Effect of manganese and manganese plus noise on auditory function and cochlear structures

Muthaiah, Vijaya Prakash Krishnan; Chen, Guang-Di; Ding, Dalian; Salvi, Richard; Roth, Jerome A.

doi:10.1016/j.neuro.2016.05.014

Cited by 8 publications

(7 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In conclusion, Mn exposure affects sensory function in mice and rats with effects seen at doses as low as 3.0 mg/kg bw (Horvath et al, 2012;Ohgami et al, 2016); while at higher doses or longer exposures behavioural changes were observed (Dorman et al, 2000;Ohgami et al, 2016). This is supported by findings from single dose studies (Muthaiah et al, 2016;Takacs et al, 2012). Effects of Mn exposure on motor function in adult animals appear less pronounced, as only one multiple-dose study examined motor function and found no effects, while several single dose studies showed detrimental effects of Mn exposure on motor function at rather low doses (≤16.7 mg Mn/kg bw) using rotarod test (Avila et al, 2010;Freeman et al, 2020) or grip strength (Nkpaa, Awogbindin, et al, 2019).…”

Section: Loe1: Motor and Sensory Functions Endpointsmentioning

confidence: 86%

“…et al, 2022). Three studies were conducted in mice (Freeman et al, 2020;Krishna et al, 2014;Wilcox et al, 2022) and five studies in rats (Avila et al, 2010;Muthaiah et al, 2016;Nkpaa, Awogbindin, et al, 2019;Takacs et al, 2012;Zhang et al, 2021).…”

Section: Loe1: Motor and Sensory Functions Endpointsmentioning

confidence: 99%

“…A single study on rats tested and found that Mn impaired negative geotaxis in males after exposure to 8.3 mg Mn per kg bw for 35 days (Nkpaa, Awogbindin, et al, 2019). Two studies on rats investigated sensory function by assessing hearing measurements (Muthaiah et al, 2016) and cortical electrical activity (Takacs et al, 2012) after exposure to 351.3 mg Mn for 90 days or 86.8 mg Mn for 4 weeks, respectively. Both studies found reduction in measured parameters.…”

Section: Loe1: Motor and Sensory Functions Endpointsmentioning

confidence: 99%

See 2 more Smart Citations

Preparatory work for the update of the tolerable upper intake levels for manganese

Halldorsson,

Birgisdottir,

Dudele

et al. 2023

EFSA Supporting Publications

View full text Add to dashboard Cite

Section: Loe1: Motor and Sensory Functions Endpointsmentioning

confidence: 86%

Section: Loe1: Motor and Sensory Functions Endpointsmentioning

confidence: 99%

Section: Loe1: Motor and Sensory Functions Endpointsmentioning

confidence: 99%

See 1 more Smart Citation

Preparatory work for the update of the tolerable upper intake levels for manganese

Halldorsson,

Birgisdottir,

Dudele

et al. 2023

EFSA Supporting Publications

View full text Add to dashboard Cite

“…Pb is present in mineral ores as an impurity and gets into the solution during mining operation (Bao et al, 2016). Manganese is abundant and distributed on the earth's crust in association with ores of iron (Muthaiah et al, 2016). VF3 shows moderate loading on BOD, DO, pH, and negative loading on Fe indicating organic matter influence on the water quality at the studied sites.…”

Section: Factor Analysismentioning

confidence: 95%

Source identification and evaluation of surface water quality using factor and discriminant analysis

Koki¹,

Lawal²,

Taqui³

2019

Bayero J. Pure App. Sci.

View full text Add to dashboard Cite

This study utilizes factor and discriminant analysis to identify the parameter source and evaluate the quality of water from ex-mining ponds and lakes in Selangor. Factor analysis (FA) which explain 83.77% of the surface water quality variation shows that As and Cd that mostly originated from mining activity, and pH are the parameters responsible for the major variation in the surface water quality and were strongly associated with varimax factor 1 (VF1), while Pb, Mn and DO were associated with varimax factor 2 (VF2). The Discriminant analysis (DA) reveals that As, Cd, Mn, Fe and pH are the parameters that significantly differentiate ex-mining ponds from the lake (p < 0.05 and Fratio >> 1), and supported by the correlation study. The elevated metal concentrations in ex-mining ponds compared to lakes were plausibly associated with the past mining operation, thereby indicating heavy metal dominance in ex-mining ponds. DO and BOD are associated with the anthropogenic input from residential sources. Findings of this study therefore show the need and usefulness of multivariate statistical analysis to get information on the quality status of surface water.

show abstract

“…However, oral administration of 30 to 300 μM Cd in adult CBA/CaJ mice for 11 weeks presented normal ABR thresholds (153). Rats exposed to 10 mg Manganese chloride (MnCl 2) /liter water for 90 days showed no significant threshold shifts of DOPAE, CAP, and ABR; while rats exposed to noise simultaneously presented threshold shifts (154). Mice treated with 1.0 mg/kg mercuric sulfide per day through gastric gavage for 7 consecutive days demonstrated in an elevation of ABR threshold and prolongation of interwave latencies I-V (155).…”

Section: Heavy Metalsmentioning

confidence: 99%

Experimental animal models of drug-induced sensorineural hearing loss: a narrative review

Lin¹,

Luo²,

Tan

et al. 2021

Ann Transl Med

View full text Add to dashboard Cite

This narrative review describes experimental animal models of sensorineural hearing loss (SNHL) caused by ototoxic agents.Background: SNHL primarily results from damage to the sensory organ within the inner ear or the vestibulocochlear nerve (cranial nerve VIII). The main etiology of SNHL includes genetic diseases, presbycusis, ototoxic agents, infection, and noise exposure. Animal models with functional and anatomic damage to the sensory organ within the inner ear or the vestibulocochlear nerve mimicking the damage seen in humans are employed to explore the mechanism and potential treatment of SNHL. These animal models of SNHL are commonly established using ototoxic agents.Methods: A literature search of PubMed, Embase, and Web of Science was performed for research articles on hearing loss and ototoxic agents in animal models of hearing loss.Conclusions: Common ototoxic medications such as aminoglycoside antibiotics (AABs) and platinum antitumor drugs are extensively used to induce SNHL in experimental animals. The effect of ototoxic agents in vivo is influenced by the chemical mechanisms of the ototoxic agents, the species of animal, routes of administration of the ototoxic agents, and the dosage of ototoxic agents. Animal models of drug-induced SNHL contribute to understanding the hearing mechanism and reveal the function of different parts of the auditory system in humans.

show abstract

Effect of manganese and manganese plus noise on auditory function and cochlear structures

Cited by 8 publications

References 51 publications

Preparatory work for the update of the tolerable upper intake levels for manganese

Preparatory work for the update of the tolerable upper intake levels for manganese

Source identification and evaluation of surface water quality using factor and discriminant analysis

Experimental animal models of drug-induced sensorineural hearing loss: a narrative review

Contact Info

Product

Resources

About