Effect of methanolic extract of Tetrapleura tetraptera (Schum and Thonn) Taub leaves on hyperglycemia and indices of diabetic complications in alloxan–induced diabetic rats

Atawodi, Sunday E.; Yakubu, Ojochenemi Ejeh; Liman, Mubarak Labaran; Iliemene, D. U.

doi:10.12980/apjtb.4.2014c73

Cited by 36 publications

(30 citation statements)

References 18 publications

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“…Okolie et al [62] revealed that the treatment of laboratory mice with extracts of T. tetraptera and vitamin E significantly reduced the levels of liver function biomarkers, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and bilirubin, as well as the antioxidant parameter (MDA) in carbon tetrachloride (CCl 4 )-induced liver injury. In a similar study, the levels of AST and ALT activity were significantly (p < 0.05) reduced when alloxan-diabetic rats were treated with extracts of prekese as compared to the untreated groups [68].…”

Section: Hepatoprotective Activitiesmentioning

confidence: 74%

“…At the experimental dose of 1 mg/kg, prekese leave extract was effective in managing some biomarkers (total and direct bilirubin) compared to glibenclamide. Notably, the extract exhibited a significant percentage change in the fasting blood sugar of normal (non-diabetic) rats compared to diabetic rats [68]. Komlaga [70] also reported the positives effect of ethanolic extract of prekese in lowering blood glucose compared to glibenclamide.…”

Section: Antidiabetic Activitymentioning

confidence: 99%

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Potential Application of Tetrapleura tetraptera and Hibiscus sabdariffa (Malvaceae) in Designing Highly Flavoured and Bioactive Pito with Functional Properties

Adadi

Kanwugu

2020

Beverages

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Sorghum beer (pito) is an indigenous alcoholic beverage peculiar to northern Ghana and parts of other West African countries. It is overwhelmed with calories, essential amino acids (such as lysine, etc.), B-group vitamins, and minerals. In recent years, there has been a growing demand for highly flavoured yet functional pito in Ghana; however, the local producers lack the prerequisite scientific expertise in designing such products. We propose the utilization of Tetrapleura tetraptera (TT) and Hibiscus sabdariffa (HS) as cheap and readily available materials in designing functional flavoured pito. The addition of TT and HS would not alter the fermentation profile but rather augment the starter with nutrients, thus improving the fermentation performance and shelf life of the final pito. In vitro and in vivo studies provide substantive evidence of antioxidant, nephro-and hepato-protective, renal/diuretic effect, anticholesterol, antidiabetic, and antihypertensive effects among others of the TT and HS, hence enriching the pito with health-promoting factors and consequently boosting the health of the consumer. Herein, we summarise the phytochemical, biological, pharmacological, and toxicological aspects of TT and HS as well as the technology involved in brewing the novel bioactive-flavoured pito. In addition, we also report the incidence of heavy metal in conventional pito.

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Section: Hepatoprotective Activitiesmentioning

confidence: 74%

Section: Antidiabetic Activitymentioning

confidence: 99%

Potential Application of Tetrapleura tetraptera and Hibiscus sabdariffa (Malvaceae) in Designing Highly Flavoured and Bioactive Pito with Functional Properties

Adadi

Kanwugu

2020

Beverages

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“…The alterations of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities are biochemical indicators of hepatocellular injuries [17]. The significant increase in serum AST and ALT activities, after exposure of rats to cisplatin may indicate liver injuries, attributed to the adverse effect of this drug.…”

Section: Discussionmentioning

confidence: 99%

“…The significant increase in serum AST and ALT activities, after exposure of rats to cisplatin may indicate liver injuries, attributed to the adverse effect of this drug. Previous studies have shown that increases in serum AST and ALT activities reflect hepatocellular membrane damage and leakage [2,17]. The significant increase in alkaline phosphatase (ALP) activity may also indicate liver impairments and cholestasis, due to the adverse effect of cisplatin.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of aqueous extract of Lophira lanceolata leaf against cisplatin-induced hepatorenal injuries and dyslipidemia in Wistar rats

2020

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Background: Hepatorenal injuries and dyslipidemia are common global health challenges but medicinal plant extracts may have potential to prevent them. Thus, this study evaluated the protective effect of aqueous extract of Lophira lanceolata leaf (LLE) against cisplatin-induced hepatorenal injuries and dyslipidemia in albino Wistar rats. Methods: Thirty rats were randomly divided into 6 groups of 5 rats each. Group I rats received distilled water and served as control, group II rats were given 5 mg/kg cisplatin (CIS) intraperitoneally, groups III and IV rats were treated with 200 and 400 mg/kg LLE respectively for 26 days by oral gavages while groups V and VI rats were treated with 200 and 400 mg/kg LLE respectively, followed by CIS on the 21st day as in group II. About 24 h after treatment, blood was collected from the rats; then serum was separated and used for estimations of biochemical parameters. The kidney and liver of rats were removed, rinsed in normal saline, stored in 10% formalin and used for histological analyses. Results: The biomarkers of hepatic (Aminotransferases, Alkaline phosphatase and Bilirubin) and renal (urea and creatinine) injuries, and dyslipidemia (Total cholesterol, triglycerides and LDL-cholesterol) significantly (p < 0.05) increased in the rats exclusively exposed to cisplatin when compared with normal control. However, treatment of cisplatin-exposed rats with 200 and 400 mg/kg LLE significantly (p < 0.05) reduced the levels of these biomarkers of hepatorenal injuries and dyslipidemia when compared with cisplatin control. Photomicrographs showed pathological signs in the liver and kidney of rats exclusively exposed to cisplatin, but there was moderate protection of these tissues in the rats treated with LLE and cisplatin. Conclusion: The current findings have shown that Lophira lanceolata leaf extract may provide moderate protection against cisplatin-induced hepatorenal injuries and dyslipidemia in albino Wistar rats.

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“…A total of 60 rats were randomly divided into 10 groups of 6 rats each as follows: normal control (feed and water only), untreated diabetic (diabetic control), diabetic + leaf extract (100 mg/kg), diabetic + stem extract (100 mg/kg), diabetic + root extract (100 mg/kg), diabetic + glibenclamide (1 mg/kg), normoglycaemic + leaf extract (100 mg/kg), normoglycaemic + stem extract (100 mg/kg), normoglycaemic + root extract (100 mg/kg), normoglycaemic + glibenclamide (1 mg/kg) [14]. Treatment was orally administered daily for a period of 14 days.…”

Section: Animal Grouping and Treatmentmentioning

confidence: 99%

Antihyperglycaemic and hypolipidemic effect of methanol extracts of <i>Ageratum conyzoides</i> L (Asteraceae) in normal and diabetic rats

Atawodi¹,

Adepoju²,

Nzelibe³

2017

Trop. J. Pharm Res

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Effect of methanolic extract of Tetrapleura tetraptera (Schum and Thonn) Taub leaves on hyperglycemia and indices of diabetic complications in alloxan–induced diabetic rats

Abstract: Methanolic extract of T. tetraptera leaves possesses a potent capacity for treatment of diabetes and the accompanying complications, including oxidative stress and hyperlipidemia.

Cited by 36 publications

References 18 publications

Potential Application of Tetrapleura tetraptera and Hibiscus sabdariffa (Malvaceae) in Designing Highly Flavoured and Bioactive Pito with Functional Properties

Potential Application of Tetrapleura tetraptera and Hibiscus sabdariffa (Malvaceae) in Designing Highly Flavoured and Bioactive Pito with Functional Properties

Protective effect of aqueous extract of Lophira lanceolata leaf against cisplatin-induced hepatorenal injuries and dyslipidemia in Wistar rats

Antihyperglycaemic and hypolipidemic effect of methanol extracts of <i>Ageratum conyzoides</i> L (Asteraceae) in normal and diabetic rats

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