Effect of Long-Term Treatment with Antihypertensive Drugs on Quality of Life of Elderly Patients with Hypertension: A Double-Blind Comparative Study between a Calcium Antagonist and a Diuretic.

Abstract

tration. Lower score was seen in 3 categories (general symptoms, sleep scale, and sexual function) in the trichlormethiazide group (p<0.05) and in one category (cognitive function) in the nicardipine group, but there was no significant difference in d score in any of the individual items. In conclusion, the two antihypertensive agents had nearly equivalent effects on QOL in the long-term treatment of hypertension in the elderly and that neither resulted in a deterioration in QOL. (Hypertens Res 2000; 23: 33-37)

Safety and benefits of a tablet combining losartan and hydrochlorothiazide in Japanese diabetic patients with hypertension

“…6 The guidelines of the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, 7 the European Society of Hypertension 8 and Japanese Society of Hypertension 9 also recommend combination therapy comprising ARB and thiazide-type diuretics for hypertensive patients. However, add-on HCTZ may have some adverse effects on electrolyte, glucose, lipid and uric acid metabolism, especially in Japanese diabetic patients with hypertension.…”

Renoprotective Effects of Benidipine in Combination with Angiotensin II Type 1 Receptor Blocker in Hypertensive Dahl Rats

“…Long-acting CCBs in particular have been reported to have favorable effects on hypertension and other cardiovascular diseases. The potent vasodilatory and natriuretic properties of the CCBs are generally recognized as their antihypertensive mechanisms (1). On the other hand, numerous animal studies have demonstrated that the various CCBs differ in their effects on kidney function and glomerular pathology.…”

Questionnaire Survey on the Japanese Guidelines for Treatment of Hypertension in the Elderly: 1999 Revised Version

“…Low-dose thiazide diuretics were also proven to be as effective as calcium antagonists in mega-trials in elderly patients with hypertension in Western countries (14 -16) and in Japan (NICS-EH) (10). However, the withdrawal rate due to side effects was somewhat higher in the thiazide group than in the calcium antagonist group in the NICS-EH (26,27) trial. The survey results indicated that diuretics are currently being used not in monotherapy but rather in combination with other antihypertensives for elderly patients with hypertension in Japan.…”