Effect of Moringa oleifera Bark Extracts on Dexamethasone-induced Insulin Resistance in Rats

Sholapur, Hasanpasha; Patil, B. M.

doi:10.1055/s-0033-1347238

Cited by 14 publications

(6 citation statements)

References 9 publications

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“…Third, the included studies mostly used male rodents and the outcome could be different when more studies include females or both sexes. Fourth, dexa-induced insulin-resistant rodent models were generated by injection simultaneously during dietary modulation with or without MO in two included studies; thus, there is at least a slight possibility that the investigators' technical skill for chemical injection could directly or indirectly have influenced the experimental outcome of blood glucose levels [43,54].…”

Section: Strength and Limitationsmentioning

confidence: 99%

Moringa oleifera Lam. in Diabetes Mellitus: A Systematic Review and Meta-Analysis

et al. 2021

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Plant-derived phytochemicals have been interested in as nutraceuticals for preventing the onset and progress of diabetes mellitus and its serious complications in recent years. Moringa oleifera Lam. is used in vegetables and in herbal medicine for its health-promoting properties against various diseases including diabetes mellitus. This study aimed to examine an effect of Moringa oleifera on diabetic hyperglycemia and dyslipidemia by meta-analyzing the current evidence of diabetic rodent models. Peer-reviewed studies written in English from two databases, PubMed and Embase, were searched to 30 April 2021. Studies reporting blood glucose or lipid levels in diabetic rodents with and without receiving extracts of Moringa oleifera were included. Forty-four studies enrolling 349 diabetic rodents treated with extracts of Moringa oleifera and 350 diabetic controls reported blood glucose levels. The pooled effect size was −3.92 (95% CI: −4.65 to −3.19) with a substantial heterogeneity. This effect was likely to be, at least in part, modified by the type of diabetic models. Moreover, diabetic hypertriglyceridemia and hypercholesterolemia were also significantly improved in diabetic rodent models treated with Moringa oleifera.

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Section: Strength and Limitationsmentioning

confidence: 99%

Moringa oleifera Lam. in Diabetes Mellitus: A Systematic Review and Meta-Analysis

et al. 2021

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“…Similarly, in present research work oral administration of Me.Mo for consecutive 60 days significantly decreased HFD-induced glucose concentration, however, no marked changes were observed in the model-HFD group. The insulin-sensitizing effect of Me.MO may be due to stimulatory action on receptor insulin signaling pathways as attributed in previously published inline studies [39,40].…”

Section: Discussionmentioning

confidence: 79%

“Regulation of Obesity and Fatty Liver by Moringa oleifera: Insights into Inflammatory Pathways”

Ibrahim,

Buabeid,

Arafa

et al. 2024

Preprint

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Obesity and fatty liver are relatively benign states but continued inflammatory stress and its metabolic implications turn them into one of the most devastating diseases of humankind. Generally, obesity and fatty liver precede diabetes mellitus, cardiovascular problems and malignant growths. The present research aimed to explore the efficacy of methanolic extract of Moringa Olifera (Me.MO) for the management of obesity and fatty liver and related inflammatory state that prime the body for devastating effects. A series of in-vitro and in-vivo studies were employed. Data from HPLC analysis confirmed the presence of flavonoids and phenolic acids. Rats were fed on either normal diet (ND) or high fat diet (HFD and streptozocin (STZ) in the presence or absence of Me.Mo (250 mg/kg & 500 mg/kg) or metformin (70 mg/kg). Findings showed that rats received 500 mg/kg Me.MO showed a significant (p > 0.01) decrease in body weights, liver weights, and plasma glucose level. Laboratory data exhibited a significant (p < 0.05) inhibitory effect on Me.MO on pro-inflammatory mediators (IL-1B and TNF) and caused a sharp increase in anti-inflammatory cytokines levels (IL-10, IL-6 and COX-2) in all treatment groups. Histopathological analysis exhibited no structural and functional alteration in the liver and adipose tissues. Altogether, Me.MO ameliorates experimentally induced obesity accompanying fatty liver and inflammatory stress. However, further investigations are still needed to confirm the safety and efficacy of Moringa beta olifera (MO) for clinical application.

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“…The progression of diabetes was significantly reduced in STZ-diabetic rats treated with methanol extract M. oleifera pods for 21 days with treated animals showing a significant reduction in serum glucose and nitric oxide, with concomitant increases in serum insulin and protein levels [130]. It has also been shown that extracts of the bark of the plant prevented dexamethasone-induced insulin resistance in peripheral tissues [131].…”

Section: Moringa Oleiferamentioning

confidence: 99%

Antidiabetic Botanicals and their Potential Benefits in the Management of Diabetes Mellitus

Akinmoladun¹,

Farombi²,

Oguntibeju³

2014

Antioxidant-Antidiabetic Agents and Human Health

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Effect of Moringa oleifera Bark Extracts on Dexamethasone-induced Insulin Resistance in Rats

Abstract: The present study indicates that AE of Moringa oleifera prevents dexamethasone-induced insulin resistance in peripheral tissues.

Cited by 14 publications

References 9 publications

Moringa oleifera Lam. in Diabetes Mellitus: A Systematic Review and Meta-Analysis

Moringa oleifera Lam. in Diabetes Mellitus: A Systematic Review and Meta-Analysis

“Regulation of Obesity and Fatty Liver by Moringa oleifera: Insights into Inflammatory Pathways”

Antidiabetic Botanicals and their Potential Benefits in the Management of Diabetes Mellitus

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