The purpose of this study was to assess the effectiveness of activated nano-curcumin as a cancertargeted therapy. Six groups of albino mice with cancer implants were used for this study. Sono-(ultrasound) and photo-(blue laser) were used as energy sources. The outcomes showed that nanocurcumin is an effective photo-sono sensitizer for the treatment of cancer. Upon activation with blue laser and/or ultrasound, nano-curcumin plays a crucial part in inhibiting tumor development and promoting cancer cell death. Our ndings showed that activated nano-curcumin might be used as a natural nanosensitizer for cancer targeted sono-photobiomodulation therapy (SPBMT). Highlights 1. New trend of cancer treatment: sono-photo-biomodulation therapy (SPBMT) in combination with nano-curcumin as a sono-photo-sensitizer.
2.A phytochemical nanomaterial with great potential as effective drug delivery targeting system for SPBMT.3. Nontoxic, safe and locally activated cancer treatment modality. 4. Selective cancer killing.