Effect of Moringa Oleifera in Experimental Model of Alzheimer's Disease : Role of Antioxidants

Ganguly, Ranira; Hazra, Rimi; Ray, Kaushik; Guha, Debajani

doi:10.5214/ans.0972.7531.2005.12030

Cited by 14 publications

(19 citation statements)

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“…Previous studies of MS patients have linked hippocampal demyelination to progressive cognitive and memory dysfunction [ 30 ]. M. oleifera treatment after 5 weeks of CPZ diet restored the long and short-term memory in experimental animals, and this is consistent with the report that the leaf extract of M. oleifera improves memory impairment in Wistar rats [ 25 ].…”

Section: Discussionsupporting

confidence: 91%

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Ameliorative effects of Moringa on cuprizone-induced memory decline in rat model of multiple sclerosis

et al. 2018

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Cuprizone is a neurotoxin with copper-chelating ability used in animal model of multiple sclerosis in which oxidative stress has been documented as one of the cascade in the pathogenesis. Moringa oleifera is a phytomedicinal plant with antioxidant and neuroprotective properties. This study aimed at evaluating the ameliorative capability of M. oleifera in cuprizone-induced behavioral and histopathological alterations in the prefrontal cortex and hippocampus of Wistar rats. Four groups of rats were treated with normal saline, cuprizone, M. oleifera and a combination of M. oleifera and cuprizone, for five weeks. The rats were subjected to Morris water maze and Y-maze to assess long and short-term memory respectively. The animals were sacrificed, and brain tissues were removed for histochemical and enzyme lysate immunosorbent assay for catalase, superoxide dismutase, and nitric oxide. Cuprizone significantly induced oxidative and nitrosative stress coupled with memory decline and cortico-hippocampal neuronal deficits; however, administration of M. oleifera significantly reversed the neuropathological deficits induced by cuprizone.

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Section: Discussionsupporting

confidence: 91%

“…The neuroprotective effect of M. oleifera extracts was also investigated in animal models of neurodegeneration [ 18 ]. In addition, M. oleifera leaf extract improves memory impairment and provides significant antioxidants to counteract oxidative stress in rats [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Ameliorative effects of Moringa on cuprizone-induced memory decline in rat model of multiple sclerosis

et al. 2018

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“…It is recognized that the monoaminegistic system has a modulatory role in memory processing and that this system is disturbed by AD [ 106 ]. Some plants, including MO , have been demonstrated to enhance memory by nootropics activity and protect against the oxidative stress present in AD [ 107 ] Ganguly et al [ 108 ] have an established model for AD involving the infusion of colchicine into the brain of rats and they demonstrated that MO led to the alteration of brain monoamines and electrical patterns. A recent study was conducted to evaluate the effects of an isothiocynate isolated from MO , both in a mouse model of PD and in RAW 264.7 macrophages stimulated with LPS [ 109 ].…”

Section: Effects Of Moringa Oleifera On the Prementioning

confidence: 99%

Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease

2017

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Moringa Oleifera (MO), a plant from the family Moringacea is a major crop in Asia and Africa. MO has been studied for its health properties, attributed to the numerous bioactive components, including vitamins, phenolic acids, flavonoids, isothiocyanates, tannins and saponins, which are present in significant amounts in various components of the plant. Moringa Oleifera leaves are the most widely studied and they have shown to be beneficial in several chronic conditions, including hypercholesterolemia, high blood pressure, diabetes, insulin resistance, non-alcoholic liver disease, cancer and overall inflammation. In this review, we present information on the beneficial results that have been reported on the prevention and alleviation of these chronic conditions in various animal models and in cell studies. The existing limited information on human studies and Moringa Oleifera leaves is also presented. Overall, it has been well documented that Moringa Oleifera leaves are a good strategic for various conditions associated with heart disease, diabetes, cancer and fatty liver.

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“…Administration of leaf extract in different doses for the period of the experiment improved spatial memory and reduced neuronal degeneration to the minimum level in the hippocampal region of the animal disease model, suggesting that an effect was exerted through the decrease in oxidative damage caused by AF64A and enhancement of cholinergic function [ 47 ]. Similarly, M. oleifera leaf extract was also reported to cause up-regulation of Cu/Zn superoxide dismutase (SOD), catalase (CAT) and other enzymes with antioxidant properties, thereby boosting their enzymatic activities, which in turn decreased the activities of pro-oxidant enzymes including but not limited to lipid peroxidase as observed in the cerebral cortex and hippocampal regions of AD rat model [ 48 ].…”

Section: Isothiocyanates (Itcs) and Their Neuroprotective Effectsmentioning

confidence: 99%

Protective Effect of Glucosinolates Hydrolytic Products in Neurodegenerative Diseases (NDDs)

et al. 2018

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Crucifer vegetables, Brassicaceae and other species of the order Brassicales, e.g., Moringaceae that are commonly consumed as spice and food, have been reported to have potential benefits for the treatment and prevention of several health disorders. Though epidemiologically inconclusive, investigations have shown that consumption of those vegetables may result in reducing and preventing the risks associated with neurodegenerative disease development and may also exert other biological protections in humans. The neuroprotective effects of these vegetables have been ascribed to their secondary metabolites, glucosinolates (GLs), and their related hydrolytic products, isothiocyanates (ITCs) that are largely investigated for their various medicinal effects. Extensive pre-clinical studies have revealed more than a few molecular mechanisms of action elucidating multiple biological effects of GLs hydrolytic products. This review summarizes the most significant and up-to-date in vitro and in vivo neuroprotective actions of sulforaphane (SFN), moringin (MG), phenethyl isothiocyanate (PEITC), 6-(methylsulfinyl) hexyl isothiocyanate (6-MSITC) and erucin (ER) in neurodegenerative diseases.

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Effect of Moringa Oleifera in Experimental Model of Alzheimer's Disease : Role of Antioxidants

Cited by 14 publications

References 0 publications

Ameliorative effects of Moringa on cuprizone-induced memory decline in rat model of multiple sclerosis

Ameliorative effects of Moringa on cuprizone-induced memory decline in rat model of multiple sclerosis

Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease

Protective Effect of Glucosinolates Hydrolytic Products in Neurodegenerative Diseases (NDDs)

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