Effect of medical expulsive therapy on the health-related quality of life of patients with ureteral stones: a critical evaluation

Eryıldırım, Bilal; Şahin, Cahit; Tuncer, Murat; Sabuncu, K.; Cetinel, Cihangir; Tarhan, Fatih; Sarıca, Kemal

doi:10.1007/s11255-015-1036-7

Cited by 13 publications

(16 citation statements)

References 21 publications

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“…In brief, there was not any significant difference between group A and B in stone free rate, despite the fact that it was higher in group B. Also, in our study, stone clearance rate was lower in comparison with the most earlier studies in groups received tamsulosin (1)(2)(3)(4)(5)12,14,15,(17)(18)(19)(20)(21)(22). Unfortunately, we did not find any similar study to compare our results with it.…”

Section: Discussioncontrasting

confidence: 71%

“…Unfortunately, we did not find any similar study to compare our results with it. But our study was different from others because of 1) shorter follow up period (2 weeks vs 3-12 weeks in other studies) (1-6,12-23), 2) attendance of patients with more than one stone in different parts of kidney in spite of other studies (1)(2)(3)(4)6,14,16,18,19,21,22). Additionally, it is obvious that stone location, size, number and structure, presence of ureteral spasm, mucosal edema or inflammation and ureteral anatomy are the factors influencing stone clearance rate (1).…”

Section: Discussioncontrasting

confidence: 67%

“…Urolithiasis is one of the most common problem in referred patients to urologic clinic and emergency room (1,2). The present study investigated the beneficial effects and safety of tamsulosin versus tamsulosin plus lithorex-B in patients with renal and upper ureteral stone after successful SWL.…”

Section: Discussionmentioning

confidence: 98%

“…A sample size of 58 patients was calculated using comparing two proportion formulas. It was estimated to yield 80% power (type II or beta error of 0.20%) to detect a difference of 20% or more between two groups (70% expulsion rate in tamsulosin group (1)(2)(3)(4)(5) and 90% in tamsulosin plus lithorex -B group), allowing 5% of type I error. Totally, 64 patients were enrolled in the study.…”

Section: Methodsmentioning

confidence: 99%

“…Urolithiasis is one of the most common disorders of urinary system and allocates more than one million visits to physician and emergency room annually (1). Urolithiasis affects about 5%-15% of population worldwide (2)(3)(4). The incidence of urolithiasis is higher in the Middle East, western India and southern USA (1).…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of tamsulosin versus tamsulosin plus lithorex-B as medical expulsive therapy following extracorporeal shock-wave lithotripsy of renal and upper ureteric stones; a randomized clinical trial

Mehrabi¹,

Manzouri²,

Kohzadi³

et al. 2017

J Nephropharmacol

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Implication for health policy/practice/research/medical education:Further studies are necessary to provide comparison between tamsulosin and lithorex-B in separate groups for deciding about treatment with lithorex-B.Please cite this paper as: Mehrabi S, Manzouri L, Kohzadi A Mehrabi F. Efficacy of tamsulosin versus tamsulosin plus lithorex-B as medical expulsive therapy following extracorporeal shock-wave lithotripsy of renal and upper ureteric stones; a randomized clinical trial.Introduction: Urolithiasis is one of the most common disorders of urinary system. Objectives: To compare the efficacy and safety of tamsulosin versus tamsulosin plus lithorex-B. Patients and Methods:This study was an open-label, randomized, controlled trial conducted in Yasuj University of Medical Sciences, Iran in 2014 to 2015. After taking informed consent, a total of 64 patients aged 18 years and over, presenting with renal or upper ureteral stones up to 20 mm in diameter were enrolled in this study. After extracorporeal shock-wave lithotripsy (SWL), patients were randomly assigned to group A (n = 32) received tamsulosin 0.4 mg and group B (n = 32) received tamsulosin 0.4 mg plus lithorex-B 400 mg orally at bed time daily for 2 weeks. Finally, patients were assessed by KUB and sonography. The stone passage rate, drug adverse effects and pain score were evaluated. All data were analyzed using SPSS 21. Results: There were no significant differences between group A and B regarding stone expulsion rates (40.6% vs 43.7%, P = 0.83), adverse effects (34.4% vs 40.6%, P = 0.79) and mean score of pain (4.31 ± 2.02 vs 5 ± 2.01, P = 0.17) after 2 weeks follow up. Primary stone size was the predicting factor of stone passage (β = -0.42, P = 0.005, Exp (β) = 0.65, CI 95%, Exp (β): 0.48-0.88). Conclusion: Tamsulosin plus lithorex-B is safe and well tolerated with no extra benefit regarding the expulsion rate in 2 weeks follow up. Hence, the necessity of conducting a trial with a longer follow up period providing comparison between tamsulosin and lithorex-B in separate group is felt.

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