Effect of maternal iron status on the number of CD34+ stem cells harvested from umbilical cord blood

Abstract

This study indicates that lower numbers of CD34+ cells are more likely to occur when collected from mothers with higher SF. This finding suggests that maternal SF and associated iron status play a significant, but as yet undefined, role in the generation of CD34+ cells in UCB.

Associated factors of umbilical cord blood collection quality

“…Most of blood iron variables (Hb, hematocrit, transferrin, iron, total iron‐binding capacity, and iron saturation) did not seem to influence UCB quality . Only serum ferritin showed some negative correlation with CD34+ cell count . These variables are useless in predicting UCB quality.…”

“…Six articles conclude with an increase in Cesarean delivery 10,17,42,59,67,68 and with the same number for vaginal deliveries. 15,22,32,36,44,64 There was a significant higher count in natural delivery than cesarean section in half of these articles. 15,22,32,44,64 Reaching a final conclusion is therefore not possible because of the result disparities.…”

“…In the study by Shlebak and coworkers, Hb influenced TNC concentration. Pope and colleagues also showed that transferrin, iron, total iron‐binding capacity, iron saturation, and C‐reactive protein had no influence on UCB characteristics while serum ferritin was negatively correlated with CD34+ cells quantity. On the whole, iron‐related variables do not appear to play a role on UCB quality.…”

“…Maternal age at delivery has been analyzed in 28 of 71 articles . In most articles, no significant correlation was found with UCB volume, TNCs, CD34+ cells, or CFU (Fig.…”

“…Fifteen articles found that vaginal delivery led to better cord blood quality than Cesarean delivery. 15,22,27,32,33,[36][37][38]40,44,49,[62][63][64][65] In 10 different articles opposite results were found, 10,18,24,42,56,58,59,66-68 while contrasting results were found in seven articles. 17,31,35,48,50,52,69 In five studies, no significant influence of delivery type on UCB quality 9,19,29,45,47 was found.…”