Effect of male age on the outcome of in vitro fertilization: oocyte donation as a model

Gu, Longjie; Zhang, Hanwang; Yin, Lei; Bu, Zhiqin; Zhu, Guijin

doi:10.1007/s10815-012-9719-9

Cited by 22 publications

(18 citation statements)

References 15 publications

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“…For the comparisons of interrater reliability, the kappa coefficient was 0.86 during the abstract review (95% confidence interval [CI] 0.75-0.97) and 0.92 in the full-text stage (95% CI, 0.76-1.0). Finally, of 425 initial references, twelve manuscripts encompassing 12,538 oocyte donation cases were included in the review (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). Table 1 summarizes the characteristics of the selected studies.…”

Section: Resultsmentioning

confidence: 99%

Effect of paternal age on reproductive outcomes in oocyte donation model: a systematic review

Sagi‐Dain

Sagi

Dirnfeld

2015

Fertility and Sterility

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The available evidence suggests that advancing paternal age is not associated with adverse oocyte donation outcomes, including pregnancy and live-birth rates. However, the suboptimal quality of the available evidence necessitates high-quality, well-adjusted prospective trials that are also aimed at evaluating additional outcomes such as congenital anomalies and various specific long-term disorders.

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Section: Resultsmentioning

confidence: 99%

Effect of paternal age on reproductive outcomes in oocyte donation model: a systematic review

Sagi‐Dain

Sagi

Dirnfeld

2015

Fertility and Sterility

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“…De la Rochebrochard reported that paternal age had a detrimental effect on pregnancy rates in conventional in vitro fertilization (IVF) cycles in cases of paternal and maternal ages >40 y and >35 y, respectively [ 4 ]. However, discrepancies exist when considering oocyte-donation cycles; while some studies indicated a negative influence on embryo quality, implantation rate and live birth rate [ 5 – 8 ], others suggested no effects on the rates of pregnancy, miscarriage and live births [ 9 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Paternal Age on Reproductive Outcomes of In Vitro Fertilization

Kang

Zheng

et al. 2015

PLoS ONE

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Although the adverse effects of maternal aging on reproductive outcomes have been investigated widely, there is no consensus on the impact of paternal age. Therefore, we investigated the effect of paternal age on reproductive outcomes in a retrospective analysis of 9,991 in vitro fertilization (IVF) cycles performed at the Reproductive Medicine Center of the Third Affiliated Hospital of Guangzhou Medical University (China) between January 2007 and October 2013. Samples were grouped according to maternal age [<30 (3,327 cycles), 30–34 (4,587 cycles), and 35–38 (2,077 cycles)] and then subgrouped according to paternal age (<30, 30–32, 33–35, 36–38, 39–41, and ≥42). The groups did not differ in terms of fertilization rate, numbers of viable and high-quality embryos and miscarriage rate when controlling maternal age (P >0.05). Chi-squared analysis revealed that there were no differences in implantation and pregnancy rates among the different paternal age groups when maternal age was <30 and 35–38 years (P >0.05). However, implantation and pregnancy rates decreased with paternal age in the 31–34 y maternal age group (P <0.05). Our study indicates that paternal age has no impact on fertilization rate, embryo quality at the cleavage stage and miscarriage rate. For the 30–34 y maternal age group, the implantation rate decreased with increased paternal age, with the pregnancy rate in this group being significantly higher in the paternal <30 y and 30–32 y age groups, compared with those in the 36–38 y and 39–41 y groups.

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“…The results of this study are in line with the results of studies. 23,[32][33][34][35] A study by Wu et al, showed that there was no difference between the amount of pregnancy and implantation among different male age groups 35 while De la Rochbrochardet al, reported that the age of parents (fathers over 40 years old and mothers over the age of 35) significantly affects fertility in IVF. 29 In this study, there was no significant relationship between sperm motility and IVF.…”

Section: Discussionmentioning

confidence: 99%

“…23 Some studies over the effect of age have shown significant reductions in fertility, live birth, embryo quality and implantation, 24-,30 but others have suggested that age does not affect fertility, abortion and live birth. [31][32][33][34][35] According to Atkinson et al, concentration and sperm motility do not affect the fertility and delivery efficacy in IVF and IUI 36 , but another study suggests that very low sperm motility reduces fertility rates in IVF and ICSI. 37 A number of studies have also shown that leukocytospermia has a negative effect on the efficiency of IVF and ICSI, [38][39][40][41][42][43][44] but some studies have also shown that leukocytospermia has no effect on the incidence of pregnancy and fertility after IVF and ICSI.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Semen Parameters on the Outcome of Induced in Vitro Fertilization (Ivf) in Infertile Couples

Alemi

Omrani

Tarhani

et al. 2019

Int J Life Sci Pharm Res

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Infertility is one of the most important crises in the lifestyle, leading to many problems, for couples. Infertility may be associated with many factors. The aim of this study is to determine the effect of semen parameters on the outcome of Induced in-Vitro Fertilization in infertile women. This study was performed as a retrospective cohort study using infertile couple's data that was provided by IVF in Hamadan University of Medical Sciences Endometrial and Endometriosis Research Center in 2016. Couples who had a normal semen parameter were compared with couples who had an abnormal semen parameter in terms of the outcome of the intervention, which included the positive increase of the β-HCG titer in two time measurements.The total number of subjects studied was 289, with mean age 30.49 years. The percentage of positive β-HCG (31.21%), incidence of fertilization (30.54%) and pregnancy (29.86%). The frequency of abnormal semen parameters based on WHO criteria in term of mobility was 53.98%, sperm number 32.22%, volume 4.45% agglutination 4.53% and leukocytospermia 12% respectively. There were a significant relationship between morphology>20% (p=0.022) and normal sperm adhesion (p=0.041) with pregnancy incidence. The viscosity and morphology of sperm, are two semen parameters that effects on the success rate of fertility Induced in-Vitro Fertilization method.

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Effect of male age on the outcome of in vitro fertilization: oocyte donation as a model

Cited by 22 publications

References 15 publications

Effect of paternal age on reproductive outcomes in oocyte donation model: a systematic review

Effect of paternal age on reproductive outcomes in oocyte donation model: a systematic review

Effect of Paternal Age on Reproductive Outcomes of In Vitro Fertilization

The Effect of Semen Parameters on the Outcome of Induced in Vitro Fertilization (Ivf) in Infertile Couples

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