Effect of Methylimidazole-Induced Hypothyroidism in a Model of Low Retinal Neovascular Incidence

Berkowitz, Bruce A.; Luan, Hongmei; Roberts, Robin

doi:10.1167/iovs.03-0914

Cited by 13 publications

(7 citation statements)

References 16 publications

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“…Lack of IGF-1 in knockout mice prevented normal retinal vascular growth [35]. In our animal studies, methylimidazole-induced hypothyroidism in both control and a model of low retinal NV incidence newborn rats confirmed that thyroid function is linked with normal retinal vascular density and that if some risk of NV already exists, hypothyroidism can have a positive synergistic effect on the appearance of retinal NV [36].…”

Section: Contribution Of Other Factors In Ropsupporting

confidence: 67%

Evidence for a critical role of panretinal pathophysiology in experimental ROP

Berkowitz

Roberts

2009

Doc Ophthalmol

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In this review, we summarize our in vivo studies of retinal pathophysiology in experimental models of retinopathy of prematurity, which were largely focused on the temporal and spatial links between retinal neovascularization (NV), vascular oxygenation, and intraretinal ion regulation. These studies were made possible through the use of magnetic resonance methods. Prior to the phenotype change from normal vessel development to NV, we found little support for a pathogenic role of focal retinal hypoxia at the border of vascular and avascular retina. However, key links were found between retinal NV and functional panretinal defects in both oxygenation to a provocation and intraretinal ion regulation. Through a treatment which reduced NV incidence but not panretinal pathophysiology, proliferative disease was found to last longer than that in the untreated group. These considerations provide compelling evidence that clinical attention directed toward reducing retinal NV should include approaches that reduce functional panretinal pathophysiology.

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Section: Contribution Of Other Factors In Ropsupporting

confidence: 67%

Evidence for a critical role of panretinal pathophysiology in experimental ROP

Berkowitz

Roberts

2009

Doc Ophthalmol

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“…Two animal studies demonstrated a higher frequency of premature retinopathy in neonatal rats with hypothyroidism (15,16). This finding was confirmed by a study in human neonates (17).…”

Section: Introductionmentioning

confidence: 60%

High Serum Thyrotropin Levels Are Associated with Retinal Arteriolar Narrowing in the General Population

Ittermann

Dörr

Völzke

et al. 2014

Thyroid

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“…It has been reported that methimazole-induced hypothyroidism neonatal rats were associated with preretinal neovascularization and reduced retinal vascular areas (Mookadam et al 2004). Similarly, Berkowitz et al (2004) reported exacerbation of oxygen-induced retinopathy in neonatal rats exposed to methylimidazole. These considerations raised the possibility that hypothyroidism may be involved in the formation of retinal neo vasculari zation.…”

Section: Discussionmentioning

confidence: 89%

Association between Subclinical Hypothyroidism and Proliferative Diabetic Retinopathy in Type 2 Diabetic Patients: A Case-Control Study

Yang

Zhang

et al. 2010

Tohoku J. Exp. Med.

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Subclinical hypothyroidism (SCH) is defined as an asymptomatic state characterized by normal serum levels of free thyroxine and elevated serum concentrations of thyrotropin (> 4.0 μ U/ml). The association between SCH and type 2 diabetes has been well established. Proliferative diabetic retinopathy (PDR) that is characterized by neovascularization is a leading cause of visual loss in adults worldwide. However, whether SCH is related to PDR has not been studied. This study thus aimed to evaluate the relationship between SCH and PDR in type 2 diabetes. A total of 371 type 2 diabetic subjects were enrolled: 187 subjects with PDR and 184 subjects without diabetic retinopathy (with HbA1c above 6.5% and at least 10 years of diabetes duration). Subjects with PDR had higher blood pressure, higher serum levels of total cholesterol, low-density lipoprotein cholesterol and thyrotropin, and higher urinary albumin excretion rate. Of the 371 diabetics, 83 subjects (22.4%) were diagnosed as SCH (male 12.1% and female 29.9%). The prevalence of SCH in the PDR group (51/187, 27.3%) was higher than that in the subjects without diabetic retinopathy (32/184, 17.4%). Logistic regression analysis showed that after adjusting for compounding variables, SCH was independently related with PDR ( p = 0.032, adjusted OR = 2.485). These results indicate that type 2 diabetic patients with PDR are at an increased risk of SCH. A routine screening for thyroid function may thus be considered advisable in PDR subjects. This may be helpful in investigating new strategies preventing or treating PDR in clinical practice.

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Effect of Methylimidazole-Induced Hypothyroidism in a Model of Low Retinal Neovascular Incidence

Abstract: These data are consistent with the notions that thyroid function contributes to normal retinal vascular density and that hypothyroidism can play a permissive role in the development of retinal NV.

Cited by 13 publications

References 16 publications

Evidence for a critical role of panretinal pathophysiology in experimental ROP

Evidence for a critical role of panretinal pathophysiology in experimental ROP

High Serum Thyrotropin Levels Are Associated with Retinal Arteriolar Narrowing in the General Population

Association between Subclinical Hypothyroidism and Proliferative Diabetic Retinopathy in Type 2 Diabetic Patients: A Case-Control Study

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