Effect of Low Zinc Intakes on Basal Metabolic Rate, Thyroid Hormones and Protein Utilization in Adult Men

Wada, Leslie; King, Janet C.

doi:10.1093/jn/116.6.1045

Cited by 93 publications

(56 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The available data on thyroid disrupting effects of heavy metals mediated by the interaction with TR are limited. A previous study reported that zinc is an integral part of TR proteins and is crucial for binding the receptors to their target genes [35]. Surks et al [36] reported that the addition of ZnCl 2 , CuCl 2 , CdCl 2 and NiCl 2 resulted in a concentration-dependent inhibition of the binding of T 3 to TR, and the concentration of 8 × 10 −7 mol/L ZnCl 2 resulted in a significant decrease in specific binding of [ 125 I] T 3 by nuclear receptors.…”

Section: Discussionmentioning

confidence: 99%

Thyroid hormone disrupting activities of sediment from the Guanting Reservoir, Beijing, China

Ren

et al. 2014

Journal of Hazardous Materials

View full text Add to dashboard Cite

h i g h l i g h t s• Yeast bioassays were used to evaluate the TR disrupting activities of the sediments.• The organic extracts showed TR antagonistic activities.• The elutriates also significantly antagonized the TR.• The causes of toxicity in the elutriates appear to be partly related to the heavy metals. a r t i c l e i n f o a b s t r a c tIn the present study, yeast bioassays were used to evaluate and characterize the thyroid receptor (TR) disrupting activities of the organic extracts and elutriates of the sediments from the Guanting Reservoir, Beijing, China. An accelerated solvent extraction was used to separate the organic extracts, which were subjected to a yeast bioassay. The organic extracts could affect thyroid hormone signaling by decreasing the binding of the thyroid hormone. The TR antagonistic activity equivalents (TEQ bio ) referring to amiodarone hydrochloride were calculated and the observed TEQ bio-organic extracts ranged from 25.4 ± 3.7 to 176.9 ± 18.0 g/g. Elutriate toxicity tests using the modified yeast bioassay revealed that the elutriates also significantly antagonized the TR, with the TEQ bio-elutriates ranging from N.D. to 7.8 ± 0.8 g/L. To characterize the toxic compounds, elutriates were extracted by using a C18 cartridge or treated with ethylenediaminetetraacetic acid (EDTA, 30 mg/L). The results suggested that the addition of EDTA eliminated over 74.3% of the total effects, and the chemical analysis revealed that heavy metals, some of which exhibited TR disrupting potency, for example Zn and Cd, were detectable with higher concentrations in the elutriates. Thus, the cause(s) of toxicity in the elutriate appear to be partly related to the heavy metals.

show abstract

Section: Discussionmentioning

confidence: 99%

Thyroid hormone disrupting activities of sediment from the Guanting Reservoir, Beijing, China

Ren

et al. 2014

Journal of Hazardous Materials

View full text Add to dashboard Cite

show abstract

“…Sympathetic nervous system activity, daily energy intake, physical activity and thyroid hormones are possible modulators of the changes in BMR (Morgan & York, 1983;Fukagawa et al, 1990;Visser et al, 1995;Klausen et al, 1997). Animal (Morley et al, 1980;Fujimoto et al, 1986;Lukaski et al, 1992;Kralik et al, 1996) and human (Wada & King, 1986;Oliver et al, 1987) studies have shown that zinc deficiency is associated with decreases in circulating thyroid hormone levels, in the ratio T3/T4 and in BMR. It is postulated that iodothyronine deiodinase expression is zinc sensitive and that the production of T3 is therefore reduced in zinc deficiency (Lukaski et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects: the ZENITH study

Meunier

Beattie²,

Ciarapica

et al. 2005

Eur J Clin Nutr

View full text Add to dashboard Cite

Objective: This paper describes baseline data on basal metabolic rate (BMR), thyroid hormone levels and body composition of middle-aged and older people participating in the ZENITH project and the correlation of thyroid hormone levels with zinc status. Design: A multicentre prospective intervention study employing a randomised double blind design. Setting: Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy). Interventions: BMR has been measured on a subsample of 70 middle-aged volunteers (35 men and 35 women recruited in ClermontFerrand, France, aged 55-70 y) and 108 older volunteers (56 men and 52 women recruited in Rome, Italy, aged 70-85 y). Thyroid hormone levels were evaluated in the entire group of ZENITH volunteers (n ¼ 387). BMR was measured by indirect calorimetry. Fatfree mass (FFM) was derived by four skinfold thicknesses using Durnin and Womersley's equations. Concentrations of thyroid hormones (total T3 and T4) were measured using a competitive immunoassay with an enhanced chemiluminescence end point. Results: Italian older volunteers had a significantly lower FFM than middle-aged French volunteers (À7% Po0.01). A negative correlation between BMR and age (men, r ¼ À0.64; women, r ¼ À0.62; both Po0.0001) was observed: BMR was significantly (Po0.000001) lower in Italian elderly volunteers (4.0370.46 kJ/min and 3.2970.42 kJ/min for men and women, respectively) than in middle-aged French volunteers (4.8470.45 kJ/min and 3.8770.38 kJ/min for men and women, respectively), even after adjustment for FFM (À12%). No correlation has been observed between BMR and thyroid hormones both in French and Italian subjects. Total T4 (TT4) concentrations were lowest in middle-aged population (À10%, Po0.0001). A moderate negative correlation has been found with TT4 and red blood cell zinc (r ¼ À0.12, Po0.02, slope À0.026). Conclusions:The results confirm an age-related decline in BMR not entirely explained by body composition or thyroid hormones differences.

show abstract

“…Zinc is a known fundamental component of the endogenous enzymatic antioxidant system and plays an essential role in cell membrane integrity and functions in many aspects of cellular metabolism [21,22]. Zinc is also required for the activity of the enzyme 1,5'-deiodinase, which converts biologically T4 to T3 [23,24]. The fact that Zinc levels are lower in hypothyroidism Baltaci, et al (1999) [25] points out to a relationship between Zinc and thyroid gland.…”

Section: Introductionmentioning

confidence: 99%

Effect of Iron, Zinc, Vitamin E and Vitamin C Supplementation on Thyroid Hormones in Rats with Hypothyroidism

Rabeh¹,

El-Ghandour²

2016

IJNFS

View full text Add to dashboard Cite

Abstract:The aim of the study was to investigate the effect of Iron, Zinc, Vitamin C (Vit.C) and Vitamin E (Vit.E) supplementation on thyroid hormones in rats with hypothyroidism. Thirty six rats were divided into two main groups, the first main group (6 rats) was fed on basal diet only. The second main group (30 rat) were injected with 10 mg/kg/day Propylthiouracil (PTU) to induce hypothyroidism, was divided into 5 subgroups: including control positive group that fed on basal diet, and the other subgroups were fed on basal diet supplemented with 40 mg ferric sulphate/kg diet, 200 mg zinc carbonate /kg diet, 250 mg α-tocohperol acetate/kg/B.W. and 250 mg ascorbic acid/kg/B.W. respectively. Blood samples were collected from each rat and were centrifuged to obtain serum. PTU exposed rats showed hypothyroidism with significant (P<0.05) decline in serum FT3 and FT4 levels together with significant (P<0.05) increase in serum TSH level. The supplementation with Iron, Zinc, Vit.E or Vit.C significantly (P<0.05) increased the level of thyroid hormones (FT4 and FT3) and glutathione peroxidase, moreover, the level of TSH was significantly (P<0.05) decreased, compared with control positive group, might be due to their antioxidant properties. Significant improvement in lipid profile as well as liver and kidney functions were observed. It could be suggested that Vitamin C, Vitamin E, Zinc and Iron could be used as a suitable supplementation therapy for hypothyroidism patients.

show abstract

Effect of Low Zinc Intakes on Basal Metabolic Rate, Thyroid Hormones and Protein Utilization in Adult Men

Cited by 93 publications

References 21 publications

Thyroid hormone disrupting activities of sediment from the Guanting Reservoir, Beijing, China

Thyroid hormone disrupting activities of sediment from the Guanting Reservoir, Beijing, China

Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects: the ZENITH study

Effect of Iron, Zinc, Vitamin E and Vitamin C Supplementation on Thyroid Hormones in Rats with Hypothyroidism

Contact Info

Product

Resources

About