Effect of low power microwave on the mouse genome: A direct DNA analysis

Sarkar, Sukanya; Ali, Sher; Behari, J.

doi:10.1016/0165-1218(94)90066-3

Cited by 106 publications

(45 citation statements)

References 19 publications

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“…However, MWs can cause disturbances of the sensitive equilibrium between prooxidant and anti-oxidant factors within cells and therefore cause oxidative stress-related cell injury and apoptosis [4,[8][9][10][11].…”

Section: Microwaves and Oxidative Stress In Testicular Tissuementioning

confidence: 99%

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The Effects of Melatonin on Oxidative Stress Parameters and DNA Fragmentation in Testicular Tissue of Rats Exposed to Microwave Radiation

Djordjević¹,

Kocić²,

Stoimenov³

et al. 2015

Adv Clin Exp Med

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Background. Microwaves from mobile phones are one of the environmental toxicants that are capable of compromising male fertility by inducing oxidative stress and apoptosis in the testes. Melatonin is a lipophilic tryptophan indole amine and a potent antioxidant. Objectives. The aim of the study was to evaluate the effect of melatonin treatment on oxidative stress parameters and DNA fragmentation in the testicular tissue of rats exposed to microwave radiation (4 h/day). Material and Methods. Adult Wistar rats were divided in 4 groups: I -treated with saline; II -treated with melatonin; III -exposed to microwaves; IV -exposed to microwaves and treated with melatonin. The melatonin (2 mg/kg ip) was administered daily. The animals were sacrificed after 20, 40 and 60 days. Results. Melatonin treatment prevented previously registered increases in malondialdehyde after only 20 days. Furthermore, it reversed the effects of microwave exposure on xanthine oxidase (after 40 days) and acid-DNase activity (after 20 days). However, neither protein carbonyl content nor catalase and alkaline Dnase activity were changed due to melatonin treatment. Conclusions. Melatonin exerts potent antioxidant effects in the testes of rats exposed to microwaves by decreasing the intensity of oxidative stress; it also reduces DNA fragmentation (Adv Clin Exp Med 2015, 24, 3, 429-436).

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Section: Microwaves and Oxidative Stress In Testicular Tissuementioning

confidence: 99%

“…Increased production of free radicals during exposure to microwave radiation is usually associated with DNA damage in tissues [9,10]. In order to limit the effects of oxidative stress, cells can respond by committing suicide, and in this case the ROS produced by mitochondria can act as a trigger for apoptotic cell death through the activation of caspases [11].…”

mentioning

confidence: 99%

The Effects of Melatonin on Oxidative Stress Parameters and DNA Fragmentation in Testicular Tissue of Rats Exposed to Microwave Radiation

Djordjević¹,

Kocić²,

Stoimenov³

et al. 2015

Adv Clin Exp Med

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“…A direct genotoxic action is unlikely because of the low energy of microwave photons which are unable to cause strand breaks in DNA. However, despite this general conviction that microwaves are not sufficiently energetic to be able to directly damage DNA, there is considerable evidence indicating that microwaves can be directly and indirectly clastogenic, with a significant increase in chromosome damage (Sagripanti and Swicord, 1986;Garaj-Vrhovac et al, 1991, 1992Maes et al 1993;Haidler et al, 1994;Sarkar et al, 1994;Singh 1995, 1996;Timchenko and Ianchevskaia, 1995;Balode, 1996;Verschaeve et al, 1994;Vijayalaxmi et al, 1997;Phillips et al, 1998;Tice et al, 1999). In addition, cell phone radiation can alter protooncogene activity (Ivaschuk et al, 1997;Goswami et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Cytogenetic analysis of the effects of 2.5 and 10.5 GHz microwaves on human lymphocytes

2004

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The biological effects of microwaves on living organisms remain highly controversial. Although some reports have suggested that microwaves may be directly or indirectly genotoxic, a direct action is unlikely because the low energy of microwave photons makes them unable to cause single-strand breaks in DNA. In this work, we examined the possible clastogenic properties of microwaves (2.5 and 10.5 GHz) on blood lymphocytes in vitro by monitoring the frequency of chromosomal aberrations. We also investigated whether blood cells showed increased radiosensitivity or radioresistance when pretreated with the microwaves and then irradiated with gamma radiation. There was no significant difference in the frequency of chromosomal aberrations between cells which had or had not been treated with microwaves. Control cells had a mean frequency of 0.013 aberrations per cell compared to 0.010 and 0.011 aberrations per cell in the microwave-exposed samples. Nor was there any alteration in the radiosensitivity of cells pretreated with microwaves. Gamma irradiated cells showed a mean frequency of 0.279 aberrations per cell compared to 0.343 and 0.310 aberrations per cell in samples pretreated with microwaves. However, cell mortality increased markedly after exposure to microwaves. The results suggest that microwaves do not interact directly or indirectly with chromosomes, although they may target other cell structures, such as cell membranes.

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“…Though, epidemiological studies suggest the existence of weak links between exposure of EMF and human diseases [7] at molecular [8] and cellular levels [9], on immune processes [10], in DNA [11], on the nervous [12], cardiac [13], endocrine [14] reproductive [15] and neurobehavioral effects [16].…”

Section: Introductionmentioning

confidence: 99%

Induction of Oxidative Stress in Male Rats Subchronically Exposed to Electromagnetic Fields at Non-Thermal Intensities

Achudume¹,

Onibere²,

Aina³

et al. 2010

JEMAA

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Effect of low power microwave on the mouse genome: A direct DNA analysis

Cited by 106 publications

References 19 publications

The Effects of Melatonin on Oxidative Stress Parameters and DNA Fragmentation in Testicular Tissue of Rats Exposed to Microwave Radiation

The Effects of Melatonin on Oxidative Stress Parameters and DNA Fragmentation in Testicular Tissue of Rats Exposed to Microwave Radiation

Cytogenetic analysis of the effects of 2.5 and 10.5 GHz microwaves on human lymphocytes

Induction of Oxidative Stress in Male Rats Subchronically Exposed to Electromagnetic Fields at Non-Thermal Intensities

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