Effect of low-dose X-ray radiation on adaptive response in gastric cancer cell

Wang, Shukai; Ji, Gang; Yu, Hongsheng; Liu, Xiangping; Xu, Chang

doi:10.1007/s10330-012-1134-2

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…Scrutiny of reports has demonstrated the protection against radiations in human malignant melanoma, epidermoid laryngeal carcinoma, ovarian carcinoma, myeloma, fibrosarcoma, glioblastoma, and epithelial carcinoma [33–37], but only a very few reports are available in chemically induced adaptive response [38–40]. Contrary to these results, Park et al [41] using mouse papilloma and lymphoma, Schaffer et al [42] using human bladder carcinoma, Jiang et al [43] using two leukemia cell lines (erythroleukemia, promyelocytic leukemia) and two solid tumor cell lines (lung carcinoma and glioma), Sowa et al [44] using colon carcinoma, and Wang et al [45] using gastric cancer cells have clearly showed the absence of the adaptive response. Thus, there are conflicting reports on the adaptive response in cancerous cell.…”

Section: Introductionmentioning

confidence: 99%

Inducible Protective Processes in Animal Systems XIII: Comparative Analysis of Induction of Adaptive Response by EMS and MMS in Ehrlich Ascites Carcinoma Cells

Mahadimane

Vasudev

2014

Scientifica

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In order to investigate the presence of adaptive response in cancerous cells, two monofunctional alkylating agents, namely, ethyl methanesulfonate (EMS) and methyl methanesulfonate (MMS), were employed to treat Ehrlich ascites carcinoma (EAC) cells in vivo. Conditioning dose of 80 mg/kg body weight of EMS or 50 mg/kg body weight of MMS and challenging dose of 240 mg/kg body weight of EMS or 150 mg/kg body weight of MMS were selected by pilot toxicity studies. Conditioned EAC cells when challenged after 8 h time lag resulted in significant reduction in chromosomal aberrations compared to challenging dose of respective agents. As has been proved in earlier studies with normal organisms, even in cancerous cells (EAC), there is presence of adaptive response to methylating and ethylating agents. Furthermore, it is also interesting to note in the present studies that the methylating agent, MMS, is a stronger inducer of the adaptive response than the ethylating agent, EMS.

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Section: Introductionmentioning

confidence: 99%

Inducible Protective Processes in Animal Systems XIII: Comparative Analysis of Induction of Adaptive Response by EMS and MMS in Ehrlich Ascites Carcinoma Cells

Mahadimane

Vasudev

2014

Scientifica

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Modulation of MMP-2 and TIMP-2 by low dose radiation in mice bearing S180 sarcoma

贾祥敏

于洪升

2016

Oncology and Translational Medicine

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ObjectiveTo investigate the inhibition of low dose radiation (LDR) on S180 sarcomas and its modulation of MMP-2 and TIMP-2 in mice.MethodsS180 subcutaneously implanted tumor model mice were randomly divided into two groups: control (N) and low dose radiation (LDR) groups. N mice were sacrificed after 12 h, whereas LDR mice were sacrificed after 12 (LDR-12 h), 24 (LDR-24 h), 48 (LDR-48 h), and 72 (LDR-72 h) h. Thereafter, we measured the tumor volumes. Histopathology was performed, and P-V immunohistochemistry was applied to assess MMP-2 and TIMP-2 expression.ResultsCompared with the control group, the tumor growth was significantly inhibited in the LDR groups (P < 0.05). MMP-2 expression was considerably reduced in LDR-24h (P < 0.05) and LDR-48h (P < 0.05), whereas the change of TIMP-2 was not obvious in the LDR groups (P > 0.05) in contrast to that of the control group.ConclusionLDR can effectively suppress the growth of S180 implanted tumors by reducing MMP-2, which is associated with invasion and metastasis.

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DNA double-strand break repair and adaptive responses of low-dose radiation in normal and tumor lung cell lines

Farhadi

Bahreyni-Toossi²,

Zafari-Ghadim³

et al. 2022

Mutation Research/Genetic Toxicology and Environmental Mutagene

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Effect of low-dose X-ray radiation on adaptive response in gastric cancer cell

Cited by 4 publications

References 13 publications

Inducible Protective Processes in Animal Systems XIII: Comparative Analysis of Induction of Adaptive Response by EMS and MMS in Ehrlich Ascites Carcinoma Cells

Inducible Protective Processes in Animal Systems XIII: Comparative Analysis of Induction of Adaptive Response by EMS and MMS in Ehrlich Ascites Carcinoma Cells

Modulation of MMP-2 and TIMP-2 by low dose radiation in mice bearing S180 sarcoma

DNA double-strand break repair and adaptive responses of low-dose radiation in normal and tumor lung cell lines

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