Effect of microflora and lactose on the absorption of calcium, phosphorus and magnesium in the hindgut of the rat

Andrieux, C.P.; Sacquet, E

doi:10.1051/rnd:19830210

Cited by 29 publications

(8 citation statements)

References 18 publications

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“…These substances seemed to have no effect in conventional (CV) rats (Andrieux, Sacquet and Gu6guen, 1980). These results evidenced probable destruction of MRP by the microflora, as already reported by Nesheim and Carpenter (1967), Valle-Riestra and Barnes (1970), Sgarbieri et al (1972), Adrian and Frangne (1973), Tanaka, Chichester (1975), Johnson, Baker andPerkins (1979 The method used to estimate mineral absorption has already been described (Andrieux and Sacquet, 1983 (Reynold, 1965) and that Ca stabilizes some of their constituents (Petit, 1959). However, Mg and Ca absorption was not significantly lower in the cecum and colon of GF rats.…”

supporting

confidence: 60%

Effects of Maillard's reaction products on apparent mineral absorption in different parts of the digestive tract. The role of microflora

Andrieux¹,

Sacquet²

1984

Reprod. Nutr. Dévelop.

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Summary. 1.5 and 3 % of Maillard's reaction products (MRP), prepared by heating glycine and glucose, were incorporated into a semi-synthetic diet. The diet was sterilized by irradiation. MRP caused a change in apparent absorption of calcium and magnesium in germfree (GF) and conventional (CV) rats. The absorption of these minerals was reduced in the small intestine of CV and GF, perhaps due to the action of MRP on enterocyte metabolism. This effect was compensated for only in CV rats by increased absorption of these minerals in the cecum and the colon. The presence of microflora and the increase in cecal volume in CV rats suggested that MRP fermentation increased mineral absorption in the cecum and colon. However, although total apparent absorption of magnesium and phosphorus was higher in CV rats ingesting MRP, the urinary excretion of these minerals was also higher and their retention was not better. The effect of MRP in GF rats was not compensated for in the cecum, and mineral retention was significantly reduced in GF rats ingesting MRP. Introduction.

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supporting

confidence: 60%

Effects of Maillard's reaction products on apparent mineral absorption in different parts of the digestive tract. The role of microflora

Andrieux¹,

Sacquet²

1984

Reprod. Nutr. Dévelop.

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“…On the other hand, there is evidence against the hypothesis that lactose stimulates calcium absorption in the germ-free rat (22,23) and maltitol also stimulates calcium absorption in everted ileal segments (9). These findings indicate that the low pH in the intestine is not only related to calcium absorption.…”

Section: Discussionmentioning

confidence: 42%

Effect of Galactooligosaccharides on Calcium Absorption in Rats.

Chonan

Watanuki

1995

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe effect of transgalactosylated oligosaccharides (TOS), which are oligosaccharides that are unhydrolyzed in the small intestine and are fermented by the intestinal bacteria, on calcium absorption was examined in male Wistar rats for 10 days. The apparent calcium absorp tion ratios and the apparent retention ratios were significantly higher in the rats fed TOS-containing diets (5 or 10 g/100g of diet). In the second experiment, the cecum was ligated in situ and calcium absorption from the cecum was observed after injecting TOS into the cecal lumen. Four hours after the injection, the calcium concentration in the cecal vein of the rats given TOS was significantly higher than that of the control. The calcium content in the liquid phase of the cecal lumen and the liquid phase weight were also increased by the injection of TOS into the cecum. Although the extent of calcium absorption from the cecum of rats fed TOS is due to overall calcium absorption is not known, under the experimental condi tions used in the present study the stimulatory effect of TOS on calcium absorption may be partly associated with increased solubility of calcium and the fluid content in the intestinal lumen.

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“…The absorbed VFA are metabolized predominantly in the liver and thus contribute to the energy needs of the animals. It was shown that in germfree rats, where no microbes are present in the cecum to cause fermentation, a diet which includes 10% lactose leads to uptake of calcium from the large intestine [38]. The presence of lactose apparently keeps the calcium in a form which is liable to be absorbed.…”

Section: Carbohydrate Metabolism In the Cecum And Colonmentioning

confidence: 99%

Intestinal Absorption of Carbohydrates and Calcium: A Review

Vogel¹

1989

Starch Stärke

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A review is given of recent publications on the absorption of carbohydrates especially in relation to calcium. Starch and sucrose are hydrolyzed in mammals by enzymes attached to the wall of the jejunum to glucose and fructose. These are rapidly absorbed via carrier mediated mechanisms in adjoining epithelial cells. Feeding relatively high levels of lactose, sugar alcohols or modified starches to rodents leads to enhanced calcium absorption in the ileum. This results in increased urinary calcium, which may lead to lesions of the kidneys and adrenals in rats or to the formation of bladder stones in mice. If not hydrolyzed to absorbable moieties in the small intestine, carbohydrates pass to the cecum where they are fermented by microbial flora. This fermentation leads to cecal enlargement, diarrhoea and a decrease in urinary pH. All these effects, mainly caused by substantially overfeeding the rodents with these carbohydrates, are of no significance to humans consuming a balanced diet. lntestinale Absorption von Kohlenhydraten und Calcium: Eine Ubersicht. Es wird eine Ubersicht gegeben iiber neuere Veroffentlichungen iiber die Absorption von Kohlenhydraten, insbesondere in bezug auf Calcium. Starke und Saccharose werden von Saugetieren zu Glucose und Fructose hydrolysiert durch Enzyme, die an der Wand des Jejunums fixiert sind. Glucose und Fructose werden mittels Ubertragungsmechanismen in benachbarte Zellen des Epithelgewebes rasch absorbiert. Die Fiitterung von Nagetieren mit verhaltnis-mal3ig hohen Prozentsatzen an Lactose, Zuckeralkoholen oder modifizierten Starken fiihrt zu erhohter Calciumabsorption im Ileum. Diese resultiert in einer Zunahme von Calcium im Harn, welche zu Schadigungen in den Nieren und den Nebennieren bei Ratten und zu Blasensteinen bei Mausen fiihren kann. Wenn die Kohlenhydrate nicht im Diinndarm zu absorbierbaren Bruchstiicken hydrolysiert werden, gehen sie in den Blinddarm iiber, wo sie von Mikroben fermentiert werden. Diese Fermentation fiihrt zur VergroRerung des Blinddarms, Durchfall und Erniedrigung des pH-Wertes im Harn. Alle diese Auswirkungen, hauptsachlich verursacht durch betrachtliche Uberfutterung der Nagetiere mit Kohlenhydraten, sind ohne Bedeutung fur Menschen, die eine ausgeglichene Diat einhalten. starchhtarke 41 (1989) Nr. 2, S. 42-48 8 VCH Verlagsgesellschaft mbH, D-

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Effect of microflora and lactose on the absorption of calcium, phosphorus and magnesium in the hindgut of the rat

Cited by 29 publications

References 18 publications

Effects of Maillard's reaction products on apparent mineral absorption in different parts of the digestive tract. The role of microflora

Effects of Maillard's reaction products on apparent mineral absorption in different parts of the digestive tract. The role of microflora

Effect of Galactooligosaccharides on Calcium Absorption in Rats.

Intestinal Absorption of Carbohydrates and Calcium: A Review

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