Effect of Moringa Oleifera on Lipid Profile in Rats

Abstract

Background: Coronary heart disease, stroke, atherosclerosis and hyperlipidemia are primary causes of death worldwide. Moringa Oleifera tree was used as a health supplement introduced to Africa from India. Its leaves have various biological activities, including hypolipidemic effect. Objective(s):The aim of present study was to assess the effect of Moringa Oleifera consumption on lipid profile and histopathology of the liver in hyperlipidemic rats. Methods: A total of 50 male albino rats were divided into five equal groups. Group I was left as control and fed on standard diet only. Group II was fed on standard diet and orally injected with 400 mg/kg of rat body weight extract of Moringa Oleifera. Hyperlipidemia was induced in the remaining 30 rats by feeding an atherogenic diet for four weeks. Group III was fed on atherogenic diet only. Group IV was fed on atherogenic diet and orally injected with 400 mg/kg of rat body weight extract of Moringa Oleifera. Group V was fed on atherogenic diet with 2mg/kg of rat body weight Atorvastatin drug. Lipid profile of rat blood was measured including total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), and very low density lipoprotein (VLDL). Liver tissue was evaluated by carrying out histopathological examination. Results: The rats fed on Moringa Oleifera showed a significant decrease in total cholesterol and LDL by 26.8% and 40.6% respectively compared to baseline values after 4 weeks. Although VLDL and TG showed slight increase by 5.6% and 5.1% respectively, they were still within the normal range. Otherwise, there was a significant increase in LDL, VLDL, TC, and total TG levels in rats fed on atherogenic diet only by 17.13%, 195.4%, 29.2%, and 193% respectively compared to baseline values after 4 weeks. Atorvastatin drug affected the HDL level, as it increased by 16.4% % 28% from baseline after two and four weeks respectively. Atorvastatin and Moringa Oleifera decreased VLDL level by 53.9% & 36.5% respectively when compared to rats fed on atherogenic diet. Conclusion: Moringa Oleifera was comparable to hypolipidemic medication (Atorvastatin) in improving the lipid profile of rats fed on atherogenic diet. Moringa Oleifera intake is more effective in prevention than in treatment of hyperlipidemia.

Studies on Pancreatic Gene Expression in Diabetic Rats Treated with Moringa oleifera Leaf

“…The increased expression of SNAP-23 could be attributed to the activity of the gene in stimulating the release of adiponectins and leptin from the adipocytes. This is in agreement with the investigated evidence by Samar et al [8], who reported that Moringa oleifera reduced total cholesterol, triglyceride, low density cholesterol, high density cholesterol and very low density cholesterol in rats and that it is more effective in prevention of hyperlipidemia. We also found no significant difference in the expression of SNAP25, Kv1.2, and GLP-1R genes among all the rats.…”

التأثیرات الوقائیة للمستخلصات المائیة لأوراق المورینجا والشای الأخضر على الفئران المصابة بارتفاع الکولسترول فی الدم

“…Rats orally preventable administered with aqueous extracts of the mixture of moringa and green tea reflected the highest significant decrease in TC and TG compared to control positive groups which were 98.78±0.12, 90.55±0. These results confirmed by the findings of Aborhyem et al, (2016) who compared Moringa oleifera with atorvastatin as a hypolipidemic drug in improving the lipid profile of mice fed an atherosclerotic diet; concluding that Moringa oleifera caused effective prevention of hyperlipidemia when compared to hypolipidemic drugs. Moreover, Bakr and Header (2014) studied the effect of aqueous green tea extract on obese mice and side effects on their liver condition, which led to a significant decrease in total cholesterol and lipid levels in the green tea-treated groups.…”

Cinnamon Reduces Dyslipidemia and Liver Steatosis Induced by High Fat Diet in Albino Rats: Histological, Ultrastructural, and Biochemical Studies

“…In the present study, several histopathological changes were seen in the liver of HFD-fed animals either for 4 or 8 weeks; the hepatocytes undergo hydropic degeneration and become swollen and vacuolated, described as ballooning degeneration. The previous studies reported that the consumption of HFD may play crucial role in the pathogenesis of fatty liver resulting in hepatocellular damage and exaggerated hepatic steatosis that is associated with other factors such as oxidant stress, mitochondrial injury, fatty acids lipotoxicity, and inflammatory cytokines [19,20]. Tveden-Nyborg et al [21] attributed these changes to the oxidative stress of dyslipidemia that disturbed redox balance resulting in the damage of polyunsaturated lipids in the mitochondrial membrane associated with a reduced export of TG and a subsequent accumulation in hepatocytes.…”