Effect of maternal zinc supplementation or zinc status on pregnancy complications and perinatal outcomes: An umbrella review of meta-analyses

Iqbal, Sehar; Ali, Inayat

doi:10.1016/j.heliyon.2021.e07540

Cited by 18 publications

(13 citation statements)

References 52 publications

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“…Cochrane database reviewed the role of zinc supplementation in 14% reduction of preterm birth (risk ratio (RR) 0.86, 95% confidence interval (CI) 0.76 to 0.97 in 16 randomized controlled trials (RCTs); 16 trials of 7637 women from low‐ and middle‐income settings with a high prevalence of zinc deficiency and perinatal mortality 106 . This is consistent with the findings of Terrin et al 27 Recent review by Iqbal and Ali 107 also found a significant relationship between low maternal zinc status and risk of pregnancy complications. Preterm babies, who are born with low zinc stores and with diminished capacity for zinc absorption and retention, could benefit from zinc supplements as an easily implemented intervention for growth, immune function and decreased morbidity 108 .…”

Section: Zinc Supplementation and Preterm Birthsupporting

confidence: 64%

Zinc homeostasis in immunity and its association with preterm births

2022

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Preterm birth is among the most common adverse pregnancy outcomes and is the leading cause of neonatal mortality and morbidity. While trace elements are essential for humans, their specific roles in the prenatal period remain unexplored. Zinc, a ubiquitous element, plays a pivotal role in protein synthesis, cell division, nucleic acid metabolism, apoptosis, ageing, reproduction, immunological and antioxidant defence mechanism. Although zinc quantities are very small in body tissue, it is involved in every conceivable biochemical pathway, which is critical for the performance of various functions necessary to sustain life. Owing to the multifactorial role of zinc, it is not possible to attribute a certain zinc‐dependent mechanism in preterm births. Although the effect of zinc deficiency on immunity, its impact on maternal function and health as well as its role in the developing foetus is well documented, much less attention has been given to the understanding of micronutrient zinc homeostasis in immunity and its association with preterm births. Despite extensive research, the pathway by which zinc regulates pregnancy outcomes as well as the function of immune cells in controlling the delivery status (term/preterm) is still obscure. The present review aims to focus on the understanding of relationship of micronutrient zinc homeostasis in immunity and its association with preterm births.

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Section: Zinc Supplementation and Preterm Birthsupporting

confidence: 64%

Zinc homeostasis in immunity and its association with preterm births

2022

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“…Several studies have also discovered that mothers who give birth to babies with LBW tend to have lower serum zinc levels than mothers who give birth to babies with normal birth weight; in this case, the lower maternal serum zinc levels are positively associated with lower birth weight [40]. A study which was carried out by Iqbal demonstrated a significant relationship between maternal zinc levels and the risk of pregnancy complications [41].…”

Section: Serum Zinc Levels For Pregnant Womenmentioning

confidence: 99%

The Effect of Pumpkin Seed Biscuits on Nutritional and Zinc Status: A Randomized Controlled Trial in Pregnant Women

Syakur

Syam²,

Hadju³

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: In several studies in Indonesia, low birth weight (LBW) is shown as the most dominant risk factor for stunting. Some of the causes of LBW are chronic energy deficiency during pregnancy, anemia during pregnancy, lack of nutrient supply during pregnancy, pregnancy complications, maternal parity, and birth spacing. In this case, women commonly suffer from micronutrient deficiencies including iodine, iron, Vitamin A, zinc, and folate. Related to this, about 80% of pregnant women in the world fulfill normative pregnancy needs due to inadequate zinc intake. One source of micronutrients rich in zinc is pumpkin seeds. The nutritional potential of pumpkin seeds is realized in the form of food products for pregnant women, including amino acids. One example of pumpkin seed fortification has been assessed in biscuit products by trained panelists and consumers, obtaining results that 20% additional pumpkin seed flour to biscuits becomes the best treatment. Meanwhile, in the case of this study, we expect that the pumpkin seed biscuits provided can increase the energy intake in pregnant women because when pumpkin seeds are added, the nutrition contained in the biscuits is also increased, in this case, the nutrition includes the zinc and Fe. AIM: The purpose this research is to figure out how pumpkin seed biscuits affect pregnant women concerning their nutrition status and serum zinc levels. METHODS: The method employed was a double-blind and randomized experimental research involving pre- and post-test control groups. The inclusion criteria of the participants involved were pregnant women aged 20–35 years old who were at their first and second trimesters of pregnancy and parity one to three and singleton pregnancy. Meanwhile, the exclusion criteria of the participants were pregnant women suffering from severe complications. There were 89 pregnant women further gathered in this study, but only 66 of them met the criteria and idled into two groups. In this case, one group received the pumpkin seed biscuit intervention, while the other received placebo biscuits. The intervention was conducted for 90 days where the pregnant women were provided with four biscuits for daily consumption. RESULTS: The nutritional status parameter of pregnant women involved in the current research was assessed, including body weight, mid-upper arm circumference (MUAC), and serum zinc levels. In this case, the average serum zinc level obtained was 48.75 g/dL from 60 pregnant women. Furthermore, a significant increase occurred in nutritional status for each group, marked by body weight gain, and increased MUAC. However, no significant difference emerged between the pumpkin seed biscuit group and the placebo biscuit group with p = 0.914 and p = 0.916, respectively. A significant increase in zinc levels was observed in both groups. In this case, changes in zinc levels between the two groups were significantly different (13.72 ± 1.84 vs. 9.81 ± 11.81, p = 0.007). CONCLUSION: Giving pumpkin seed biscuits contribute to weight gain and increase the MUAC the pregnant women which, in turn, improves their nutritional status and serum zinc.

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“…This result in line acwith the theory which states that animal foods do not contain a lot of phytates so that zinc can be absorbed optimally. Fiber and phytic acid will inhibit zinc bioavailability (Iqbal and Ali, 2021).…”

Section: Discussion a Correlation Between Zinc Intake With Hemoglobin...mentioning

confidence: 99%

Correlation between Zinc and Folic Acid Intake with Hemoglobin Levels in Pregnancy

2022

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The deficiency of micronutrients and anemia are nutritional problems in pregnancy. WHO in 2019 and Riskesdas in 2018 reported that anemic pregnant women in Indonesia were 44.2% and 48.9%. Public Health Service also reported there was an increased prevalence of this problem in West Sumatra and Padang City in 2019 which was 18.1% and 11.2%. Micronutrient deficiency affected the hemoglobin (Hb) level, which is one of the indicators marking anemia in pregnancy. The objective was to determine the correlation between zinc and folic acid with hemoglobin levels in the third trimester of pregnancy. This analytical cross-sectional research was held in the Health Center and laboratory of Lubuk Kilangan on May-July 2022. The population and samples were 64 third-trimester pregnant women with total sampling. Intake data were collected through interviews using the Food Frequency Questionnaire (FFQ). Hemoglobin levels were examined by a hematology analyzer. Pearson correlation was used to identify the correlation of the variables (P< 0.05) . The mean levels of zinc and folic acid intake and hemoglobin levels were 7.35 mg, 215.56 mcg, and 11.08 g/dL. There was a positive correlation between zinc (p=0,015) and folic acid (p=0.004) with hemoglobin levels in the third trimester of pregnancy.

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Effect of maternal zinc supplementation or zinc status on pregnancy complications and perinatal outcomes: An umbrella review of meta-analyses

Cited by 18 publications

References 52 publications

Zinc homeostasis in immunity and its association with preterm births

Zinc homeostasis in immunity and its association with preterm births

The Effect of Pumpkin Seed Biscuits on Nutritional and Zinc Status: A Randomized Controlled Trial in Pregnant Women

Correlation between Zinc and Folic Acid Intake with Hemoglobin Levels in Pregnancy

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