Questionnaire Survey on the Japanese Guidelines for Treatment of Hypertension in the Elderly: 1999 Revised Version

Azelnidipine and Amlodipine: a Comparison of Their Pharmacokinetics and Effects on Ambulatory Blood Pressure.

“…Calcium antagonists are commonly used for the treatment of hypertension because these drugs have a reliable hypotensive effect with few adverse reactions and are particularly effective in preventing stroke (1)(2)(3)(4)(5).…”

Efficacy of Various Antihypertensive Agents as Evaluated by Indices of Vascular Stiffness in Elderly Hypertensive Patients

“…Hypertension in the elderly is characterized by systolic hypertension, with increased systolic blood pressure (SBP) as a risk factor rather than increased diastolic blood pressure (DBP), and increased pulse pressure (PP) is regarded as critical (1)(2)(3)(4)(5)(6)(7). Pulse pressure is regulated by stroke volume as well as the extensibility of elastic arteries, which are vulnerable to arterial stiffness.…”

The Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) Trial: Rationale and Design

“…In Japan, however, calcium antagonists are the most widely prescribed antihypertensives (21). When a questionnaire survey was administered to Japanese clinical specialists in hypertension to gauge their opinions on the 1999 revised version of the Guidelines for Hypertension in the Elderly, 65% of the respondents selected long-acting calcium antagonists, ACE inhibitors, and low-dose diuretics as first-line agents for the treatment of hypertension without complications in the elderly (28). In addition, it was reported that the combination of a calcium antagonist with an ACE inhibitor or angiotensin receptor blocker was their firstchoice drug combination (20).…”