Effect of Long-Term Exercise Training on Regional Myocardial Perfusion Changes in Patients With Coronary Artery Disease

Linxue, Li; Nohara, Ryuji; Makita, Shigeru; Hosokawa, R.; Hata, Toshimitsu; Okuda, Kazumi; Hamazaki, Hiroshi; Fujita, Masatoshi; Sasayama, Shígetake

doi:10.1253/jcj.63.73

Cited by 21 publications

(9 citation statements)

References 24 publications

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“…21,22 Thirty patients had coronary heart diseases (CHD) (19 with myocardial infarction, 11 with angina pectoris). Three patients had 3-vessel disease, 8 patients had 2-vessel disease, and 19 patients had 1-vessel disease.…”

Section: Subjectsmentioning

confidence: 99%

Immune Function and Psychological Factors in Patients With Coronary Heart Disease (I)

et al. 1999

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Section: Subjectsmentioning

confidence: 99%

Immune Function and Psychological Factors in Patients With Coronary Heart Disease (I)

et al. 1999

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“…Also, it has been observed that CR has a direct influence on the myocardium, and it increases the myocardial perfusion which in turn increases the exercise capacity. This was confirmed by cardiac magnetic resonance imaging and quantitative positron emission tomography myocardial flow reserve (PET-MFR) assessments [33343536]. These previous studies have shown that CR has a significant benefit in recovery of LV function after LV remodeling.…”

Section: Discussionmentioning

confidence: 72%

The Effect of Cardiac Rehabilitation Exercise Training on Cardiopulmonary Function in Ischemic Cardiomyopathy With Reduced Left Ventricular Ejection Fraction

2016

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ObjectiveTo observe the effect and safety of cardiac rehabilitation (CR) exercise in ischemic cardiomyopathy and to compare the results between patients with preserved left ventricular ejection fraction (LVEF) and reduced LVEF.MethodsPatients with ischemic cardiomyopathy with LVEF <50% were included as subjects. The patients were classified into the preserved LVEF (pLVEF; LVEF 41%–49%) group and the reduced LVEF (rLVEF; LVEF ≤40%) group. Patients underwent hourly aerobic exercise training sessions with an intensity of 60%–85% of heart rate reserve, three times a week for 6 weeks. Graded exercise test and transthoracic echocardiogram were performed in all study patients before and after completion of the CR exercise program.ResultsAfter completion of the CR exercise program, both groups (pLVEF, n=30; rLVEF, n=18) showed significant increases in LVEF and VO2max. In the pLVEF group, LVEF and VO2max increased from 45.1%±4.8% to 52.5%±9.6% (p<0.001) and from 24.1±6.3 to 28.1±8.8 mL/kg/min (p=0.002), respectively. In the rLVEF group, LVEF and VO2max increased from 29.7%±7.7% to 37.6%±10.3% (p<0.001) and from 17.6±4.7 to 21.2±5.1 mL/kg/min (p<0.001), respectively. Both groups completed their exercise program safely.ConclusionIn both groups, patients with ischemic cardiomyopathy who completed a 6-week supervised CR exercise program demonstrated remarkable improvements in cardiopulmonary function. This result implies that neither of the two groups showed higher efficacy in comparison to each other, but we can conclude that CR exercise in the rLVEF group was as effective and safe as that in the pLVEF group.

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“…4 Epidemiologically, physical activity is associated with a decrease in the risk of coronary heart disease, 5 but the effect of physical training on LV dysfunction in the early phase of the recovery process following AMI has not been sufficiently investigated, especially in patients who have undergone successful coronary angioplasty. In fact, there have been conflicting reports 7,10 of the effects of exercise training on ventricular function or remodeling after MI and it has been unclear about the involvement of coronary angioplasty or residual ischemia.…”

Section: Discussionmentioning

confidence: 99%

Improvement of Left Ventricular Dysfunction During Exercise by Walking in Patients With Successful Percutaneous Coronary Intervention for Acute Myocardial Infarction.

Koizumi

Miyazaki

Komiyama

et al. 2003

Circ J

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alking is associated with a lower overall mortality rate in older physically capable men 1 and with the prevention of coronary heart disease in women, 2 but it is not known whether walking is beneficial for ventricular function. Moreover, the specific effect of walking (ie, low-intensity activity) on the remodeling process in patients who have had a myocardial infarction (MI) and who have undergone successful coronary angioplasty has not been fully elucidated.We examined the effect of a 3-month walking program on left ventricular function in patients who have had successful percutaneous coronary intervention (PCI) for acute MI (AMI). Methods Patient SelectionFrom August 1998 to May 1999, 30 patients aged less than 80 years who had survived an AMI at Chiba University Hospital were studied. All patients had a typical history of chest pain, ST segment elevation of at least 2 mm, or ST-T abnormalities in 2 continuous precordial electrocardiographic (ECG) leads, persistent asynergy evaluated by 2-dimensional echocardiography or by left ventriculogram, and a typical pattern of elevated concentrations of serum Circulation Journal Vol.67, March 2003 myocardial enzymes. Exclusion criteria were arrhythmia (ie, atrial fibrillation, bundle branch block, frequent extrasystole), failed PCI (ie, inadequate coronary reflow; residual diameter stenosis >50% in the infarct-related artery), significant valvular heart disease, contraindications for exercise, signs or symptoms of cardiac failure, rest left ventricular ejection fraction (LVEF) less than 30% on echocardiography, echocardiographic images of inadequate quality for quantitative analysis, inability to give informed consent, malignant disease or life-threatening disease at entry to the study, or an orthopedic or neurological disorder of walking. When the patients arrived at hospital within 12 h of the onset of MI, they underwent emergency PCI (9 patients), or if more than 12 h had passed after the onset, and there was no chest pain at rest, no recurrent arrhythmia because of ischemia recorded on ECG and the patient's hemodynamics were stable, elective PCI was performed after cardiac rehabilitation of approximately 1 week (21 patients). We did not perform thrombolytic therapy in all patients.One month after PCI (ie, baseline), the patients were randomly allocated to either a 3-month training program of walking (group W: 15 patients) or a control group (group C: 15 patients). All patients underwent functional evaluation at Chiba University Hospital at both the beginning and end of the study (ie, after the 3-month training program): physical examination, heart rate, blood pressure, and a standard supine exercise stress testing on a bicycle ergometer with 2-dimensional B-mode echocardiography. Reinfarction, heart failure or angina were the clinical end-points and the criteria for withdrawing patients from the study. Protocol of the Walking ProgramWe recommended the patients in group W use a pedome- A growing body of evidence suggests that walking reduces the incidence of cor...

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Effect of Long-Term Exercise Training on Regional Myocardial Perfusion Changes in Patients With Coronary Artery Disease

Cited by 21 publications

References 24 publications

Immune Function and Psychological Factors in Patients With Coronary Heart Disease (I)

Immune Function and Psychological Factors in Patients With Coronary Heart Disease (I)

The Effect of Cardiac Rehabilitation Exercise Training on Cardiopulmonary Function in Ischemic Cardiomyopathy With Reduced Left Ventricular Ejection Fraction

Improvement of Left Ventricular Dysfunction During Exercise by Walking in Patients With Successful Percutaneous Coronary Intervention for Acute Myocardial Infarction.

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