Effect of Moderate Alcohol Consumption on Hypertriglyceridemia

Abstract

Acute alcohol intake alone is not an important determinant of plasma triglyceride concentration in individuals with HTG. Other factors, such as the contemporaneous consumption of fat and alcohol, known to increase triglyceride concentrations synergistically in non-HTG individuals, may be more important.

Triglycerides and Cardiovascular Disease

“…Steroids 108 Tamoxifen 124 Thiazides 125 Diet* Alcohol excess, especially with a high saturated-fat diet 126,127 Diseases* Autoimmune chylomicronemia (eg, antibodies to LPL, 128 SLE 129 ) Chronic idiopathic urticaria 130 Renal disease 131 GPIHBP1 indicates glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1; LPL, lipoprotein lipase; and SLE, systemic lupus erythematosus.…”

“…Ethanolinduced lipemia may be due to inhibition of LPL-mediated hydrolysis of chylomicrons. 126,451,452 Therefore, in subjects with very high triglyceride levels, complete abstinence is strongly recommended in concert with reduced saturated fat intake to reduce the likelihood of pancreatitis. 105 …”

Evidence-Based Nutrition Principles and Recommendations for the Treatment and Prevention of Diabetes and Related Complications

“…This increase in synthesis is enhanced by a genetic predisposition, high-fat diet, and diabetes (445). Increased lipoprotein synthesis may be more an effect of chronic or excessive alcohol intake, as nondiabetic subjects with fasting hypertriglyceridemia who, in one Technical Review study, consumed the equivalent of two alcoholic beverages did not demonstrate an acute increase in triglycerides (417). This suggests that even people with hypertriglyceridemia may occasionally use alcohol in moderation.…”

EmTriglyceride-Induced Pancreatitis: Diagnostic and Therapeutic Approach

“…Patients with this disorder often have low LDL levels as well. Such patients have been found to demonstrate particularly labile triglyceride levels with sharp increases when consuming alcohol and sharp decreases when eventually ceasing alcohol use [19]. These triglyceride fluctuations may delay the consideration of the lipid disorder as a possible factor contributing to acute pancreatitis.…”