Ameliorative effects of <i>Moringa</i> on cuprizone-induced memory decline in rat model of
						multiple sclerosis

Omotoso, Gabriel Olaiya; Gbadamosi, Ismail Temitayo; Afolabi, Theresa Titilayo; Abdulwahab, A; Akinlolu, Adelaja

doi:10.5115/acb.2018.51.2.119

Cited by 37 publications

(22 citation statements)

References 32 publications

(38 reference statements)

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“…In addition, CPZ diet showed neurotoxic effects evidenced by chromatolysis, abnormal Nissl granules, hyperchromatic nuclei and vacuolated neurons in the prefrontal cortex that is also ameliorated by DAP treatment. Previous studies have demonstrated that CPZ administration resulted in prefrontal cortex and hippocampus damage inducing pyknosis, central chromatolysis and cellular fragmentations [43,44]. The changes in the cellular morphology may be linked to the elevation of oxidative stress mediators such as superoxide anion and nitrite ad that can damage neurons and apoptosis [45,46].…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Repurposing of Dapsone as Neuroprotective Agent on Cuprizone-induced Demyelination via Targeting Nrf2 and NF-kB in C57BL/6 Mice

Dehpour

Khaledi

Noori

et al. 2021

Preprint

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Multiple Sclerosis (MS) is an inflammatory disorder wherein the myelin of nerve cells in central nervous system is damaged. Fatigue, lack of coordination, blurred vision and mental problems are some of the symptoms of MS. In the current study, we assessed the performance of Dapsone (DAP) on improvement of behavioral dysfunction and preservation of myelin in the cuprizone (CPZ) induced demyelination model via targeting Nrf2 and IKB. MS was induced in C57BL/6 mice through diet supplementation of CPZ (0.2%) for 6 weeks and DAP (12.5 mg/kg/day; i.p.) was administered once daily for the last 2 weeks of treatment. Behavioral tests (pole test and rotarod performance test), LFB and H&E staining and Immunohistochemistry (IHC) staining of p-Nrf2 and p-IKB were performed to evaluate locomotor coordination, observe the area of demyelination in corpus callosum respectively. Furthermore, superoxide dismutase (SOD), and nitrite were measured. Based on the results of the weight of mice, it was shown that the weight of the groups receiving CPZ decreased compared to the control group (P < 0.001), while administration of dapsone increased the weight (P < 0.001). Pole test showed that CPZ increased latency time to fall (P <0.01) but the latency to reach the floor in DAP-CPZ group was significantly shorter than the CPZ group (P <0.001). Rotarod performance test showed the effect of CPZ in reducing fall time in CPZ group (P <0.01) however treatment with DAP significantly increased fall time (P < 0.001). In LFB staining increased demyelination was seen in the CPZ group and decreased demyelination was observed in the DAP group. IHC staining results of p-Nrf2 and p-IKB showed that CPZ significantly decreased p-Nrf2 and elevated p-IKB levels compared with the control group (P <0.001), but in DAP -treated groups markedly modified these changes (P < 0.001). CPZ feeding led to increase of brain nitrite levels and reduced SOD activity (P <0.05) but in DAP-treated considerably reversed CPZ-induced changes in nitrite and SOD activity level (P <0.001). These data support the suggestion that the beneficial properties of dapsone on the CPZ-induced demyelination are mediated by targeting Nrf2 and NF-kB pathways.

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Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Repurposing of Dapsone as Neuroprotective Agent on Cuprizone-induced Demyelination via Targeting Nrf2 and NF-kB in C57BL/6 Mice

Dehpour

Khaledi

Noori

et al. 2021

Preprint

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“…In this study, the MWM method was adopted to evaluate the cognitive-enhancing effects of the aqueous and stem bark extracts of L. eriocalyx in scopolamine-induced cognitively impaired mice model. This technique has been broadly utilized to screen drug agents proposed for dementia and symptoms of cognitive impairment [ 42 – 46 ]. The MWM task is useful in assessing spatial learning and memory in laboratory animals and humans.…”

Section: Discussionmentioning

confidence: 99%

Cognitive-Enhancing, Ex Vivo Antilipid Peroxidation and Qualitative Phytochemical Evaluation of the Aqueous and Methanolic Stem Bark Extracts of Lonchocarpus eriocalyx (Harms.)

Moriasi

Ireri

Ngugi

2020

Biochemistry Research International

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Over 50 million persons are living with cognitive deficits worldwide, with over 80% of these individuals living in the developing world. The number of affected persons is projected to go over 152 million by the year 2050. Current drugs used for cognitive impairment are debatably ineffective, costly, inaccessible, and associated with undesirable events that call for the search for alternative and complementary approaches. Plants are arguably affordable, accessible, and efficacious. However, despite the reported healing claims, scientific data validating these claims are lacking. L. eriocalyx is traditionally used for the management of various conditions, including cognitive impairment but has not been scientifically explored. In this study, the Morris Water Maze (MWM) method was used to evaluate in vivo cognitive-enhancing effects of studied extracts of L. eriocalyx. Furthermore, following MWM experiments, brains were dissected and processed, and malondialdehyde profiles were determined. Qualitative phytochemical profiles of the studied plant extracts were also determined. The results showed that mice that were treated with the studied plant extracts took significantly shorter transfer latencies, navigation distances, and significantly longer latencies in the target quadrant (NW) (p<0.05) compared with the negative control mice, indicating cognitive-enhancing activities. Furthermore, cognitively impaired mice that received the studied plant extracts had significantly lower MDA profiles compared with the MDA profile of the negative control group mice (p<0.05). The cognitive-enhancing and MDA profile lowering effects were attributed to the presence of antioxidant phytoconstituents that ought to have modulated the redox state, thereby attenuating brain damage. These extracts can be, therefore, used for the management of cognitive deficits. Further studies leading to isolation and characterization of active molecules for cognitive impairment are recommended. Furthermore, the precise mechanism(s) through which these extracts exert their pharmacologic activity should be established.

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“…Hence, this study further investigated the neurotoxic tendencies of permethrin on the antioxidant status of brain regions using SOD, GPx and CAT as biomarkers. These enzymes are in the frontline of antioxidant defense system [ 42 , 43 ]. Findings showed that permethrin affected the activities of these enzymes in a dose-dependent pattern across the three brain regions, such that the higher the dose of permethrin, the lower the enzyme activities.…”

Section: Discussionmentioning

confidence: 99%

Permethrin exposure affects neurobehavior and cellular characterization in rats' brain

Omotoso

Oloyede

Lawal

et al. 2020

Environ Anal Health Toxicol

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This study investigated the neurotoxic effects of permethrin on the cerebellum, hippocampus and prefrontal cortex of Wistar rats and its effects on some behavioral patterns. Fifteen adult male Wistar rats were grouped into three categories: Group A received 0.1 mL normal saline (control), and Groups B and C received mixed feed with 500 mg/kg and 1,000 mg/kg of 0.6% permethrin, respectively, for 14 days. The animals were assessed for memory, anxiety and exploratory locomotion and thereafter anesthetized and transcardially perfused with normal saline and 4% paraformaldehyde (PFA). Cerebellum, hippocampus and prefrontal cortex were excised from the whole brain and processed for tissue histology, histochemistry and immunohistochemistry. Oxidative status and lipid peroxidation were also assessed using catalase, glutathione peroxidase, superoxide dismutase and malondialdehyde as biomarkers. Results revealed dosedependent decrease in body weights but increase in cerebellar and prefrontal weights, depletion of endogenous antioxidant markers, cognitive deficits, reduced locomotor activities, degenerative changes in the microarchitecture at high doses and presence of chromatolytic cells at both low and high doses of permethrin. Astrocytes were activated while synaptophysin expression was downregulated. Permethrin causes dose-dependent neurotoxicity on the morphology, neurochemistry and oxidative status of different brain regions, and these could affect behavioral performance and other neurologic functions.

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Ameliorative effects of Moringa on cuprizone-induced memory decline in rat model of multiple sclerosis

Cited by 37 publications

References 32 publications

WITHDRAWN: Repurposing of Dapsone as Neuroprotective Agent on Cuprizone-induced Demyelination via Targeting Nrf2 and NF-kB in C57BL/6 Mice

WITHDRAWN: Repurposing of Dapsone as Neuroprotective Agent on Cuprizone-induced Demyelination via Targeting Nrf2 and NF-kB in C57BL/6 Mice

Cognitive-Enhancing, Ex Vivo Antilipid Peroxidation and Qualitative Phytochemical Evaluation of the Aqueous and Methanolic Stem Bark Extracts of Lonchocarpus eriocalyx (Harms.)

Permethrin exposure affects neurobehavior and cellular characterization in rats' brain

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