Effect of microwave radiation on polymer microcapsules containing inorganic nanoparticles

Gorin, Dmitry A.; Shchukin, Dmitry G.; Михайлов, А. И.; Köhler, Karen; Сергеев, С. А.; Портнов, С. А.; Taranov, I. V.; Kislov, V. V.; Sukhorukov, Gleb B.

doi:10.1134/s1063785006010238

Cited by 45 publications

(30 citation statements)

References 10 publications

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“…[1] This technique is applied to form both planar layers and multilayer 3D microshells (i.e., microcapsules). [2][3][4][5][6][7][8][9][10][11][12] The potential application of microcapsules for targeted delivery requires accomplishing two tasks, which are the encapsulation of different substances into the inner volume of the microcapsules and the modification of the capsule shell to enable targeted delivery and controlled release of encapsulated material. Nowadays, the main problem consists in the controlled release of the microcapsule content near the predetermined areas.…”

Section: Introductionmentioning

confidence: 99%

“…To achieve this goal, the permeability of the microcapsule shells can be modified to facilitate the release of encapsulated species by varying the temperature or medium acidity, by action of different external influences such as laser and microwave radiation, alternating magnetic field, etc. [6][7][8][9][13][14][15][16] However, these methods possess several limitations especially in relation to biological and medical research. For instance, heating and pH change affect a large number of microcapsules but application of this treatment in living organisms is highly difficult.…”

Section: Introductionmentioning

confidence: 99%

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Nanocomposite Microcontainers with High Ultrasound Sensitivity

Колесникова

Gorin

Fernandes

et al. 2010

Adv Funct Materials

105

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A water suspension of nanocomposite microcapsules with embedded ZnO nanoparticles in the capsule shell is reported. The microcapsule morphology is characterized by confocal microscopy, TEM, SEM, and AFM before and after ultrasound treatment. A remarkably high capsule sensitivity to ultrasound is evidenced, and it is observed to grow with increasing number of ZnO nanoparticle layers in the nanocomposite shell. This effect is correlated with the mechanical properties of microcapsules measured with AFM.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanocomposite Microcontainers with High Ultrasound Sensitivity

Колесникова

Gorin

Fernandes

et al. 2010

Adv Funct Materials

105

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“…The permeability of microcapsule shells can be modified by various methods to facilitate the release of encapsulated drugs, for example, by varying the temperature [28] or acidity of a medium [20,21], by microwave [29] and laser radiation [14], and by application of an alternating magnetic field [15]. The effect of laser radiation is based on the heating of metal particles incorporated in the shell of microcapsules, which leads to a change in the permeability or even complete destruction of the shell and the resulting release of encapsulated drugs.…”

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confidence: 99%

Atomic force microscopy characterization of ultrasound-sensitive nanocomposite microcapsules

et al. 2008

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In recent years, considerable effort has been devoted to the development and investigation of systems for controlled delivery of drugs. Targeted delivery of drugs significantly increases their efficacy and allows the total drug concentration in the organism to be considerably decreased. In order to solve this task, special containers/carriers have been designed possessing preset and controlled physicochemical and mechanical properties. The function of such containers can be performed, for example, by polymeric micelles [1][2][3][4], liposomes [5], emulsions [4, 6, 7], and colloidal particles. This class also includes polyelectrolyte (PE) microcapsules obtained by the method of polyion assembly, which consists in sequential adsorption of oppositely charged PE molecules on the surface of colloidal particles (templates), followed by the dissolution and removal of the initial core [8,9]. Using this approach, it is possible to obtain capsules with a broad range of preset dimensions (from 50 nm to 50 µ m) and a broad spectrum of shell materials. Indeed, the shells of microcapsules can be made of almost any synthetic and natural PEs [8,[10][11][12][13], lipid bilayers, inorganic nanoparticles (e.g., of silver, gold, or iron(III) oxide) [14][15][16], and polyvalent metal ions. The core (template) material can be selected from colloidal particles of various kinds with diameters ranging from tens of nanometers to several tens of microns [8,10,[17][18][19]. The capsule walls can also be controlled with respect to thickness, functional role, and permeability to any low-and high-molecular-mass compounds [20][21][22].The unique properties of PE microcapsules make it possible to use them in various fields of science and technology, such as biotechnology, cosmetics, the food industry, and medicine. The main advantage to such capsules in medical diagnostics is possibility of filling them with various drugs [23] and controlling their properties (e.g., elasticity and deformability) by varying the shell composition, template material, solvent [24], and the nature and number of PE layers. However, in order to ensure the desired result, a container must release the encapsulated drug in the immediate vicinity of damaged cells. For this purpose, inorganic magnetic nanoparticles of Fe 3 O 4 (magnetite) possessing pronounced magnetic properties can be introduced in the shell composition at the synthesis stage, which makes it possible to control the motion of capsules under an applied external magnetic field. Magnetite nanoparticles also possess certain advantages from a pharmaceutical standpoint: (i) the surface of these particles can be readily modified with compounds ensuring the biocompatibility and selective adsorption of microcapsules on damaged cells; (ii) the magnetic parameters of nanoparticles make their local concentration possible with the aid of magnetic fields [25][26][27]. The magnetic-fieldcontrolled delivery and localization of magnetic nanoparticles with a preset magnetic transition temperature Atomic Force Microscopy Ch...

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“…17 However, many applications also require remote control over the permeability of the microcapsule shell. This can be done by light or laser irradiation, [18][19][20][21][22][23] alternating magnetic field, 24 microwave radiation 25 or ultrasound. [26][27][28] Considerable progress was achieved in the use of laser irradiation for microcapsule opening.…”

Section: Introductionmentioning

confidence: 99%

Magnetic/gold nanoparticle functionalized biocompatible microcapsules with sensitivity to laser irradiation

Gorin

Портнов

Inozemtseva

et al. 2008

Phys. Chem. Chem. Phys.

124

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Nanocomposite microcapsules with both gold and magnetite nanoparticles in the shell were prepared in a layer-by-layer procedure using biocompatible polyelectrolytes and nanoparticles. The process of a nanocomposite multilayer formation was investigated using a quartz crystal microbalance (QCM). In addition, nanocomposite microcapsules were characterized by atomic force microscopy (AFM), transmission electron microscopy (TEM) and energy-dispersive X-ray spectroscopy (EDX). It is found that the amount of adsorbed nanoparticles is similar for nanoparticles of various sizes, while the concentration of gold nanoparticles in the shell is higher for smaller nanoparticles. Adsorption of gold nanoparticles is found to be more effective than adsorption of magnetic nanoparticles. Multifunctionality of microcapsules is manifested by dual: magnetic and optical responses. Iron oxide nanoparticles embedded in the microcapsule shell allowed for control over capsules positioning by external magnetic fields. Furthermore, the nanocomposite microcapsules could be opened by laser irradiation; these results are of interest for medical and biological applications.

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Effect of microwave radiation on polymer microcapsules containing inorganic nanoparticles

Cited by 45 publications

References 10 publications

Nanocomposite Microcontainers with High Ultrasound Sensitivity

Nanocomposite Microcontainers with High Ultrasound Sensitivity

Atomic force microscopy characterization of ultrasound-sensitive nanocomposite microcapsules

Magnetic/gold nanoparticle functionalized biocompatible microcapsules with sensitivity to laser irradiation

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