Effect of MITF-M and MITF-A Overexpression on the Dendrtic Formation in Melanocytes

Jo, In Sook; Sohn, Kyung Cheol; Kim, Chang Deok; Lee, Young Ho

doi:10.11637/kjpa.2016.29.1.27

Cited by 2 publications

(1 citation statement)

References 25 publications

(2 reference statements)

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“…Additionally, IDH3B has been shown to promote the transition between the G1 and S phase stimulating cell proliferation, and its over-expression has been related to poor survival [ 113 ]. Moreover, MITF is known to play an essential role during the differentiation of the retinal pigment epithelium and can regulate melanogenesis [ 114 , 115 ].…”

Section: Discussionmentioning

confidence: 99%

The regulatory landscape of retinoblastoma: a pathway analysis perspective

et al. 2022

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Retinoblastoma (Rb) is a rare intraocular tumour in early childhood, with an approximate incidence of 1 in 18 000 live births. Experimental studies for Rb are complex due to the challenges associated with obtaining a normal retina to contrast with diseased tissue. In this work, we reanalyse a dataset that contains normal retina samples. We identified the individual genes whose expression is different in Rb in contrast with normal tissue, determined the pathways whose global expression pattern is more distant from the global expression observed in normal tissue, and finally, we identified which transcription factors regulate the highest number of differentially expressed genes (DEGs) and proposed as transcriptional master regulators (TMRs). The enrichment of DEGs in the phototransduction and retrograde endocannabinoid signalling pathways could be associated with abnormal behaviour of the processes leading to cellular differentiation and cellular proliferation. On the other hand, the TMRs nuclear receptor subfamily 5 group A member 2 and hepatocyte nuclear factor 4 gamma are involved in hepatocyte differentiation. Therefore, the enrichment of aberrant expression in these transcription factors could suggest an abnormal retina development that could be involved in Rb origin and progression.

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Section: Discussionmentioning

confidence: 99%

The regulatory landscape of retinoblastoma: a pathway analysis perspective

et al. 2022

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A Study on Correlation of Melanin & Pigmentation Disorder and Viscera and Bowels(臟腑)

Jung¹,

Ko²,

Yoon³

2016

The Journal of Korean Medicine Ophthalmology and Otolaryngology

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Objectives : The purpose of this research is to understand melanin with both Korean and Western medicine. Methods : We investigated the comprehension of melanin in both western and Korean medicine through literature review and studied relationships between melanin and five viscera(五臟), especially liver(肝), spleen(脾), kidney(腎). We Also studied representative pigmentary disorders(melasma, vitiligo) in western and Korean medicine to figure out how to understand pigmentary disorders in oriental medicine.Results : The results are as follows.

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Effect of MITF-M and MITF-A Overexpression on the Dendrtic Formation in Melanocytes

Cited by 2 publications

References 25 publications

The regulatory landscape of retinoblastoma: a pathway analysis perspective

The regulatory landscape of retinoblastoma: a pathway analysis perspective

A Study on Correlation of Melanin & Pigmentation Disorder and Viscera and Bowels(臟腑)

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