The purpose of this study was to assess the effectiveness of activated nano-curcumin as a cancertargeted therapy. Six groups of albino mice with cancer implants were used for this study. Sono-(ultrasound) and photo-(blue laser) were used as energy sources. The outcomes showed that nanocurcumin is an effective photo-sono sensitizer for the treatment of cancer. Upon activation with blue laser and/or ultrasound, nano-curcumin plays a crucial part in inhibiting tumor development and promoting cancer cell death. Our ndings showed that activated nano-curcumin might be used as a natural nanosensitizer for cancer targeted sono-photobiomodulation therapy (SPBMT). Highlights 1. New trend of cancer treatment: sono-photo-biomodulation therapy (SPBMT) in combination with nano-curcumin as a sono-photo-sensitizer. 2.A phytochemical nanomaterial with great potential as effective drug delivery targeting system for SPBMT.3. Nontoxic, safe and locally activated cancer treatment modality. 4. Selective cancer killing.

The purpose of this study was to assess the effectiveness of activated nano-curcumin as a cancer-targeted therapy. Six groups of albino mice with cancer implants were used for this study. Sono- (ultrasound) and photo- (blue laser) were used as energy sources. The outcomes showed that nano-curcumin is an effective photo-sono sensitizer for the treatment of cancer. Upon activation with blue laser and/or ultrasound, nano-curcumin plays a crucial part in inhibiting tumor development and promoting cancer cell death. Our findings showed that activated nano-curcumin might be used as a natural nanosensitizer for cancer targeted sono-photobiomodulation therapy (SPBMT).