Effects of microinjection of histamine into the anterior cingulate cortex on pain-related behaviors induced by formalin in rats

Abstract

The results of the present study showed pain suppressing effects for histamine. Histamine H2 and H3, and to a lesser extent, H1 receptors might be involved in histamine-induced antinociception. Opioid receptors might be involved in suppressive effects of histamine and thioperamide.

Role of the thalamic submedius nucleus histamine H1 and H2 and opioid receptors in modulation of formalin-induced orofacial pain in rats

“…Mepyramine alone did not modify the evoked firing of thalamic neurons, whereas pretreatment with it prevented the suppressive effect of histamine suggesting the involvement of histamine H 1 receptors in chronic pain modulation (Braga et al 1996). In addition, prior microinjection of histamine H 1 receptor antagonists such as mepyramine and chlorpheniramine into the various brain areas including the hippocampus, dentate gyrus, and anterior cingulated cortex prevented the antinociceptive effects of histamine microinjected into the same sites (Hamzeh-Gooshchi et al 2015;Khalilzadeh et al 2010;Erfanparast et al 2010). Therefore, it seems that at the level of the Sm, histamine H 1 receptor may have a role in modulation of orofacial region pain.…”

“…Moreover, intracerebroventricular injection of zolantidine and tiotidine (an H 2 antagonist) inhibited morphine-induced analgesia in hot-plate and tailflick nociception (Hough and Nalwalk 1992). It also has been found an interaction between opioid receptor and histamine at the cerebral cortex areas in modulation of formalin-induced pain in rats (Hamzeh-Gooshchi et al 2015;Tamaddonfard and Hamzeh-Gooshchi 2014). Therefore, the results of the present study showed interactions between histamine H 1 and H 2 receptors with opioid receptor at the level of the Sm in modulation of orofacial pain.…”

“…Locomotor activity was performed in an open-field test as described previously (Hamzeh-Gooshchi et al 2015). The apparatus consisted of a wooden box measuring 120×120× 50 cm.…”

“…It is well known that opioid system, through mu, delta, and kappa receptors, mediates local peripheral, spinal, and supraspinal mechanisms of pain and analgesia (Kanjhan 1995;Stein and Zollner 2009;Bodnar 2014). Using naloxone, some researchers have suggested possible interactions between histamine and opioid systems in supraspinal modulation of pain and analgesia (Tamaddonfard et al 2011;Tamaddonfard and Hamzeh-Gooshchi 2014;Hamzeh-Gooshchi et al 2015).…”

Inhibition of the cAMP/PKA/CREB Pathway Contributes to the Analgesic Effects of Electroacupuncture in the Anterior Cingulate Cortex in a Rat Pain Memory Model

“…The activation of the cAMP/PKA/CREB signaling pathway can improve the recognition function [16] and exert an antidepressive action [17] through the enhancement of structural synaptic plasticity in the hippocampus [15, 18]. The ACC is an area that encodes pain averseness, thus contributing to pain modulation [19, 20]. As we discovered in a previous study, the phosphorylation of CREB (p-CREB) results in a profound increase in pain memory in the ACC [21].…”