an increase in gall-bladder pressure in the pig (Adrian et al 1980), and infusions of cholecystokinin-33 and cholecystokinin octapetide on a background of secretin stimulates pancreatic enzyme secretion in man, with a half-maximal response at plasma concentrations of 5-10 pmol/l (Valenzuela et al…”

Section: Kanno Et Al 1979)mentioning

confidence: 99%

The gut hormone response to food

Uttenthal¹

1985

Proc. Nutr. Soc.

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“…motility (Adrian, Mitchenere, Sagor, Christofides & Bloom, 1981). Motilin appears to stimulate gall-bladder contraction whereas pancreatic polypeptide inhibits contraction.…”

Section: Leeds Ls2 9jtmentioning

confidence: 99%

Poster Communications

1982

The Journal of Physiology

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Three different types ofmuscle fibres have been characterized electrophysiologically in frog skeletal muscle: the singly innervated fast twitch muscle fibres and the multiply innervated slow tonic fibres present in muscles like the iliofibularis (Kuffler & Vaughan Williams, 1953) and the multiply innervated twitch muscle fibres of the submaxillaris muscle (Miledi & Uchitel, 1981). We have previously reported (Miledi & Uchitel, 1981) that the mean life-times of synaptic ACh-induced channels in fast, submaxillaris and slow muscle fibres were about 5, 7 and 15 msec respectively and that their single channel conductances were about 16, 14 and 8 pS respectively, when recorded at -90 mV membrane potential and at 6 'C.We have now studied the extrajunctional ACh-induced channels of denervated fast and slow muscle, fibres from the iliofibularis and pyriformis muscles, and ofdenervated muscle fibres of the submaxillaris muscle of the frog. Denervation was performed under ether anaesthesia. The properties of the ACh-induced channels were estimated from the power spectra ofthe current fluctuations induced by ionophoretic application of ACh to a voltage-clamped area of extrajunctional membrane. The muscles were incubated in normal Ringer at 6 'C. The mean life-times of the extrajunctional ACh-induced channels were 15-43 + 0 79 msec (n = 11), 16-64 + 0-78 msec (n = 10) and 15-20 + 0-55 msec (n = 18) in the fast, submaxillaris and slow muscle; and their single channel conductances were 12-12+0-53 pS (n = 9) 11-01 +0-79 pS (n = 10) and 11-73+0-73 pS (n = 12) respectively (membrane potential: -90 mV; values are mean + S E. n = number of muscle fibres).We conclude that, while the different types of muscle fibres have functional channels which differ in their properties, the extrajunctional channels induced by ACh all have similar characteristics. These findings support the hypothesis of a neural control of synaptic channel properties.We are grateful to the Muscular Dystrophy Group of Great Britain for their financial support.

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Effect of motilin and other gut hormones on gall bladder pressure

Cited by 7 publications

References 0 publications

Effects of duodenal perfusion with sodium taurocholate on biliary and pancreatic secretion in man

Effects of duodenal perfusion with sodium taurocholate on biliary and pancreatic secretion in man

The gut hormone response to food

Poster Communications

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