Effect of &lt;i&gt;Pithecellobium jiringa&lt;/i&gt; as antimicrobial agent

Bakar, Ruzilawati Abu; Ahmad, Imran; Sulaiman, Shaida Fariza

doi:10.3329/bjp.v7i2.10973

Cited by 11 publications

(8 citation statements)

References 8 publications

(3 reference statements)

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“…According to Raut, Shinde, Chanhan, & Karuppayil (2013) that plant terpenoids inhibit morphogenesis, adhesion and formation of biofilms by C. albicans. Minimum inhibitory consentration in previous research showed that the leaves extract of A. jiringa was most active against S. aureus, S. epidermidis and Microsporum gypseum (100 mg/mL) (Bakar, Ahmad, & Sulaiman, 2012). The results of this study with ethanol-water fraction can inhibit P. aeruginosa, S. mutans and C. albicans MIC at 50 mg/mL.…”

Section: Minimum Inhibitory Concentrationssupporting

confidence: 49%

Effectiveness of Leaves Extract Fractions of Archidendron jiringa (Jack) I.C Nielsen Against Microbes

Komala¹,

Wardatun²,

Sari³

2019

Molekul

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Archidendron jiringa(Jack) I.C Nielsen) contains a lot of essential oils, saponins, alkaloids, terpenoids, steroids, tannins, glycosides, and flavonoids. Flavonoid is a secondary metabolite compound in a plant as antimicrobial. This study aims to determine the antimicrobial activity of fractions of ethanol 96%, n-hexan, ethyl acetate, and ethanol-water leaves extractand determine levels of favonoids. A. jiringaleaves extract were tested against Streptococus mutans, Pseudomonas aeruginosa, and Candida albicans. The research using agar disc diffusion technique for antimicrobial activity and colorimetric method to know the total of flavonoid. Chloramphenicol and ketoconazole were used as a reference standard. The result of this study shows fractions of ethanol 96%, n-hexane, ethyl acetate, and ethanol-water A. jiringaleaves extract can inhibit microbial growth of S. mutans, P. aeruginosa, and C. albicans.Total of flavonoids on the extract respectively are 1.13%, 0.494%, 2.337%, and 0.549%. determined with complementary colorimetry to each leaf extract fractionA. jiringawith aluminum chloride method. Absorption spectrum measurement using a spectrophotometer. The higher percent of flavonoids would cause greater bacteriainhibitory zone but only 0.090 for pearson correlation value. Conclusions ethyl acetate leaves extract most effective inhibit microbial growth from the other fractions.

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Section: Minimum Inhibitory Concentrationssupporting

confidence: 49%

Effectiveness of Leaves Extract Fractions of Archidendron jiringa (Jack) I.C Nielsen Against Microbes

Komala¹,

Wardatun²,

Sari³

2019

Molekul

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“…The determination of these doses was based on a preliminary study stating that jengkol leaf extract containing antifungal materials that has a minimum inhibition concentration (MIC) of 100 mg/ ml against C. albicans. 12 In Table 2, the mean value of the optical density (OD) in the control group (untreated group) was 1.23, higher than the groups treated with doses of 100 mg/ ml and 200 mg/ ml generating 0.2 for each, and a dose of 400 mg/ ml deriving 0.21. It means that the number of C. albicans biofilms in the treatment groups was fewer than in the control group (untreated group).…”

Section: Discussionmentioning

confidence: 93%

“…Similarly, an initial research claims that jengkol leaf extract is antifungal against C. albicans cells. 12 Based on phytochemical examination in the laboratory of the Faculty of Pharmacy, Universitas Airlangga, jengkol leaf extract positively contains alkaloids, flavonoids, terpenoids, and polyphenols. Jengkol also contains lectin compounds.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effect of jengkol leaf (Pithecellobium jiringa) extract to inhibit Candida albicans biofilm

Luthfi

Arundina

Hamni

2016

Dent. J. (Majalah Kedokteran Gigi)

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Background: Candida albicans (C. albicans) are dimorphic fungi in oral cavity, considered not only as normal flora, but also as pathogens. C. albicans have an ability to grow biofilm, which has a thick layer of outer skin structure, called as extracellular matrix. Jengkol leaves (Pithecellobium jiringa) contain alkaloids, flavonoids, terpenoids, and lectins, which have an ability as antifungal agent Purpose: This study aimed to analyze the optimum dose of jengkol leaf extract as antibiofilm against C. albicans biofilms. Method: C. albicans were cultured on yeast peptone dextrosa (YPD) media in 96-well microtiter plate flat bottom plates. There were one control group (without treatment) and three treatment groups. The first treatment group was given jengkol leaf extract at a dose of 100 mg/ ml. The second treatment group was given jengkol leaf extract at a dose of 200 mg/ ml. And, the third treatment group was given jengkol leaf extract at a dose of 400 mg/ ml. Semi quantitative method was applied to determine C. albicans biofilmsis using Crystal Violet staining technique. The absorbance of the cells then was calculated using a spectrophotometer with a wavelength of 570 nm. Result: The mean value of optical density in the control group was 1.23. The mean value of optical density in the treatment group with a dose of 100 mg/ ml was 0.2. Meanwhile, the mean value of optical density in the treatment group with a dose of 200 mg/ ml was 0.2, and 0.21 in the treatment group with a dose of 400 mg/ ml. The results also showed that there were significant differences between the control group and all of the treatment groups (p<0.05), but there was no significant difference between the treatment groups (p>0.05). Conclusion: The optimum dose of jengkol leaf extract used as antibiofilm against C. albicans biofilms is 100 mg /ml with an inhibitory percentage of 83.7%.

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“…Methanol extract leaves of A. jiringa active as antibacterial were mostly active for Staphylococcus aureus, S. epidermidis, and Microsporum gypsum. 18 The shoot of A. jiringa has been found to have high polyphenolic contents (>150 g gallic acid equivalents/mg dried plant) and antioxidant activities measured using ferric reducing antioxidant power (FRAP) method, also have high potent to 2,2-diphenyl-1-picrylhydrazyl(DPPH) scavenging activity. 19,20 The beans of this plant are used as food sources in Indonesia and contain djenkolic acid and sulfur.…”

mentioning

confidence: 99%

Antiviral effect of <em>Archidendron pauciflorum</em> leaves extract to hepatitis C virus: An <em>in vitro</em> study in JFH-1 strain

et al. 2018

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Background: Hepatitis C virus (HCV) is a leading cause of chronic liver diseases. Drug resistance to the regimen is also increasing. Hence, there is a need for new anti-HCV agents that are less toxic and more efficacious. The aim of this study is to evaluate the possibility of A. pauciflorum extracts can be a antiviral drug.Methods: Huh-7it cells were infected with the HCV genotype 2a strain JFH-I in the presence of methanol extracts of Archidenron pauciflorum. The methanol extract further partition used n-hexane, ethyl acetate, n-butanol, and water showed in which butanol extracts exerted the strongest IC50 (6.3 g/ml). Further, the butanol fraction was fractionated and yielded into 13 fractions.Results: The methanol extract of the leaves of A. pauciflorum exhibited concentration dependent inhibition against the JFH1 strain of HCV genotype 2a with an IC50 is 72.5 μg/ml. The butanol fraction exhibited the highest anti-HCV activity with an IC50 is 6.3 μg/ml. The butanol fraction was fractionated which yielded 13 fractions. Fractions 5 and 13 exhibited high anti-HCV activities with IC50 is 5.0 μg/ml and 8.5 μg/ml and a time-of-addition study demonstrated that fraction 5 inhibited viral infection at the post-entry step, whereas fraction 13 primarily inhibited the viral entry step.Conclusion: The extract A. pauciflorum can be used as a herbal-based antiviral drug.

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Effect of <i>Pithecellobium jiringa</i> as antimicrobial agent

Cited by 11 publications

References 8 publications

Effectiveness of Leaves Extract Fractions of Archidendron jiringa (Jack) I.C Nielsen Against Microbes

Effectiveness of Leaves Extract Fractions of Archidendron jiringa (Jack) I.C Nielsen Against Microbes

Inhibitory effect of jengkol leaf (Pithecellobium jiringa) extract to inhibit Candida albicans biofilm

Antiviral effect of <em>Archidendron pauciflorum</em> leaves extract to hepatitis C virus: An <em>in vitro</em> study in JFH-1 strain

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