Effect of long-term CCK blockade on the pancreatic acinar cell renewal in rats with acute pancreatitis

Mano, A.M de la; Sevillano, Sara; Manso, Manuel A.; Dios, Isabel De

doi:10.1016/s0196-9781(03)00112-8

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Exocrine Pancreas1

Specific Aspects Of Cck Receptor Function In the Pancreas1

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2006

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Cited by 2 publications

(2 citation statements)

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“…ACh, acetylcholine; CNS, central nervous system. injection of agonists or antagonists (118,150,319,387). Conversely, CCK-and CCK1R-deficient mice demonstrate that CCK is not a required growth factor for the murine pancreas (263,513), nor is CCK1R required for the growth of the guinea pig pancreas (202).…”

Section: Exocrine Pancreasmentioning

confidence: 99%

Cholecystokinin and Gastrin Receptors

Dufresne

Seva²,

Fourmy³

2006

Physiological Reviews

417

418

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Cholecystokinin and gastrin receptors (CCK1R and CCK2R) are G protein-coupled receptors that have been the subject of intensive research in the last 10 years with corresponding advances in the understanding of their functioning and physiology. In this review, we first describe general properties of the receptors, such as the different signaling pathways used to exert short- and long-term effects and the structural data that explain their binding properties, activation, and regulation. We then focus on peripheral cholecystokinin receptors by describing their tissue distribution and physiological actions. Finally, pathophysiological peripheral actions of cholecystokinin receptors and their relevance in clinical disorders are reviewed.

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Section: Exocrine Pancreasmentioning

confidence: 99%

Cholecystokinin and Gastrin Receptors

Dufresne

Seva²,

Fourmy³

2006

Physiological Reviews

417

418

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“…In addition to effects on secretion, CCK can exert trophic and proliferative effects on the pancreas mediated by the CCK1R. The essential contribution of CCK1R for pancreatic regeneration following pancreatectomy or pancreatic duct ligation and the importance of CCK for normal pancreatic growth has also been reported in rats (8,50,53,60). Conversely, studies in mice and guinea pigs deficient in CCK peptide and CCK1R have demonstrated that CCK is not a required growth factor for the murine pancreas (43,73).…”

Section: Specific Aspects Of Cck Receptor Function In the Pancreasmentioning

confidence: 99%

Cholecystokinin Type 1 Receptor

Desai¹,

Miller

The Pancreapedia: Exocrine Pancreas Knowledge Base

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Effect of long-term CCK blockade on the pancreatic acinar cell renewal in rats with acute pancreatitis

Cited by 2 publications

References 38 publications

Cholecystokinin and Gastrin Receptors

Cholecystokinin and Gastrin Receptors

Cholecystokinin Type 1 Receptor

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