Cholecystokinin Type 1 Receptor

Desai, Aditya J.; Miller, Laurence J.

doi:10.3998/panc.2013.9

Cited by 3 publications

(1 citation statement)

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“…The action of CCK on tissues is mediated by two G protein-coupled receptors, CCK1 and CCK2, formerly known as CCK-A (for alimentary) and CCK-B (for brain) (17). CCK1 receptors are mainly located in the gastrointestinal tract, myenteric plexus, and vagal afferents and bind sulfated CCK with 1000-fold higher affinity than gastrin or nonsulfated CCK (16). CCK2 receptors are present in the stomach and the brain and have similar affinity for sulfated or non-sulfated CCK and for gastrin; hence this receptor is also known as the gastrin receptor.…”

Section: Cholecystokinin Receptorsmentioning

confidence: 99%

Cholecystokinin

Pancreapedia: Exocrine Pancreas Knowledge Base

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Section: Cholecystokinin Receptorsmentioning

confidence: 99%

Cholecystokinin

Pancreapedia: Exocrine Pancreas Knowledge Base

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Cholecystokinin (CCK) Regulation of Pancreatic Acinar Cells: Physiological Actions and Signal Transduction Mechanisms

Williams

2019

Comprehensive Physiology

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Pancreatic acinar cells synthesize and secrete about 20 digestive enzymes and ancillary proteins with the processes that match the supply of these enzymes to their need in digestion being regulated by a number of hormones (CCK, secretin and insulin), neurotransmitters (acetylcholine and VIP) and growth factors (EGF and IGF). Of these regulators, one of the most important and best studied is the gastrointestinal hormone, cholecystokinin (CCK). Furthermore, the acinar cell has become a model for seven transmembrane, heterotrimeric G protein coupled receptors to regulate multiple processes by distinct signal transduction cascades. In this review, we briefly describe the chemistry and physiology of CCK and then consider the major physiological effects of CCK on pancreatic acinar cells. The majority of the review is devoted to the physiologic signaling pathways activated by CCK receptors and heterotrimeric G proteins and the functions they affect. The pathways covered include the traditional second messenger pathways PLC‐IP3‐Ca 2+ , DAG‐PKC, and AC‐cAMP‐PKA/EPAC that primarily relate to secretion. Then there are the protein‐protein interaction pathways Akt‐mTOR‐S6K, the three major MAPK pathways (ERK, JNK, and p38 MAPK), and Ca 2+ ‐calcineurin‐NFAT pathways that primarily regulate non‐secretory processes including biosynthesis and growth, and several miscellaneous pathways that include the Rho family small G proteins, PKD, FAK, and Src that may regulate both secretory and nonsecretory processes but are not as well understood. © 2019 American Physiological Society. Compr Physiol 9:535‐564, 2019.

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Anorexia, Appetite, Hunger, and Satiety in Older Adults

Pitchumoni

Chaudhari

2021

Geriatric Gastroenterology

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Cholecystokinin Type 1 Receptor

Cited by 3 publications

References 92 publications

Cholecystokinin

Cholecystokinin

Cholecystokinin (CCK) Regulation of Pancreatic Acinar Cells: Physiological Actions and Signal Transduction Mechanisms

Anorexia, Appetite, Hunger, and Satiety in Older Adults

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