Effect of Marginal Maternal Zinc Intake on Zinc Absorption and Growth of 3-September-Old Infant Rhesus Monkeys

Lönnerdal, Bo; Keen, Carl L.; Bell, Janet G.; Golub, Mari S.; Hendrickx, Andrew G.; Gershwin, M. Eric

doi:10.1001/archpedi.1990.02150330067023

Arch Pediatr Adolesc Med

1990

DOI: 10.1001/archpedi.1990.02150330067023

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Effect of Marginal Maternal Zinc Intake on Zinc Absorption and Growth of 3-September-Old Infant Rhesus Monkeys

Bo Lönnerdal

Carl L. Keen

Janet G. Bell

et al.

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Cited by 2 publications

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“…These studies have also revealed a compensatory increase in Zn absorption during pregnancy reducing the effects of low Zn intake (21). We have also shown that maternal Zn deficiency can affect Zn absorption in infants born from these monkeys (21,22). To characterize further factors influencing Zn status, we tested the hypothesis that dietary iron (Fe) affects Zn absorption (23).…”

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confidence: 93%

Effect of Infant Formula Zinc and Iron Level on Zinc Absorption, Zinc Status, and Immune Function in Infant Rhesus Monkeys

Polberger,

Fletcher,

Graham

et al. 1996

J. pediatr. gastroenterol. nutr.

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SummaryTo evaluate the effects of marginal zinc (Zn) deficiency on Zn absorption and metabolism, three groups of infant rhesus monkeys (n = 4/group) were fed from birth to 5 months of age either a regular infant formula (5 mg Zn/L) or a low‐Zn formula (1 mg Zn/L). Since iron (Fe) intake may affect Zn absorption, the low‐Zn formula was given without (1 mg Fe/L) or with Fe fortification (12 mg/L). At monthly intervals, Zn absorption and retention were assessed by gavage feeding with 65Zn and whole‐body counting immediately after and on days 4, 7, and 11 after intubation. Blood samples were drawn before dosing for analyses of various potential markers of Zn status. Infants fed low‐Zn formula had slower weight gain than controls; however, length growth was similar in all groups. 65Zn retention was considerably higher in both groups fed low‐Zn formula (40%) than in the control group (20%), whereas plasma Zn levels were normal in all infants. Plasma metallothionein levels were generally very low and detectable in only 5 samples of 48; however, 4 of these were found in control infants. Neutrophil chemotaxis assessed at the end of the study was impaired in low‐Zn infants compared to controls. In addition, low‐Zn infants had increased levels of interleukin‐2 at the end of the study. No differences were seen between the groups in hemoglobin levels, total white blood cells/absolute neutrophil counts, or plasma activities of 5′‐nucleotidase or angiotensin converting enzyme. In conclusion, marginal Zn intake in infant rhesus monkeys resulted in increased Zn retention, which was not enough to completely compensate for the lower Zn intake. The higher level of iron fortification studied did not affect Zn retention significantly.

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mentioning

confidence: 93%

Effect of Infant Formula Zinc and Iron Level on Zinc Absorption, Zinc Status, and Immune Function in Infant Rhesus Monkeys

Polberger,

Fletcher,

Graham

et al. 1996

J. pediatr. gastroenterol. nutr.

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Effect of a zinc-fortified formula on immunocompetence and growth of malnourished infants

Schlesinger

Arévalo

Arredondo

et al. 1992

The American Journal of Clinical Nutrition

111

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This study attempted to define the possible contribution of zinc nutrition to immunocompetence and growth in severely malnourished infants. The effect of zinc supplementation was evaluated in marasmic infants during nutritional rehabilitation by using a controlled double-blind design in which 19 infants fed a zinc-fortified formula were compared with 20 infants fed the same non-supplemented formula. Evaluation of immunocompetence, growth, and zinc, copper, and iron status was performed on admission and at 30, 60, and 105 d of nutritional rehabilitation. Although energy intake was similar in both groups, the zinc-supplemented infants had significantly higher linear growth gain, and their immune function improved as demonstrated by conversion of their delayed hypersensitivity skin reactions, enhanced lymphoproliferative response to PHA, and increased salivary IgA concentrations. Thus, the use of a zinc-fortified formula during nutritional rehabilitation can prevent the development of zinc deficiency and improve growth and immune function.

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Effect of Marginal Maternal Zinc Intake on Zinc Absorption and Growth of 3-September-Old Infant Rhesus Monkeys

Cited by 2 publications

References 24 publications

Effect of Infant Formula Zinc and Iron Level on Zinc Absorption, Zinc Status, and Immune Function in Infant Rhesus Monkeys

Effect of Infant Formula Zinc and Iron Level on Zinc Absorption, Zinc Status, and Immune Function in Infant Rhesus Monkeys

Effect of a zinc-fortified formula on immunocompetence and growth of malnourished infants

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