Effect of Methoxyindole Administration on Plasma Cation Levels in the Rat

Morton, Dougal J.

doi:10.1111/j.1600-079x.1989.tb00411.x

Cited by 5 publications

(2 citation statements)

References 14 publications

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“…Furthermore, we found that CC14 administration did not statistica]ly affect serum magnesium levels, whereas melatonin significantly decreased these levels. Melatonin has been reported to decrease magnesium levels with negative feedback mechanism in previous studies (20), thus supporting the effect of melatonin on serum magnesium level.…”

Section: Discussionsupporting

confidence: 54%

Effects of melatonin on carbon tetrachloride-induced changes in rat serum

Ögetürk

Kuş

Kavakli

et al. 2004

J. Physiol. Biochem.

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Carbon tetrachloride (CCl4) is a volatile organic chemical, which causes tissue damage, especially to the liver and kidney. In experimental animals it has been shown to be carcinogenic. This study was designed to evaluate the effects of exogenous melatonin administration on the CCl4-induced changes of some biochemical parameters in rat blood. Twenty-four male Wistar rats were randomly divided into three equal groups: Control, CCl4 and CCl4 plus melatonin (CCl4+MEL). Rats in CCl4 group were injected subcutaneously with CCl4 0.5 ml/kg in olive oil while rats in CCl4+MEL group were injected with CCl4 (0.5 ml/kg) plus melatonin (25 mg/kg in 10% ethanol) every other day for one month. Control rats were treated with olive oil. Serum urea, creatinine, total protein, albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total and conjugated bilirubin, alkaline phosphatase (ALP), gamma-glutamyl transferase (gamma-GT), total iron, and magnesium levels were determined. Serum AST, ALT, total and conjugated bilirubin, ALP, gamma-GT, and total iron levels were significantly higher in CCl4-treated rats than in the controls, while urea, total protein, and albumin levels were significantly lower. Melatonin treatment did not cause a significantly change in serum urea, total protein, and albumin levels. However, the elevations in AST, ALT, total and conjugated bilirubin, ALP, gamma-GT, and total iron levels induced by CCl4 injections were significantly reduced by melatonin. On the other hand, melatonin administration significantly decreased serum magnesium levels. These results indicate that melatonin could be a protective agent against the CCl4 toxicity in rats, most likely through its antioxidant and free radical scavenger effects.

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Section: Discussionsupporting

confidence: 54%

Effects of melatonin on carbon tetrachloride-induced changes in rat serum

Ögetürk

Kuş

Kavakli

et al. 2004

J. Physiol. Biochem.

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“…However, it has been reported that plasma Zn concentrations are lowest at night while the rat is most active [27]. Morton has shown that plasma Zn levels decreased after a MEL administration in the morning [28]. In the present study, nighttime serum Zn levels increased in the MEL-treated group compared to daytime.…”

Section: Discussionmentioning

confidence: 41%

Effect of melatonin treatment on serum and tissue zinc levels in rats

Öztürk

Coşkun

Erbaş

et al. 2002

J Trace Elements Exper Med

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Melatonin (MEL) is the main neuro-hormone of the pineal gland. The main physiological function of MEL is to modulate variations of the light-dark cycle and seasonal periodicity on various physiological functions. Zinc (Zn) is required as a catalytic component for more than 200 enzymes and is a structural constituent of many proteins, hormones, neuropeptides, and receptors. In addition, tissue Zn levels have been found to be altered after pinealectomy in rats. Recent findings have shown that MEL can modulate Zn turnover. In the present study, we investigated the effect of MEL treatment on the tissue and serum Zn levels. Male SpraqueÀDawley rats (n = 24) were used. Rats received seven daily subcutaneous injections of MEL (10 mg/kg). After 7 days, rats were decapitated at 10:00 a.m. and 02:00 a.m., which were the periods of lowest and highest serum MEL levels, respectively. Blood and tissue samples were collected, and Zn levels were measured by atomic absorption spectrophotometry. In conclusion, MEL increased Zn levels in the salivary glands and small intestine. Daytime liver Zn levels and nighttime serum Zn levels increased in MELtreated group. There was no significant difference in brain after MEL treatment. Nighttime serum MEL levels were higher than daytime in both control and MELtreated group. In addition, MEL levels in MEL-treated groups were significantly higher than those of control groups. It is clear that there is a tight relationship between Zn and MEL.

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Kulczykowska

2001

Reviews in Fish Biology and Fisheries

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Effect of Methoxyindole Administration on Plasma Cation Levels in the Rat

Cited by 5 publications

References 14 publications

Effects of melatonin on carbon tetrachloride-induced changes in rat serum

Effects of melatonin on carbon tetrachloride-induced changes in rat serum

Effect of melatonin treatment on serum and tissue zinc levels in rats

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