Effect of lycopene on the blood-spinal cord barrier after spinal cord injury in mice

Zhang, Qian; Wang, Jianbo; Gu, Zheng-Song; Zhang, Qing; Hong, Zheng

doi:10.5582/bst.2016.01062

Cited by 13 publications

(6 citation statements)

References 29 publications

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“…Functions of the BSCB rely on an intricate network of tight junction proteins, including ZO-1 and claudin-5 (Kumar et al, 2017). Following SCI, we report decreased expression of both ZO-1 and claudin-5, consistent with previous reports (Zhang et al, 2016;Zhou et al, 2017;Kumar et al, 2018). Interestingly, LY344864 treatment attenuated these decreases by 7 days post-SCI.…”

Section: Discussionsupporting

confidence: 91%

5-hydroxytryptamine 1F Receptor Agonist Induces Mitochondrial Biogenesis and Promotes Recovery from Spinal Cord Injury

Simmons

Scholpa

Cleveland

et al. 2019

J Pharmacol Exp Ther

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Spinal cord injury (SCI) is characterized by vascular disruption leading to ischemia, decreased oxygen delivery, and loss of mitochondrial homeostasis. This mitochondrial dysfunction results in loss of cellular functions, calcium overload, and oxidative stress. Pharmacological induction of mitochondrial biogenesis (MB) may be an effective approach to treat SCI. LY344864, a 5-hydroxytryptamine 1F (5-HT 1F ) receptor agonist, is a potent inducer of MB in multiple organ systems. To assess the efficacy of LY344864-induced MB on recovery post-SCI, female mice were subjected to moderate force-controlled impactor-induced contusion SCI followed by daily LY344864 administration for 21 days. Decreased mitochondrial DNA and protein content was present in the injury site 3 days post-SCI. LY344864 treatment beginning 1 h after injury attenuated these decreases, indicating MB. Additionally, injured mice treated with LY344864 displayed decreased Evan's Blue dye accumulation in the spinal cord compared with vehicle-treated mice 7 days after injury, suggesting restoration of vascular integrity. LY344864 also increased locomotor capability, with treated mice reaching a Basso-Mouse Scale score of 3.4 by 21 days, whereas vehicle-treated mice exhibited a score of 1.9. Importantly, knockout of the 5-HT 1F receptor blocked LY344864-induced recovery. Remarkably, a similar degree of locomotor restoration was observed when treatment initiation was delayed until 8 h after injury. Furthermore, cross-sectional analysis of the spinal cord 21 days after injury revealed decreased lesion volume with delayed LY344864 treatment initiation, emphasizing the potential clinical applicability of this therapeutic approach. These data provide evidence that induction of MB via 5-HT 1F receptor agonism may be a promising strategy for the treatment of SCI. SIGNIFICANCE STATEMENTTreatment with LY344864 induces mitochondrial biogenesis in both the naive and injured mouse spinal cord. In addition, treatment with LY344864 beginning after impactor-induced contusion spinal cord injury improves mitochondrial homeostasis, blood-spinal cord barrier integrity, and locomotor function within 7 days. Importantly, similar locomotor results are observed whether treatment is initiated at 1 h after injury or 8 h after injury. These data indicate the potential for pharmacological induction of mitochondrial biogenesis through a 5hydroxytryptamine 1F agonist as a novel therapeutic approach for spinal cord injury.

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Section: Discussionsupporting

confidence: 91%

5-hydroxytryptamine 1F Receptor Agonist Induces Mitochondrial Biogenesis and Promotes Recovery from Spinal Cord Injury

Simmons

Scholpa

Cleveland

et al. 2019

J Pharmacol Exp Ther

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“…NF-κB signaling pathway has been shown to participate in mediating SCI pathophysiology, subsequently playing a pivotal role in repairing SCI. Inhibition of NF-κB by different drugs potentially alleviates SCI ( Zhang et al, 2014 , 2016 ; Ni et al, 2015 ). In view of this, inhibition of NF-κB could be a potential target for SCI improvement.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of NF-κB Signaling Pathway by Resveratrol Improves Spinal Cord Injury

Botchway

Zhang

et al. 2018

Front. Neurosci.

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Spinal cord injury (SCI) can have a significant impact on an individual’s life. Herein, we discuss how resveratrol improves SCI by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. Evidences show resveratrol suppresses NF-κB signaling pathway to exert its beneficial effects on various diseases. NF-κB signaling pathway plays a significant role in the pathophysiological mechanisms of SCI including increase in inflammation, augmentation of damage caused by free radicals and lipid peroxidation as well as facilitation of apoptosis and axonal demyelination. We also discuss mechanisms between resveratrol and NF-κB signaling pathway in the wake of SCI, which can be potential targets for resveratrol to treat SCI.

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“…It was demonstrated that lycopene treatment in SCI rats significantly improved oxidative stress, by reversing SOD, GPX, and MDA alterations [65]. Lycopene reduced lipid peroxidation in murine models [65,66] and NF-κB activation in a mouse model of SCI [66]. Similar inhibition of NF-κB has been reported for beta-carotene in a rat model of SCI [67].…”

Section: Dietary Antioxidants In Spinal Cord Injurymentioning

confidence: 52%

Hormetic Effects of Bioactive Compounds from Foods, Beverages, and Food Dressing: The Potential Role in Spinal Cord Injury

Fedullo

Ciccotti²,

Giannotta³

et al. 2021

Oxidative Medicine and Cellular Longevity

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Spinal cord injury (SCI) is a damage or trauma to the spinal cord resulting in a total or partial loss of motor and sensory function. SCI is characterized by a disequilibrium between the production of reactive oxygen species and the levels of antioxidant defences, causing oxidative stress and neuroinflammation. This review is aimed at highlighting the hormetic effects of some compounds from foods, beverages, and food dressing that are able to reduce oxidative stress in patients with SCI. Although curcumin, ginseng, and green tea have been proposed for SCI management, low levels of antioxidant vitamins have been reported in individuals with SCI. Mediterranean diet includes food rich in vitamins and antioxidants. Moreover, food dressing, including spices, herbs, and extra virgin olive oil (EVOO), contains multiple components with hormetic effects. The latter involves the activation of the nuclear factor erythroid-derived 2, consequently increasing the antioxidant enzymes and decreasing inflammation. Furthermore, EVOO improves the bioavailability of carotenoids and could be a delivery system for bioactive compounds. In conclusion, Mediterranean dressing in addition to plant foods can have an important effect on redox balance in individuals with SCI.

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Effect of lycopene on the blood-spinal cord barrier after spinal cord injury in mice

Cited by 13 publications

References 29 publications

5-hydroxytryptamine 1F Receptor Agonist Induces Mitochondrial Biogenesis and Promotes Recovery from Spinal Cord Injury

5-hydroxytryptamine 1F Receptor Agonist Induces Mitochondrial Biogenesis and Promotes Recovery from Spinal Cord Injury

Inhibition of NF-κB Signaling Pathway by Resveratrol Improves Spinal Cord Injury

Hormetic Effects of Bioactive Compounds from Foods, Beverages, and Food Dressing: The Potential Role in Spinal Cord Injury

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