Effect of methamphetamine on ultraweak photon emission and level of reactive oxygen species in male rat brain

Esmaeilpour, Tahereh; Lotfealian, Azam; Anvari, Morteza; Namavar, Mohammadreza; Karbalaei, Narges; Shahedi, Abbas; Bókkon, István; Salari, Vahid; Oblak, Daniel

doi:10.1016/j.neulet.2023.137136

Cited by 3 publications

(3 citation statements)

References 45 publications

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“…Glutamate is a key neurotransmitter in the brain. However, excessive levels of glutamate promotes ROS production in cells, damages mitochondria and DNA in neuronal cells, and causes neuronal cell damage [ 31 ]. Natural products with antioxidant properties neutralize ROS [ 32 , 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Dihydropashanone Isolated from Lindera erythrocarpa, a Potential Natural Product for the Treatment of Neurodegenerative Diseases

Liu,

Yoon,

Lee

et al. 2024

IJMS

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Lindera erythrocarpa, a flowering plant native to eastern Asia, has been reported to have neuroprotective activity. However, reports on the specific bioactive compounds in L. erythrocarpa are finite. The aim of this study was to investigate the anti-neuroinflammatory and neuroprotective effects of the compounds isolated from L. erythrocarpa. Dihydropashanone, a compound isolated from L. erythrocarpa extract, was found to have protected mouse hippocampus HT22 cells from glutamate-induced cell death. The antioxidant and anti-inflammatory properties of dihydropashanone in mouse microglial BV2 and HT22 cells were explored in this study. The results reveal that dihydropashanone inhibits lipopolysaccharide-induced inflammatory response and suppresses the activation of nuclear factor (NF)-κB in BV2 cells. In addition, dihydropashanone reduced the buildup of reactive oxygen species in HT22 cells and induced activation of the nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase (HO)-1 signaling pathway in BV2 and HT22 cells. Our results suggest that dihydropashanone reduces neuroinflammation by decreasing NF-κB activation in microglia cells and protects neurons from oxidative stress via the activation of the Nrf2/HO-1 pathway. Thus, our data suggest that dihydropashanone offers a broad range of applications in the treatment of neurodegenerative illnesses.

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Section: Discussionmentioning

confidence: 99%

Dihydropashanone Isolated from Lindera erythrocarpa, a Potential Natural Product for the Treatment of Neurodegenerative Diseases

Liu,

Yoon,

Lee

et al. 2024

IJMS

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“…Diagnosing AD typically involves a combination of cognitive and memory tests, brain imaging studies, and other assessments performed by a clinician. Based on the observation that the brain spontaneously emits photons, so-called ultraweak photon emissions (UPEs), 1 , 2 we suggest that a brain-computer interface with an integrated photonic chip (BCIPC) 3 may be an efficient real-time method for monitoring early symptoms of AD and related dementias (ADRDs). The envisaged technology would support clinicians by providing complementary data to efficiently screen and diagnose AD.…”

Section: Introductionmentioning

confidence: 99%

Monitoring Alzheimer’s disease via ultraweak photon emission

Sefati,

Esmaeilpour,

Salari

et al. 2024

iScience

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“…Diagnosing AD typically involves a combination of cognitive and memory tests, brain imaging studies, and other assessments performed by a clinician. Based on the observation that the brain spontaneously emits photons, so called ultraweak photon emissions (UPE) (1; 2), we suggest that a brain-computer interface with an integrated photonic chip (BCIPC)(3) may be an efficient real-time method for monitoring early symptoms of AD and related dementias (ADRD). The envisaged technology would support clinicians by providing complementary data to efficiently screen and diagnose AD.…”

Section: Introductionmentioning

confidence: 99%

Monitoring Alzheimer’s Disease via Ultraweak Photon Emission

Sefati

Esmaeilpour

Salari

et al. 2023

Preprint

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The present study takes on an innovative experiment involving detection of ultraweak photon emission (UPE) from the hippocampus of male rat brains and finds significant correlations between Alzheimer's disease (AD), memory decline, oxidative stress, and the intensity of UPE emitted spontaneously from the hippocampus. These remarkable findings opens up novel methods for screening, detecting, diagnosing and classifying neurodegenerative diseases (and associated sydromes), such as in AD. This also paves the way towards novel advanced brain-computer interfaces (BCIs) photonic chip for the detection of UPE from brain's neural tissue. The envisaged BCI photonic chip (BCIPC) would be minimally invasive, cheap, high-speed, scalable, would provide high spatiotemporal resolution of brain's activity and would provide short- and long-term screening of clinical patho-neurophysiological signatures, which could be monitored by a smart wristwatch or smartphone via a wireless connection.

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Effect of methamphetamine on ultraweak photon emission and level of reactive oxygen species in male rat brain

Cited by 3 publications

References 45 publications

Dihydropashanone Isolated from Lindera erythrocarpa, a Potential Natural Product for the Treatment of Neurodegenerative Diseases

Dihydropashanone Isolated from Lindera erythrocarpa, a Potential Natural Product for the Treatment of Neurodegenerative Diseases

Monitoring Alzheimer’s disease via ultraweak photon emission

Monitoring Alzheimer’s Disease via Ultraweak Photon Emission

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