Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk

Llorente‐Cortés, Vicenta; Estruch, Ramón; Mena, Mari Pau; Ros, Emilio; González, Miguel Ángel Martínez; Fitó, Montserrat; Lamuela‐Raventós, Rosa María; Badimon, Lina

doi:10.1016/j.atherosclerosis.2009.08.004

Cited by 145 publications

(94 citation statements)

References 54 publications

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“…The results showed that a Nordic diet leads to a reduced expression of genes that code for inflammatory markers. These results concur with the results from a study on the Mediterranean diet, showing that Mediterranean foods may modulate the expression of genes that code for proatherogenic factors in adipose tissue (45). In the SYSDIET study, the expression of inflammatory genes in peripheral leukocytes after a glucose tolerance test was reduced by a Nordic diet, but the clinical importance of this finding for the development of metabolic syndrome remains uncertain (26).…”

Section: Inflammationsupporting

confidence: 80%

Anbefalt nordisk kosthold og risikomarkører for hjerte- og karsykdom

Berild¹,

Holven²,

Ulven³

2017

Tidsskriftet

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Section: Inflammationsupporting

confidence: 80%

Anbefalt nordisk kosthold og risikomarkører for hjerte- og karsykdom

Berild¹,

Holven²,

Ulven³

2017

Tidsskriftet

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“…The study found a significant reduction in systolic and diastolic blood pressure of 7 and 3 mmHg, respectively. This study used a large cohort of 772 participants; subgroups of this study with 49-106 participants also reported similar reductions in blood pressure (67,84,85) . A larger cohort of the PREDIMED Trial found only a significant reduction in diastolic blood pressure (83) .…”

Section: G/d Hazelnuts Vcam (A) (B) Ns Ns-i; 0·1 Vcam (C) Ns Ns-i; 0·mentioning

confidence: 99%

Nut consumption for vascular health and cognitive function

et al. 2014

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Nuts are rich in many nutrients that can benefit multiple cardiometabolic functions, including arterial compliance, blood pressure, inflammation, glucoregulation and endothelial vasodilatation. Impaired vasodilatation may contribute to impaired cognitive performance due to poor cerebral perfusion. The present narrative review examines associations between nut consumption, vascular health and cognitive function. It includes a systematic search which identified seventy-one epidemiological or intervention studies in which effects of chronic nut consumption on blood pressure, glucoregulation, endothelial vasodilator function, arterial compliance, inflammatory biomarkers and cognitive performance were evaluated. Weighted mean changes were estimated where data were available; they indicate that nut consumption reduces blood pressure and improves glucoregulation, endothelial vasodilator function and inflammation, whilst a limited number of studies suggest that nut consumption may also improve cognitive performance. Further clinical trials are warranted to explore relationships between nut consumption, endothelial function and cognitive function.

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“…The Mediterranean diet is associated with improvements in lipid profile, blood pressure, and other well-known CVD risk factors [24]. It is rich in antioxidant and antiinflammatory substances, and has been related to the reduction in the expression of several proatherogenic genes involved in vascular inflammation, foam cell formation and thrombosis, and increase of serum markers of atheroma plaque stability [25,26]. Several components of the Mediterranean diet may play a significant role in CVD prevention.…”

Section: Level Of Adherence To the Mediterranean Dietmentioning

confidence: 99%

Mediterranean Diet and 10-year (2002-2012) Incidence of Diabetes and Cardiovascular Disease in Participants with Prediabetes: The ATTICA study

et al. 2016

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■ AbstractBACKGROUND: Prediabetes has been related to an increased risk of developing diabetes and cardiovascular disease (CVD). AIM: The aim of the present study was to examine the effect of the Mediterranean diet on diabetes and CVD risk in subjects with impaired fasting glucose (IFG, i.e. fasting plasma glucose 100-125 mg/dl). METHODS: During 2001-2002, 3042 men and women (>18y) were enrolled for the study. The participants showed no clinical evidence of CVD or any other chronic disease, and were living in the greater Athens (Greece) area. In 2011 and 2012, the 10-year follow-up examinations were performed, including a working sample of n = 1875 participants without diabetes at baseline. Adherence to the Mediterranean diet at baseline evaluation was assessed using the MedDietScore (range 0-55). RE-SULTS: The prediabetic subjects (n = 343) had a significantly higher incidence of diabetes (25% vs. 10%, p < 0.001) and CVD (17.8% vs. 12.3%, p = 0.007) compared with subjects with normal glucose values. A significant trend towards lower diabetes and CVD incidence was observed with medium and high adherence to the Mediterranean diet compared with low adherence (p < 0.001). High adherence to the Mediterranean diet (>35/55 score) was associated with lower 10-year incidence of diabetes and CVD. In multiple logistic regression models, participants with high levels of adherence to the Mediterranean diet were significantly less affected by diabetes and CVD than those with low adherence levels. CONCLUSION: High adherence to the Mediterranean diet is associated with a low risk of developing diabetes and CVD in prediabetic subjects.

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Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk

Cited by 145 publications

References 54 publications

Anbefalt nordisk kosthold og risikomarkører for hjerte- og karsykdom

Anbefalt nordisk kosthold og risikomarkører for hjerte- og karsykdom

Nut consumption for vascular health and cognitive function

Mediterranean Diet and 10-year (2002-2012) Incidence of Diabetes and Cardiovascular Disease in Participants with Prediabetes: The ATTICA study

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