Effect of melatonin on antioxidant enzyme activities in blood erythrocytes of rats during acute emotional stress

Перцов, С. С.; Kalinichenko, L. S.; Коплик, Е. В.; Nagler, L. G.; Alinkina, E. S.; Kozachenko, A. I.

doi:10.18097/pbmc20156103394

Cited by 9 publications

(6 citation statements)

References 13 publications

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“…The reductions in the markers of oxidative stress, as observed in this study, by quercetin and vitamin C suggest an ability of these potent antioxidants to scavenge free radicals, as previously described by various authors [28,29]. Increased production of free radicals is positively correlated with enhanced vascular tone and consequent hypertension [30].…”

Section: Discussionsupporting

confidence: 86%

Quercetin and Vitamin C Mitigate Cobalt Chloride-Induced Hypertension through Reduction in Oxidative Stress and Nuclear Factor Kappa Beta (NF-Kb) Expression in Experimental Rat Model

Ajibade

Oyagbemi

Omobowale

et al. 2016

Biol Trace Elem Res

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The objective of the present work was to evaluate the toxic effects of cobalt chloride, a potent oxidative stress-inducing chemical, at 650 ppm in rats and the protective effect of quercetin and/or vitamin C against the cobalt chloride-induced toxicity. Thirty rats were randomly selected, and assigned to one of five groups: control, cobalt chloride, cobalt chloride + quercetin, cobalt chloride + vitamin C and cobalt chloride + quercetin + vitamin C. The exposure of rats to cobalt chloride led to a significant increase (p < 0.05) in malondialdehyde (MDA) and hydrogen peroxide (HO) generated, but decreased nitric oxide (NO) bioavailability. Also, significant (p < 0.05) reductions were observed in the activity of glutathione peroxidase (GPx) and reduced glutathione (GSH) content in the cardiac and renal tissues. Treatment with quercetin and vitamin C reversed the effect of cobalt chloride on MDA, HO and NO, more potently than with either of the two antioxidants, and increased the antioxidant defence system. Further, treatment of rats with quercetin and vitamin C in combination resulted in significant (p < 0.05) decreases in the systolic, diastolic, and mean arterial blood pressure of rats, relative to those exposed to cobalt chloride alone. Immunohistochemical studies revealed a greater expression of nuclear factor kappa beta (NF-kB) in the cobalt chloride group compared with the control- and antioxidants-treated rats. The results of this study suggest a protective role for quercetin and vitamin C in the amelioration of the toxic mechanisms leading to cobalt chloride-induced hypertension and its associated cardiac and renal complications in rats.

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Section: Discussionsupporting

confidence: 86%

Quercetin and Vitamin C Mitigate Cobalt Chloride-Induced Hypertension through Reduction in Oxidative Stress and Nuclear Factor Kappa Beta (NF-Kb) Expression in Experimental Rat Model

Ajibade

Oyagbemi

Omobowale

et al. 2016

Biol Trace Elem Res

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“…Местом синтеза мелатонина является эпифиз, клетки APUD-системы пищеварительного тракта, а также другие неэндокринные клетки -тучные, эозинофилы, тромбоциты, эндотелиоциты [5,6]. Он обладает широким спектром физиологических эффектов.…”

Section: Introductionunclassified

Participation of melatonin in regulation of blood oxygen-transport function in oxidative stress induced by injection of lipopolisaccharide

Зинчук

Firago

2017

BIOMED KHIM

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The contribution of melatonin to the regulatoin of the blood oxygen transport function was studied during oxidative stress induced by a triple injection of lipopolysaccharide (at a dose of 5 mg/kg) in conditions of erythropoietin and gasetransmitters (nitrogen monoxide, hydrogen sulfide) action. In the experimental groups, intraperitoneal injections of melatonin (5 mg/kg), erythropoietin (1000 U/kg), hydrogen sulfide donor (NaHS 5 mg/kg), and L-arginine (100 mg/kg), were performed. The use of melatonin alone or in combination with erythropoietin, sodium hydrosulfide or L-arginine led to a decrease in lipid peroxidation products and an increase in the antioxidant protection. Melatonin, during lipopolysaccharide administration, caused changes of blood oxygen transport function: blood oxygen saturation increased, hemoglobin oxygen affinity increased. The modifying effect of melatonin on the blood oxygen transport function in combination with erythropoietin and gastransmitters did not exceed the effect of melatonin alone.

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“…As a potent antioxidant, melatonin and its metabolites directly scavenge a variety of free radicals [12, 13]. There is ample evidence suggesting that melatonin possesses both antioxidative and anti-inflammatory effects [14–16].…”

Section: Introductionmentioning

confidence: 99%

Melatonin Suppresses Toll Like Receptor 4-Dependent Caspase-3 Signaling Activation Coupled with Reduced Production of Proinflammatory Mediators in Hypoxic Microglia

Yao

Ling

2016

PLoS ONE

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Microglia activation and associated inflammatory response play pivotal roles in the pathogenesis of different neurodegenerative diseases including neonatal hypoxic brain injury. Here we show that caspase3 expression was upregulated in activated microglia after hypoxic exposure, and remarkably, the cell viability remained unaffected alluding to the possibility of a non-apoptotic role of caspase3 in activated microglia. Chemical inhibition of caspase3 suppressed microglia activation as evident by an obvious reduction in expression of proinflammatory mediators and NF-κB signaling activation. Hypoxia induced caspase3 activation was TLR4 dependent as supported by the fact that caspase3 activation was hindered in cells with TLR4 knockdown. Interestingly, melatonin treatment significantly suppressed caspase3 activation. More importantly, melatonin also inhibited the increase in TLR4 protein and mRNA expression in hypoxic microglia. Inhibition of TLR4 expression by melatonin was also found in microglia of postnatal rats subjected to hypoxic exposure. Taken together, it is concluded that melatonin could inhibit TLR4 expression in hypoxic microglia followed by suppression of caspase3 activation leading to decrease in production of proinflammatory mediators.

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Effect of melatonin on antioxidant enzyme activities in blood erythrocytes of rats during acute emotional stress

Cited by 9 publications

References 13 publications

Quercetin and Vitamin C Mitigate Cobalt Chloride-Induced Hypertension through Reduction in Oxidative Stress and Nuclear Factor Kappa Beta (NF-Kb) Expression in Experimental Rat Model

Quercetin and Vitamin C Mitigate Cobalt Chloride-Induced Hypertension through Reduction in Oxidative Stress and Nuclear Factor Kappa Beta (NF-Kb) Expression in Experimental Rat Model

Participation of melatonin in regulation of blood oxygen-transport function in oxidative stress induced by injection of lipopolisaccharide

Melatonin Suppresses Toll Like Receptor 4-Dependent Caspase-3 Signaling Activation Coupled with Reduced Production of Proinflammatory Mediators in Hypoxic Microglia

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