Effect of Metformin Glycinate on Glycated Hemoglobin A1c Concentration and Insulin Sensitivity in Drug-Naive Adult Patients with Type 2 Diabetes Mellitus

Abstract

Administration of metformin glycinate during a 2-month period showed a greater decrease in A1C concentrations than placebo in a selected group of drug-naive adult patients with T2DM.

Efficacy and Safety of Metformin for Patients with Type 1 Diabetes Mellitus: A Meta-Analysis

“…Another meta-analysis has obtained similar results. 18 Metformin was thought to improve the reduced insulin sensitivity in overweight subjects, 19 prediabetes, 20 patients with T2DM, 21 and patients with T1DM. 22 In our metaanalysis, metformin administration significantly decreased the daily insulin dose requirement, indicating that metformin might improve the insulin sensitivity in T1DM.…”

Participation in the Journey to Life Conversation Map Improves Control of Hypertension, Diabetes, and Hypercholesterolemia

“…In addition, the 1.1-point reduction in HbA 1c is comparable to expected reductions from metformin therapy 16 ; thus, in some patients, drug therapy may be delayed with this intervention. In addition, while current guidelines still encourage prescription of statin medications as well as angiotensin-converting enzyme inhibitors for most patients with diabetes, values of both LDL and SBP were lower in the intervention group.…”

Real-World Clinical Experience on the Usage of High-Dose Metformin (1500-2500 mg/day) in Type 2 Diabetes Management

“…Additionally, it is reported to activate the 5′-AMP-activated protein kinase in different tissues, chiefly in liver leading to enhanced insulin sensitivity. 27,28 Role of metformin in reducing blood pressure levels in patients with T2DM is variable; however, a potential of metformin in lowering blood pressure in patients with impaired glucose tolerance or impaired fasting glucose is an established evidence. 4,29,30 In addition, metformin therapy is also linked to improvements in lipoprotein metabolism, as well as in cardiovascular mechanisms such as endothelial dysfunction, oxidative stress, and fat redistribution.…”

“…Additionally, it is reported to activate the 5′-AMP-activated protein kinase in different tissues, chiefly in liver leading to enhanced insulin sensitivity. 27 , 28 …”