Effect of morphine and flunixin meglumine on isoflurane minimum alveolar concentration in goats

Doherty, Thomas J; Will, W.; Rohrbach, Barton W; Geiser, Dvm Dennis R.

doi:10.1111/j.1467-2987.2004.00156.x

Cited by 26 publications

(14 citation statements)

References 18 publications

(33 reference statements)

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“…It was expected that the association of acepromazine to the opioids could provide better sedation, as described in dogs [4], but the data in the present study suggest that these effects may not occur in sheep. Morphine and fentanyl decrease minimal alveolar concentration of isoflurane in goats and ewes, respectively [8, 9], highlighting the sparing capacity effect of opioids in small ruminants, although these aspects were not assessed in this study.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Acepromazine Alone or in Combination with Methadone, Morphine, or Tramadol on Sedation and Selected Cardiopulmonary Variables in Sheep

Nishimura

Villela

Carvalho

et al. 2017

Veterinary Medicine International

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The sedative and selected cardiopulmonary effects of acepromazine alone or in combination with methadone, morphine, or tramadol were compared in sheep. Six ewes were randomly assigned to treatments: A (0.05 mg/kg acepromazine), AM (A plus 0.5 mg/kg methadone), AMO (A plus 0.5 mg/kg morphine), and AT (A plus 5 mg/kg tramadol). Parameters were assessed before sedative drug administration (baseline) and every 15 minutes thereafter, for two hours. Treatments A and AM were associated with increases in sedation score for 60 minutes and treatments AMO and AT for 30 minutes; however, there were no significant differences between treatments. There was a decrease in mean arterial pressure compared to baseline values in treatment A at 15, 45, 60, and 90 minutes, in treatment AM at 15 minutes, and in treatment AT from 45 to 120 minutes. Arterial blood carbon dioxide pressure increased at all time points in all treatments. Arterial oxygen pressure decreased in treatment AMO at 15, 30, and 120 minutes and in treatment AT at 15–45, 105, and 120 minutes, compared to baseline. Acepromazine alone causes a level of sedation similar to that observed when it is coadministered with opioids methadone, morphine, and tramadol. These combinations did not cause clinical cardiopulmonary changes.

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Section: Discussionmentioning

confidence: 99%

The Effect of Acepromazine Alone or in Combination with Methadone, Morphine, or Tramadol on Sedation and Selected Cardiopulmonary Variables in Sheep

Nishimura

Villela

Carvalho

et al. 2017

Veterinary Medicine International

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“…Likewise, there is no information on the effect of fentanyl on the propofol induction and maintenance dose in goats. Morphine, a μ opioid agonist like fentanyl, was reported to decrease isoflurane minimum alveolar concentration by 30% after administration at 2 mg kg -1 as single intravenous dose (Doherty et al 2004.…”

Section: Discussionmentioning

confidence: 99%

“…The doses of fentanyl and midazolam used in this study were chosen on the basis of unpublished studies from the authors' laboratory which showed that these doses reduced isoflurane minimum alveolar concentration (MAC) by about 30%. Fentanyl has been administered to goats IV for its antinociceptive effects (Carroll et al 1999), although (Doherty et al 2004), so fentanyl could be anticipated to provide intra-anaesthetic analgesia. In goats, midazolam causes sedation (Stegmann & Bester 2001;Dzikiti et al 2009) and decreases the induction dose of propofol required (Dzikiti et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Total intravenous anaesthesia (TIVA) with propofol-fentanyl and propofol-midazolam combinations in spontaneously-breathing goats

Dzikiti

Stegmann

Dzikiti

et al. 2010

Veterinary Anaesthesia and Analgesia

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Objective To compare the efficacy and cardiopulmonary effects of propofol and fentanyl, with propofol and midazolam for total intravenous anaesthesia.Study Design Prospective, randomized, crossover experimental study.Animals Six healthy goats; 3 does and 3 wethers. ). MethodsCardiopulmonary function was well maintained with both treatments. Recovery times in minutes from the end of anaesthetic infusion for treatments FP and MP respectively were; to extubation 3.0 (3.0-3.0) and 4.5 (3.3-5.0); to sternal position, 4.5 (3.3-5.0) and 5.0 (5.0-6.5) and to standing 13.0 (10.3-15.0) and 15.0 (11.3-17.3). Quality of recovery was acceptable in both groups, but abnormal behavioural signs were observed after treatment FP. Conclusions and clinical relevanceTotal intravenous anaesthesia with propofol and fentanyl or propofol and midazolam, at the doses studied, in spontaneously-breathing, oxygen-supplemented goats is practicable. Recovery from the fentanyl-propofol combination is not always smooth.

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“…Muir, Wiese and March (2003) observed a 45% reduction of the MAC of isoflurane in dogs using the same solution (MLK) as the present study. In another study using morphine intravenously (2 mg kg -1 ) in goats, Doherty et al (2004) observed a 29.7% reduction of the MAC of isoflurane. In calves, the end-tidal concentration of isoflurane was significantly lower in the group treated with 50 µg kg -1 minute -1 lidocaine, indicating a 16.7% reduction in anesthetic requirement during lidocaine CRI (VESAL et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Effects of the morphine-lidocaine-ketamine combination on cardiopulmonary function and isoflurane sparing in sheep

Beier

Rosa

Oleskovicz³

et al. 2014

Sem. Ci. Agr.

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The aims of this study were to evaluate the isoflurane sparing and clinical effects of a constant rate infusion of morphine -lidocaine -ketamine (MLK) in healthy sheep undergoing experimental gastrointestinal surgery. Twelve adult female sheep (Texel breed) were used, weighing 36.5 ± 8.1 kg. The sheep were anesthetized for the implantation of duodenal cannulas. The sheep were premedicated with 0.3 mg kg -1 intramuscular (IM) morphine and 20 µg kg -1 intravenous (IV) detomidine. After premedication, anesthesia was induced using 5 mg kg -1 ketamine and 0.5 mg kg -1 diazepam IV and maintained using isoflurane in 100% oxygen. After the induction of anesthesia, the animals were allocated into two groups (each n=6); the GMLK (MLK group -10 mg morphine, 150 mg lidocaine, 30 mg de ketamine were added in 500 mL saline) received a 10 mL kg -1 h -1 MLK infusion during the maintenance of anesthesia, and GCON (control group) received 10 mL kg -1 h -1 of 0.9% sodium chloride. The animals were mechanically ventilated. Cardiopulmonary variables and end-tidal isoflurane concentration (FE´Iso) were measured at baseline (immediately before the surgery) and 15, 30 and 45 minutes after initiation of surgery. In GMLK, there was a decrease in the FE´Iso at 15, 30 and 45 minutes, a reduction of up to 75.6% during the surgery. The HR was lower in GMLK compared with GCON at 30 minutes, and the MAP was at during baseline in GCON compared with GMLK. The standing time was less in GMLK than in GCON. The use of intravenous MLK was demonstrated to offer great efficiency as part of a balanced anesthesia protocol in sheep, with a 75.6% reduction in the need for isoflurane, providing stability of the cardiovascular parameters and blood gases with a shortened recovery period. Key words: Sheep, morphine, lidocaine, ketamine, isoflurane ResumoOs objetivos deste estudo foram avaliar a redução na concentração expirada de isoflurano, bem como os efeitos clínicos de uma infusão constante de morfina -lidocaína -cetamina (MLK) em ovinos saudáveis submetidos a cirurgia gastrointestinal experimental. Foram utilizados doze ovinos adultos da raça Texel, fêmeas, pesando 36,5 ± 8,1 kg. Os animais foram anestesiados para implantação de cânulas no duodeno, sendo pré-medicados com morfina 0,3 mg kg -1 , pela via intramuscular (IM), e detomidina 20 ug kg -1 pela via intravenosa (IV). Após a pré-medicação, a anestesia foi induzida com cetamina 5 mg kg -1 e diazepam 0,5 mg kg -1 IV, sendo mantidos com isoflurano em oxigênio a 100%. Após a indução da anestesia os animais foram divididos em dois grupos (n = 6): GMLK (grupo MLK -10 mg de morfina, 150 mg de lidocaína e 30 mg de cetamina foram adicionados em 500 ml de solução salina) que recebeu infusão contínua de MLK na taxa de 10 mL kg

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Effect of morphine and flunixin meglumine on isoflurane minimum alveolar concentration in goats

Cited by 26 publications

References 18 publications

The Effect of Acepromazine Alone or in Combination with Methadone, Morphine, or Tramadol on Sedation and Selected Cardiopulmonary Variables in Sheep

The Effect of Acepromazine Alone or in Combination with Methadone, Morphine, or Tramadol on Sedation and Selected Cardiopulmonary Variables in Sheep

Total intravenous anaesthesia (TIVA) with propofol-fentanyl and propofol-midazolam combinations in spontaneously-breathing goats

Effects of the morphine-lidocaine-ketamine combination on cardiopulmonary function and isoflurane sparing in sheep

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