Effect of microinjection of histamine into the dorsal hippocampus on the orofacial formalin-induced pain in rats

Role of the thalamic submedius nucleus histamine H1 and H2 and opioid receptors in modulation of formalin-induced orofacial pain in rats

“…Mepyramine alone did not modify the evoked firing of thalamic neurons, whereas pretreatment with it prevented the suppressive effect of histamine suggesting the involvement of histamine H 1 receptors in chronic pain modulation (Braga et al 1996). In addition, prior microinjection of histamine H 1 receptor antagonists such as mepyramine and chlorpheniramine into the various brain areas including the hippocampus, dentate gyrus, and anterior cingulated cortex prevented the antinociceptive effects of histamine microinjected into the same sites (Hamzeh-Gooshchi et al 2015;Khalilzadeh et al 2010;Erfanparast et al 2010). Therefore, it seems that at the level of the Sm, histamine H 1 receptor may have a role in modulation of orofacial region pain.…”

“…In local peripheral and spinal pathways of pain, blockade of histamine H 1 receptors attenuates histamine-induced pain-like behaviors (Sakurada et al 2003;Parada et al 2001;Hong and Abbott 1994). At the supraspinal level, histamine H 1 receptor antagonists prevent histamine-induced antinociception (HamzehGooshchi et al 2015;Tamaddonfard et al 2011;Erfanparast et al 2010;Thoburn et al 1994). These different roles of histamine H 1 receptors in pain modulation can describe different responses after activation of them.…”

“…In addition to pain-enhancing property in the skin and spinal cord (Kajihara et al 2010), histamine, through its H 1 , H 2 , and H 3 receptors, produces analgesic effects when microinjected into the cerebral ventricles or brain regions including periaquaeductal gray (PAG), dorsal hippocampus (CA1), dentate gyrus (DG), locus coeruleus (LC), primary somatosensory cortex (PSC), and anterior cingulated cortex (ACC) (Lamberti et al 1996;Tamaddonfard and Rahimi 2004;Erfanparast et al 2010;Khalilzadeh et al 2010;Hough and Rice 2011;Wei et al 2014;Tamaddonfard and Hamzeh-Gooshchi 2014;HamzehGooshchi et al 2015). It is well known that opioid system, through mu, delta, and kappa receptors, mediates local peripheral, spinal, and supraspinal mechanisms of pain and analgesia (Kanjhan 1995;Stein and Zollner 2009;Bodnar 2014).…”

Effects of microinjection of histamine into the anterior cingulate cortex on pain-related behaviors induced by formalin in rats

“…At the supraspinal level, the involvement of histamine H 1 , H 2 and H 3 receptors have been reported in the antinociceptive effects induced by microinjection of histamine into the brain regions such as periaqueductal gray (PAG), raphe nucleus (RN), locus coeruleus (LC), dorsal hippocampus (DH), dentate gyrus (DG) and primary somatosensory cortex (PSC) [4][5][6][7][8]. By using of naloxone (an opioid receptors antagonist), the involvement of opioid receptors in centrally administered histamine-induced antinociception have been reported [8,9].…”

Evaluating the Anti-nociceptive and Anti-inflammatory Effects of Ketotifen and Fexofenadine in Rats

“…34 Later on, an interaction between pain-relieving drugs and the brain histaminergic system was reported and multiple analgesic mechanisms suggested for antihistamines such as improgan and even cimetidine. 35 In addition, the role of histamine in different types of pain include central, 36 peripheral, 37 acute 38 chronic 39 or organ related pains such as muscle pain 40 was declared and the number of studies about antihistaminic agents administration as analgesic drugs have been augmented and hyper algesic role of H1 receptors have been proved strongly. 3,20 In this study ketotifen was capable of inhibiting both acute and chronic phase in formalin induced pain model.…”