Moringa oleifera Lam. in Diabetes Mellitus: A Systematic Review and Meta-Analysis

Abstract

Plant-derived phytochemicals have been interested in as nutraceuticals for preventing the onset and progress of diabetes mellitus and its serious complications in recent years. Moringa oleifera Lam. is used in vegetables and in herbal medicine for its health-promoting properties against various diseases including diabetes mellitus. This study aimed to examine an effect of Moringa oleifera on diabetic hyperglycemia and dyslipidemia by meta-analyzing the current evidence of diabetic rodent models. Peer-reviewed studies written in English from two databases, PubMed and Embase, were searched to 30 April 2021. Studies reporting blood glucose or lipid levels in diabetic rodents with and without receiving extracts of Moringa oleifera were included. Forty-four studies enrolling 349 diabetic rodents treated with extracts of Moringa oleifera and 350 diabetic controls reported blood glucose levels. The pooled effect size was −3.92 (95% CI: −4.65 to −3.19) with a substantial heterogeneity. This effect was likely to be, at least in part, modified by the type of diabetic models. Moreover, diabetic hypertriglyceridemia and hypercholesterolemia were also significantly improved in diabetic rodent models treated with Moringa oleifera.

A Review on the Antidiabetic Properties of Moringa oleifera Extracts: Focusing on Oxidative Stress and Inflammation as Main Therapeutic Targets

“…These results are consistent with some preclinical findings ( Jaja-Chimedza et al, 2018 ; Mohamed et al, 2019 ), indicating that Moringa oleifera leaf extracts might be useful complications identified during the early development of T2D. Nonetheless, despite accumulative literature, as reviewed elsewhere ( Ba et al, 2020 ; Watanabe et al, 2021 ), indicating that this plant might present with important antidiabetic properties, more needs to be done to confirm these in clinical settings. It remains crucial, to evaluate whether Moringa oleifera leaf extracts can prominent biomarkers of oxidative stress and inflammation, to verify preclinical findings.…”

“…Dixit and co-workers (Dixit et al, 2018) Mohamed et al, 2019), indicating that Moringa oleifera leaf extracts might be useful complications identified during the early development of T2D. Nonetheless, despite accumulative literature, as reviewed elsewhere (Ba et al, 2020;Watanabe et al, 2021), indicating that this plant might present with important antidiabetic properties, more needs to be done to confirm these in…”

Functional cereals' anti‐diabetic property, phenolic composition, and role on glycemic indices in‐vitro

“…Numerous reports have confirmed the role of citrus peels' antidiabetic and antihyperlipidemic properties (Muhtadi et al, 2015), and Ademosun et al (2021) reported the ability of orange peels in unripe plantain noodles in reducing glycemic index in rats. The role of moringa ( Moringa oleifera ) leaves cannot be overemphasized in the management of hypertension, hyperlipidemia (Oyeleye et al, 2019), and chronic hyperglycemia (Watanabe et al, 2021).…”

“Planeterranea”: An attempt to broaden the beneficial effects of the Mediterranean diet worldwide

“…Nevertheless, most of the evidence is provided by in vitro experiments and studies in animal models (91). Besides, a recent meta-analysis of 46 studies in animal models suggested a potential role of Moringa-derived products in the reduction of glucose and lipid levels (92).…”