2018
DOI: 10.1007/s00213-018-5128-9
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Abstract: Rationale: Epidemiological data suggest that menthol may increase vulnerability to cigarette/ nicotine use and relapse. While menthol's sensory properties are often attributed as the underlying cause of the enhanced vulnerability, an alternative possibility is that they are mediated via pharmacological interactions with nicotine.Objective: This study addressed the possibility that menthol enhances nicotine intake and relapse vulnerability via pharmacological interactions with nicotine using a concurrent intrav… Show more

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Cited by 11 publications
(7 citation statements)
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“…To address behavioral differences in Experiment 1, we compared the number of infusions obtained over the 10-day extended access self-administration period between the five groups later tested under sedentary or exercise conditions using repeated measures ANOVA. Posthoc comparisons to controls (saline, cocaine sedentary) were made using Dunnett's ttests (Nesil et al 2018;Ohlsson et al 2014), and comparisons of the first and last session were made using a paired t-test. These same analyses were also used to compare daily distance run during the first seven exercise sessions, and the number of formerly-active lever responses during the first 6 extinction sessions and during the last extinction session versus the reinstatement session.…”
Section: Discussionmentioning
confidence: 99%
“…To address behavioral differences in Experiment 1, we compared the number of infusions obtained over the 10-day extended access self-administration period between the five groups later tested under sedentary or exercise conditions using repeated measures ANOVA. Posthoc comparisons to controls (saline, cocaine sedentary) were made using Dunnett's ttests (Nesil et al 2018;Ohlsson et al 2014), and comparisons of the first and last session were made using a paired t-test. These same analyses were also used to compare daily distance run during the first seven exercise sessions, and the number of formerly-active lever responses during the first 6 extinction sessions and during the last extinction session versus the reinstatement session.…”
Section: Discussionmentioning
confidence: 99%
“…Univariate ANOVA was used to analyze the group differences in active‐lever responding during extinction and, as a measure of total nicotine‐seeking, active‐lever responding during both extinction and reinstatement. Post hoc comparison to controls (saline sedentary and nicotine sedentary) was made using Dunnett's one‐tailed (for predicted differences in extinction responding) t tests (Nesil, Narmeen, Bakhti‐Suroosh, & Lynch, ; Ohlsson et al., ).…”
Section: Methodsmentioning
confidence: 99%
“…However, another study showed that menthol did not change dopamine release or nicotine self-administration, but did reverse oral nicotine taste aversion in a two-bottle choice test 38 . Besides, Nesil et al 39 concluded from a study in rats that ‘pharmacological interactions of menthol with nicotine reduce, rather than increase, nicotine’s reinforcing effects and some measures of relapse vulnerability’.…”
Section: Evaluation Of Industry Reportsmentioning
confidence: 99%
“…Altogether, a large body of independent literature, except for Nesil et al 39 , supports an intricate interaction between nicotine and menthol, which increases the addictiveness and/or attractiveness of tobacco. This seems consistent with the conclusions by the FDA TPSAC in the comprehensive 2011 report on menthol 40 , stating that there is sufficient evidence to indicate that those who smoke menthol-containing products tend to be more dependent.…”
Section: Evaluation Of Industry Reportsmentioning
confidence: 99%