Effect of long-term ingestion of polyunsaturated fat, age, plasma cholesterol, diabetes mellitus, and supplemental tocopherol upon plasma tocopherol

Lewis, Jane S.; Pian, Anita K.; Baer, Marion Taylor; Acosia, Phyllis B.; Emerson, Gladys A.

doi:10.1093/ajcn/26.2.136

Cited by 30 publications

(7 citation statements)

References 38 publications

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“…Intralipid employs soybean oil as its fat source while Liposyn utilizes safflower oil. Reported values 10 for the relatively or j8 + y tocopherol content of soybean oil average 65% (range 58-73) of total tocopherol; the a tocopherol isomer accounts for an average of 9% (range [4][5][6][7][8][9][10][11][12]. For safflower oil, the relative ~3 + ~y content is 20% (range 17-22) and the a isomer accounts for 61% (range 48-83) of total tocopherol.…”

Section: Discussionmentioning

confidence: 99%

Tocopherol Isomers in Intravenous Lipid Emulsions and Resultant Plasma Concentrations

Gutcher

Lax

Farrell

1984

J Parenter Enteral Nutr

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Conflicting reports exist regarding the relative tocopherol isomer content of Intralipid ranging from 99% as alpha-tocopherol to as much as 90% as gamma-tocopherol. Our direct assay of Intralipid as well as plasma levels measured in premature infants receiving Intralipid confirm the existence of a low alpha, high gamma-tocopherol content and imply the need for alpha-tocopherol supplementation in patients receiving Intralipid, particularly the relatively tocopherol-deficient premature infant. Furthermore, the observation of abnormal erythrocyte hemolysis test values despite "normal" total tocopherol plasma concentrations may be explained by high plasma levels of non-alpha, biologically less active isomers. The quantitation of tocopherol isomers helps explain this discrepancy and suggests the need for future studies of vitamin E status to employ measurements of tocopherol isomers in reporting results.

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Section: Discussionmentioning

confidence: 99%

Tocopherol Isomers in Intravenous Lipid Emulsions and Resultant Plasma Concentrations

Gutcher

Lax

Farrell

1984

J Parenter Enteral Nutr

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“…The few studies which have investigated vitamin E status in the elderly compared with younger people are contradictory, with no change (Vatassery et al 1983), an increase (Lewis et al 1973) or a decrease (Vandewoude & Vandewoude, 1987) being reported. Most studies have failed to extend the range examined to include a significant number of subjects aged over 70 years or take account of the possible confounding effect of plasma lipids on plasma vitamin E levels.…”

mentioning

confidence: 99%

Selenium and vitamin E status of healthy and institutionalized elderly subjects: analysis of plasma, erythrocytes and platelets

et al. 1989

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Levels of selenium in whole blood, plasma, erythrocytes and platelets, glutathione peroxidase (EC 1.11.1.9; GSH-Px) activity in erythrocytes and platelets and vitamin E, low-density-lipoprotein (LDL)-cholesterol and vitamin E: LDL cholesterol in plasma were measured in seventy-five healthy subjects aged < 65 years and twenty-eight healthy and twenty-three institutionalized elderly people aged > 65 years. Healthy elderly subjects had significantly lower levels of Se in whole blood and plasma when compared with younger subjects. Other measurements of Se status were not significantly different. In the healthy subjects plasma levels of vitamin E and LDL-cholesterol increased with age to 60 years and decreased above 80 years. Vitamin E: LDL cholesterol values were not affected by age. Measurements of Se and vitamin E status in the institutionalized elderly compared with the healthy elderly were all reduced with the exception of platelet Se levels and erythrocyte GSH-Px activity. Ageing per se had minimal effect on Se and vitamin E status but intercnrrent illness and decreased food intake can lead to reduced levels in the elderly. Selenium: Vitamin E: Old age.

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“…From these findings, it is assumed that the lack of correlation in this population is probably attributable to the lower concentrations and a narrow range of plasma lipids, because this population included only healthy children. The lower tocopherol concentrations in platelets in children than in adults as shown in this study is likely a reflection of plasma tocopherol concentrations which are usually thought to be lower in children than in adults (17)(18)(19)(20). This must however be denied because of the lack of correlation in tocopherpl level between platelet and plasma.…”

mentioning

confidence: 58%

Tocopherol concentration in platelets in normal children and adults.

Yaoi

Nakagawa

Mind

1984

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Effect of long-term ingestion of polyunsaturated fat, age, plasma cholesterol, diabetes mellitus, and supplemental tocopherol upon plasma tocopherol

Cited by 30 publications

References 38 publications

Tocopherol Isomers in Intravenous Lipid Emulsions and Resultant Plasma Concentrations

Tocopherol Isomers in Intravenous Lipid Emulsions and Resultant Plasma Concentrations

Selenium and vitamin E status of healthy and institutionalized elderly subjects: analysis of plasma, erythrocytes and platelets

Tocopherol concentration in platelets in normal children and adults.

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