Effect of luminal pH on the absorption of water, Na+ and Cl− by rat intestine in vivo

Rousseau, B; Sladen, G. E.

doi:10.1016/0005-2736(71)90157-x

Cited by 31 publications

(3 citation statements)

References 6 publications

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“…Therefore, in addition to the previously established gradients of salt, water, and glucose transport, there are also proximaldistal gradients of glucose-stimulated and bicarbonate-stimulated transport and a gradient of sensitivity of the transport systems to low pH. Since the transport capacity of the colon is even less sensitive to lowered pH (Rousseau and Sladen 1971 ) it appears that the latter gradient extends also into the colon.…”

Section: Unin F Ected Intestinementioning

confidence: 88%

Proximal–distal absorptive gradients in the in vivo intestine of normal and infected (Hymenolepis diminuta: Cestoda) rats

Podesta¹,

Mettrick²

1977

Can. J. Physiol. Pharmacol.

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Using a single-pass perfusion technique, H2O, Na+, Cl-, HCO3-, and glucose absorption were studied in the jejunum and proximal and distal ileum of rats either uninfected or infected with a tapeworm parasite (Hymenolepis diminuta). The effect of parasitization, region of the intestine, type of buffer, and concentration of glucose in the perfusion fluids on the transport data were analyzed by univariate and multivariate techniques. Proximal-distal flux gradients were observed for water and all the solute species studied, as well as for glucose- and bicarbonate-stimulated salt and water transport; there was a decreasing sensitivity to low pH proceeding distally. The major regional differences occurred between the proximal and distal ileum, with the fluxes in the jejunum being similar to those in the proximal ileum. Na+, H2O, and glucose transport decreased, while Cl- absorption increased, proceeding distally. The parasites diminished the rates of absorption of glucose, salt, and water, and altered the flux gradients, particularly the Na+ and HCO3- transport gradients. The differences in the gradients between control and infected animals were related to differential sensitivity of the different transport systems in the various regions of the gut to parasitism.

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Section: Unin F Ected Intestinementioning

confidence: 88%

Proximal–distal absorptive gradients in the in vivo intestine of normal and infected (Hymenolepis diminuta: Cestoda) rats

Podesta¹,

Mettrick²

1977

Can. J. Physiol. Pharmacol.

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“…In thc in viva jejunum and ileum, fluid transport is reduced by lowering the pH (McHardy and Parsons 1957;Rousseau and Sladen 1971). Parsons ( 1 97 1 ), however, was unable to demonstrate a significant effect sf low pH on in vitro ileal fluid transport.…”

Section: Normal Rat Intestinementioning

confidence: 97%

Components of Glucose Transport in the Host–Parasite System, Hymenolepis diminuta (Cestoda) and the Rat Intestine

Podesta¹,

Mettrick²

1974

Can. J. Physiol. Pharmacol.

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Glucose and fluid transport by the rat intestine and by the tapeworm Hymenolepis diminuta has been studied in vivo, using closed loops of the entire small intestine. The effect of pH, glucose concentration, and the presence of sodium on solute and solvent absorption has been determined in both host and parasite. The effect of the worms on intestinal absorption by the rat has also been evaluated. Three components of the glucose transport system, namely active transport, diffusion, and solvent drag, were determined by means of a model transport equation.Saturation kinetics for glucose absorption did not occur and the absence of sodium in the luminal fluid, while not affecting glucose absorption, markedly reduced fluid absorption by both the intestine and the worms. Lowering the pH of luminal fluids significantly reduced glucose transport by the intestine but increased absorption of fluid and glucose by H. diminuta. Irrespective of pH, fluid and glucose absorption were significantly reduced in the parasitized intestine.Active transport of glucose by normal or parasitized intestine and by H. diminuta was unaffected by the concentration of glucose in the lumen, or by changes in pH. The solvent drag and diffusion components of glucose transport were reduced by increasing the hydrogen ion concentration in uninfected and parasitized intestines. The solvent drag component of glucose absorption by the tapeworms was increased with increasing hydrogen ion concentration.The results are discussed in terms of the current hypotheses on the mechanism of glucose transport, sodium dependency, and the effect of hydrogen ions on transport mechanisms.

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“…Several effects may be produced. The osmolarity of colonic contents may increase (Pertsiounis, 1970) and, as shown in animal studies, the fall in pH may reduce water absorption (Rousseau and Sladen, 1970) and stimulate propulsion (unpublished data).…”

Section: Laxativesmentioning

confidence: 95%

Pharmacology of colonic muscle.

Bennett¹

1975

Gut

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Effect of luminal pH on the absorption of water, Na+ and Cl− by rat intestine in vivo

Cited by 31 publications

References 6 publications

Proximal–distal absorptive gradients in the in vivo intestine of normal and infected (Hymenolepis diminuta: Cestoda) rats

Proximal–distal absorptive gradients in the in vivo intestine of normal and infected (Hymenolepis diminuta: Cestoda) rats

Components of Glucose Transport in the Host–Parasite System, Hymenolepis diminuta (Cestoda) and the Rat Intestine

Pharmacology of colonic muscle.

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