The gut hormone response to food

Uttenthal, L. O.

doi:10.1079/pns19850010

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…Pigs fed on the continuous nutrient level had significantly higher levels of (N -C)-terminal enteroglucagon. An increase in the amount of nutrient reaching the lower gut may have provided the stimulus for the release of this hormone (Utlenthal, 1985). The increases in weight of the ST, of SI mucosa and the greater villous height in the C group may have been attributable to the trophic effects of enteroglucagon, and enhanced secretion of this hormone may be the mechanism whereby gut function alters in response to the level of nutrient intake.…”

Section: R E S U L T Smentioning

confidence: 99%

Digestive development of the early-weaned pig

1991

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Gastric intubation was adopted as a means of comparing the effect of two feeding levels, continuous nutrient supply (C) and restricted nutrient supply (R), on the digestive development of pigs weaned at 14 d of age, during the first 5 d post-weaning. The absolute weights of the stomach and the pancreas were significantly greater (P < 0.001) in C compared with R pigs. The effect was not significant for pancreas weight when expressed per kg body-weight but was significant (P < 0.05) for stomach weight. The weights of the small intestine (SI), SI mucosa and total mucosal protein were significantly higher (P < 0.001) in C pigs but protein content per g mucosa was similar in the C and R groups. There was no significant effect of treatment on the activity of lactase (p-glucosidase; EC 3.2.1.23) or sucrase (sucrose-a-glucosidase; EC 3 . 2 . 1 .48) irrespective of the basis of comparison used. The specific activity (pmol/min per g protein) of maltase (a-glucosidase; EC 3 . 2 . 1 .20) and of glucoamylase (glucan-1,4-aglucosidase; EC 3.2.1.3) were similar in C and R groups but activities of maltase (pmol/g mucosa) (P < 005), and maltase and glucoamylase (mol/d) (P < 0.01) were significantly higher in C pigs. Villous height and crypt depth were significantly greater in C pigs (P < 0.001 and P < 0.05 respectively). Enteroglucagon was significantly (P < 0.05) higher in C compared with R pigs. Xylose absorption and the digestibility of energy were not affected by treatment. Digestibility of dry matter, organic matter, crude protein (nitrogen x 625) and carbohydrate were significantly higher (P < 0@01, P < 0.01, P < 0.05 and P < 0.001 respectively) in R pigs compared with C pigs but the differences were small, ranging from 1.3 to 2.5 %. These results demonstrate that (1) nutrient intake in the weaned pig affects the anatomy, morphology and function of the gut, (2) there is considerable 'spare capacity' for digestion of cereal-based diets even in pigs weaned a t 14 d of age, (3) measurements in vitro of digestive function are of limited value unless supported by information in vivo on absorptionldigestibility.

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Section: R E S U L T Smentioning

confidence: 99%

Digestive development of the early-weaned pig

1991

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“…Food is well known to stimulate the release of pancreatic enzymes. 28,29 Thus, this trend may be due to the gradual initiation of food orally after 1 week of exclusive parenteral nutrition. The initiation of an oral diet on day 18 correlates well with the moderate rise in pancreatic enzyme levels observed at this time.…”

Section: Discussionmentioning

confidence: 99%