Effect of Low Dose Oral Vitamin-D and Calcium Replacement in HIV Patients

S, Das; Bopitya, Shyamalie; Chowdhury, Ananya R.; Das, Archik; Taha, Huda

doi:10.2174/1574891x11666160201122236

Cited by 4 publications

(3 citation statements)

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“…Conesa-Botella et al (15) showed that vitamin D deficiency was common before highly active antiretroviral therapy (HAART) and after 12 months on HAART, vitamin D level had a significant decrease. After a 12 months follow-up, replacement of low dose once daily oral vitamin D with calcium in treatment-experienced HIV patients with vitamin D deficiency can elevate the vitamin D level (23).…”

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confidence: 99%

Serum Levels of Vitamin D, Magnesium, Calcium, Iron, and TIBC in HIV-Infected Patients

Janbakhsh¹,

Mansouri²,

Vaziri³

et al. 2018

J Kermanshah Univ Med Sci

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Background: Vitamin D insufficiency and HIV infection are both risk factors for chronic disorders. Several studies on small groups of male HIV-infected patients have reported alterations of calcium and bone metabolisms. This study aimed to evaluate serum levels of vitamin D, magnesium, calcium, iron, and TIBC in HIV-infected patients compared with controls in the west of Iran. Methods: In a case-control study approved by the Ethics Committee of Kermanshah University of Medical Sciences, 98 prisoners with HIV and 98 controls were selected in 2016. Age, sex, vitamin D, calcium, magnesium, iron and total iron binding capacity (TIBC) were checked for all participants in both groups. Also, CD4 was checked in all HIV-infected patients. Results: The mean age ± SD (range) of HIV-infected and control groups was 40.11 ± 7.73 (21.68) and 45.59 ± 18.61 (18.85) years, respectively. Vitamin D, calcium, iron, and TIBC levels were significantly different in these two groups (P < 0.05). Vitamin D deficiency was higher in the HIV-infected group than that in the control group. Furthermore, calcium, iron and TIBC levels were higher in the HIV-infected group compared with those in the control group. Conclusions: This study showed that calcium, iron and TIBC levels were significantly higher in HIV-infected patients compared with those in the control group. Moreover, vitamin D insufficiency and deficiency were higher in HIV-infected patients. The patients with CD4 < 200 cells/mm 3 had less calcium and iron levels compared with 200-500 and > 500 cells/mm 3 .

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confidence: 99%

Serum Levels of Vitamin D, Magnesium, Calcium, Iron, and TIBC in HIV-Infected Patients

Janbakhsh¹,

Mansouri²,

Vaziri³

et al. 2018

J Kermanshah Univ Med Sci

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“…Yet, it is important that this does not allow identification of causal relations, as low levels of 25(OH) D can be seen as both, cause or consequence of sHPT, since high PTH levels can decrease 25(OH)D concentrations by increasing 1-hydroxylation [5]. Nevertheless, it has been well-established that vitamin D is important in maintaining calcium homeostasis and vitamin D supplementation has been demonstrated to lower PTH levels [23][24][25]. Interestingly, in our cohort there was no significant difference in the prevalence of sHPT in patients with or without vitamin D supplementation (13.6 % vs. 16.7 %, p = 0.132; data not shown).…”

Section: Discussionmentioning

confidence: 99%

“…This means, that in about 95 % of patients with elevated PTH levels, we were able to identify risk factors that could be targeted quite easily by therapeutic interventions. But while there is evidence for positive effects of compensation of hypocalcemia and supplementation of 25(OH)D on sHPT in general populations as well as in HIV-infected populations [23][24][25]40], prospective data about effects of switching from TDF to non-TDF-containing ART on PTH levels are missing. This data seems important as it could help us identify patients at risk for low BMD on TDF but also patients at low risk of bone related complications on TDF-containing ART, and therefore might help us to avoid ART-switches in patients on a stable, well-tolerated therapy.…”

Section: Discussionmentioning

confidence: 99%

Secondary Hyperparathyroidism in HIV-Infected Patients in Central Europe

et al. 2018

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Secondary hyperparathyroidism (sHPT) might be a contributor to increased risk of osteoporosis in adult HIV patients but there is little data available on this issue in this particular population. The aim of the study was to investigate the prevalence of sHPT in an HIV-infected population with normal kidney function and to evaluate its risk factors in HIV patients. This cross-sectional study was carried out in a single HIV center in Germany using routine data from patients with normal kidney function attending the clinic between January 1st and December 31st, 2016. In total, 1263 patients were included [998 (79.0%) male, median age 48 (IQR 38-54) years]. In 214 patients (16.9%) elevated PTH levels with low or normal calcium levels were found. Multivariate logistic regression modeling showed significant associations with elevated PTH for African ethnicity [OR: 2.12 (95% CI: 1.42-3.16); p<0.001], low 25-hydroxyvitamin D levels [OR: 1.82 (95% CI: 1.32-2.51); p<0.001], low calcium levels [OR 1.69 (95% CI: 1.22-2.33); p=0.001], and use of tenofovir disoproxil fumarate [OR 2.33 (95% CI: 1.62-3.36); p<0.001]. Additional to common risk factors like vitamin D insufficiency and hypocalcemia, we found a significant association between the use of TDF and sHPT. Prospective data are needed to ascertain whether PTH-mediated bone loss is the underlying mechanism of TDF bone-toxicity. Additional screening of PTH even in HIV-infected patients with normal or low calcium levels may help to identify patients at increased risk of bone mineral density loss.

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Association of Low Vitamin D with Complications of HIV and AIDS: A literature Review

Chokuda

Reynolds

2020

IDDT

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: With the advent of combination antiretroviral therapy (cART), the survival of HIV patients has improved dramatically, but the complications of the disease and treatment have become an important issue in the management of HIV patients. Vitamin-D deficiency is common in HIV patients. Low vitamin-D is associated with different comorbidities in the HIV uninfected general population. : In this review, we first briefly describe vitamin D synthesis and mechanism of action and we focus on the epidemiological and clinical data dealing with the relationship between vitamin D deficiency in HIV infection with several comorbidities which has been found to be increasingly common in patients living with HIV infection. We searched the PubMed database using the keywords “HIV,” “vitamin D” and other common disorders or conditions that are relatively common in HIV infection. The other conditions included in the search were osteoporosis and fracture, cardiovascular disease, diabetes and insulin resistance, active tuberculosis, hepatitis-C co-infection, and HIV disease progression. Articles presenting original data as well as systematic reviews and met analysis related to HIV population were included in our analysis. : Vitamin-D deficiency seems to be associated with several adverse outcomes in HIV patients but a definite cause and effect relationship with vitamin-D is yet to be confirmed in most of the cases. However, the literature supporting the efficacy of vitamin-D supplementation is lacking.

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Effect of Low Dose Oral Vitamin-D and Calcium Replacement in HIV Patients

Abstract: After 12 months of follow up, replacement of low dose once daily oral vitamin-D with calcium in treatment experienced HIV patients with vitamin-D deficiency can increase vitamin-D level, reduce PTH level without any change in BMD of hip and spine.

Cited by 4 publications

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Serum Levels of Vitamin D, Magnesium, Calcium, Iron, and TIBC in HIV-Infected Patients

Serum Levels of Vitamin D, Magnesium, Calcium, Iron, and TIBC in HIV-Infected Patients

Secondary Hyperparathyroidism in HIV-Infected Patients in Central Europe

Association of Low Vitamin D with Complications of HIV and AIDS: A literature Review

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