Effect of matrine on the expression of substance P receptor and inflammatory cytokines production in human skin keratinocytes and fibroblasts

Liu, Jiyong; Jin-hong, HU; Zhu, Quangang; Li, Feng-Qian; Wang, Jing; Sun, Hao

doi:10.1016/j.intimp.2007.02.003

Cited by 80 publications

(59 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Three new articles were retrieved this way, for a total of 13 articles concerning the action of CGRP and/or SP on cultured human skin fibroblasts, of which 12 were related to SP and 1 was related to both CGRP and SP. A summary of the content of these articles is shown in Table 1 [30,[50][51][52][53][54][55][56][57][58][59][60][61]. A schematic drawing is proposed showing the molecular mechanisms of CGRP and SP in human skin fibroblasts and is shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

The action of CGRP and SP on cultured skin fibroblasts

Hochman

Tucci-Viegas²,

Monteiro

et al. 2014

Open Life Sciences

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

The action of CGRP and SP on cultured skin fibroblasts

Hochman

Tucci-Viegas²,

Monteiro

et al. 2014

Open Life Sciences

View full text Add to dashboard Cite

show abstract

“…(21). The pharmacological effects of matrine have been extensively documented in viral hepatitis (21,22), cardiac arrhythmia (23) and atopic dermatitis (24). The antitumor activity of matrine has also been recently documented.…”

Section: Introductionmentioning

confidence: 99%

Matrine inhibits proliferation and induces apoptosis of the androgen‑independent prostate cancer cell line PC-3

et al. 2011

View full text Add to dashboard Cite

Abstract. Current strategies to treat androgen-independent prostate cancer are associated with a number of challenges and are not yet curative. Matrine is a naturally occurring alkaloid extracted from the Chinese herb Sophora flavescens. Matrine has shown anti-proliferative properties in a number of types of cancer, including breast, gastric, lung and pancreatic tumors. Matrine was also found to promote apoptosis and inhibit invasion of cancer cells. We evaluated the antitumor effects of matrine on androgen-independent PC-3 prostate cancer cells. The effects of matrine on cell cycle progression and apoptosis of PC-3 cells were tested. Matrine-treated PC-3 cells underwent G0/G1 cell cycle arrest. There was a significant reduction in the number of S phase and G2/M phase cells in the treated group when compared to untreated cells. Flow cytometry, as well as Annexin-V/PI staining, showed a significant, dose-dependent increase in the number of early, as well as late, stage apoptotic cells in matrine-treated cells compared to untreated cells. There was also an increase in the number of necrotic cells in the matrine-treated group when compared to untreated cells. Matrine treatment resulted in increased levels of caspase-3 and Bax and decreased levels of Bcl-2. Our data suggest that matrine inhibits the proliferation of androgen-independent prostate cancer cells by causing G0/ G1 cell cycle arrest and promoting apoptosis. Matrine-induced apoptosis was mediated by downregulation of Bcl-2/Bax ratios and upregulation of caspase-3 levels. Based on our data, we suggest that matrine may be a novel addition to the current arsenal of strategies used to treat androgen-independent prostate cancer.

show abstract

“…Matrine is one of the main alkaloid components extracted from the Sophora root, which was first isolated and identified in 1958 from Sophora flavescens Ait, subprostrata and alopecuroides [3][4][5][6]. Matrine and its derivatives are known for their importance in pharmaceutical and agricultural applications because of their biological activities, such as anticancer, anti-inflammatory, antimicrobial, antiviral and insecticidal activity [7][8][9][10][11].…”

Section: Commentmentioning

confidence: 99%

The crystal structure of the Matrine derivative: 12-(1H-indol-1-yl)dodecahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one hydrate, C₂₃H₂₉N₃O

Cheng

Liu

Wei-Xin

et al. 2017

Zeitschrift Für Kristallographie - New Crystal Structures

View full text Add to dashboard Cite

Tables 1 and 2 contain details on the crystal structure and measurement conditions and a list of the atoms including atomic coordinates and displacement parameters. Source of materialsThe synthesis of the title compound was carried out using the michael addition reaction. A mixture of sophocarpine (1.3 g, 5.0 mmol), indole (0.9 g, 8 mmol) and cesium chloride (0.8 g, 5 mmol) was dissolved in 12 mL petroleum

show abstract

Effect of matrine on the expression of substance P receptor and inflammatory cytokines production in human skin keratinocytes and fibroblasts

Cited by 80 publications

References 34 publications

The action of CGRP and SP on cultured skin fibroblasts

The action of CGRP and SP on cultured skin fibroblasts

Matrine inhibits proliferation and induces apoptosis of the androgen‑independent prostate cancer cell line PC-3

The crystal structure of the Matrine derivative: 12-(1H-indol-1-yl)dodecahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one hydrate, C₂₃H₂₉N₃O

Contact Info

Product

Resources

About

Effect of matrine on the expression of substance P receptor and inflammatory cytokines production in human skin keratinocytes and fibroblasts

Cited by 80 publications

References 34 publications

The action of CGRP and SP on cultured skin fibroblasts

The action of CGRP and SP on cultured skin fibroblasts

Matrine inhibits proliferation and induces apoptosis of the androgen‑independent prostate cancer cell line PC-3

The crystal structure of the Matrine derivative: 12-(1H-indol-1-yl)dodecahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one hydrate, C23H29N3O

Contact Info

Product

Resources

About

The crystal structure of the Matrine derivative: 12-(1H-indol-1-yl)dodecahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one hydrate, C₂₃H₂₉N₃O