Effect of Long Chain Fatty Acids on Bacterial Respiration and Amino Acid Uptake

Galbraith, H.; Miller, T. B.

doi:10.1111/j.1365-2672.1973.tb04151.x

Cited by 145 publications

(88 citation statements)

References 26 publications

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“…Similar results were obtained with FAME extracts of leaves of Ipomoea pes-caprae and lipophylic extracts of various plant parts of Pistacia vera (4,12). These differences in the fatty acid sensitivities between Gram-positive and Gram-negative bacteria may result from the impermeability of the outer membrane of Gram-negative bacteria since the outer membrane of Gram-negative bacteria is an effective barrier against hydrophobic substances (5,16). In fact, Gramnegative bacteria are more resistant to inactivation by medium and long chain fatty acids than Gram-positive bacteria (7).…”

Section: Resultssupporting

confidence: 68%

Antibacterial and antifungal activities of fatty acid methyl esters of the blind-your-eye mangrove from India

Agoramoorthy¹,

Chandrasekaran²,

Venkatesalu³

et al. 2007

Braz. J. Microbiol.

356

194

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Fatty acids are widely occurring in natural fats and dietary oils and they are known to have antibacterial and antifungal properties. However, little is known on the antibacterial and antifungal properties of the blindyour-eye mangrove (Excoecaria agallocha) and this study for the first time determines the fatty acid composition and the antibacterial and antifungal activities of Fatty Acid Methyl Esters (FAME) of the blindyour-eye mangrove plant found along the coastal areas of south India.

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Section: Resultssupporting

confidence: 68%

Antibacterial and antifungal activities of fatty acid methyl esters of the blind-your-eye mangrove from India

Agoramoorthy¹,

Chandrasekaran²,

Venkatesalu³

et al. 2007

Braz. J. Microbiol.

356

194

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“…s.e.m., standard error of the mean (concentration) suggested by Zhang et al (2008), is likely to have been due to the direct action of unsaturated fatty acids against methanogens and protozoa associated with methanogens. According to earlier research in this area, the toxicity of unsaturated fatty acids towards microorganisms can be explained on a physiochemical basis, namely that fatty acids form adsorption layers around the bacterial cell, which results in altered cell permeability (Kodicek and Worden 1945) and therefore interferes with nutrient uptake (Galbraith and Miller 1973).…”

Section: Fatty Acidsmentioning

confidence: 99%

Reducing in vitro rumen methanogenesis for two contrasting diets using a series of inclusion rates of different additives

et al. 2014

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Abstract. Eleven individual additives were incubated with either perennial ryegrass or with grass silage+barley grain (50 : 50) and the in vitro methane output was assessed using the gas production technique (GPT). Additives were: fatty acids (lauric, oleic, linoleic and linolenic acids), halogenated methane analogues (bromoethanesulfonate and bromochloromethane), pyromellitic diimide, statins (mevastatin and lovastatin), a probiotic (Saccharomyces cerevisiae) and an unsaturated dicarboxylic acid (fumaric acid). Each additive was included at a range of concentrations. Effects on methane output per gram of feed dry matter (DM) incubated (CH 4 /DMi) and disappeared (CH 4 /DMd), as well as other fermentation variables, were evaluated after 24 h of incubation. The addition of increased concentrations of individual fatty acids, bromoethanesulfonate and pyromellitic diimide caused a dose-dependent decline in methane output (CH 4 /DMi, CH 4 / DMd), when incubated with either perennial ryegrass or grass silage+barley grain. No methane output was detected for either feed with the addition of !5 mM bromochloromethane. The statins were ineffective inhibitors of methane output regardless of feed type. For perennial ryegrass, S. cerevisiae caused a dose-dependent decline in CH 4 /DMd and fumaric acid a dose-dependent decline in CH 4 /DMi and CH 4 /DMd. The effectiveness of lauric, oleic, linoleic and linolenic acids and bromoethanesulfonate to reduce methane output was more pronounced when incubated with grass silage+barley grain than with perennial ryegrass, and therefore the type of feed is an important component for any future in vitro and in vivo studies to be undertaken with these additives. Thus, incorporating different feed types in the initial in vitro screening protocols of all new additives is recommended.Additional keywords: in vitro total gas production technique, rumen fermentation modifiers, ruminant diets.

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“…In humans and mice, these two 16-carbon monounsaturated fatty acids block the growth of S. aureus in the skin [29][30][31]. It has been hypothesized that fatty acids act by destabilizing the lipid bilayers of the bacterial membrane and disrupting the membrane functions [32] due to a range of effects on cellular metabolism [33][34][35][36][37][38].…”

Section: Gc-ms Spectroscopymentioning

confidence: 99%

In vitro activity, extraction, separation and structure elucidation of antibiotic produced by Streptomyces anulatus NEAE-94 active against multidrug-resistant Staphylococcus aureus

El‐Naggar

El-Bindary

Abdel-Mogib

et al. 2017

Biotechnology & Biotechnological Equipment

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During the screening programme for antibiotic produced by actinomycetes, an antibiotic was isolated from the fermentation broth of Streptomyces anulatus NEAE-94. The ethyl acetate extract of S. anulatus NEAE-94 showed high biological activity against Staphylococcus aureus NRRL B-313, multidrug-resistant S. aureus and Bacillus subtilis NRRL B-543. Thin-layer chromatography of the ethyl acetate extract showed one yellowish orange spot with an Rf value of 0.83. The structural elucidation of the isolated compounds was carried out using ultraviolet-visible mass spectrometry (MS), Fourier transform-infrared spectroscopy (FT-IR), proton nuclear magnetic resonance ( 1 H-NMR) and gas chromatography-mass spectrometry (GC-MS) analyses. Characterization of the ethyl acetate extract revealed the presence of 22 compounds, including an unsaturated fatty acid, saturated fatty acids, fatty acid esters, alkanes, alkenes and a triterpene. The antimicrobial efficacy of S. anulatus NEAE-94 might be due to the synergistic effects of the identified compounds.

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Effect of Long Chain Fatty Acids on Bacterial Respiration and Amino Acid Uptake

Cited by 145 publications

References 26 publications

Antibacterial and antifungal activities of fatty acid methyl esters of the blind-your-eye mangrove from India

Antibacterial and antifungal activities of fatty acid methyl esters of the blind-your-eye mangrove from India

Reducing in vitro rumen methanogenesis for two contrasting diets using a series of inclusion rates of different additives

In vitro activity, extraction, separation and structure elucidation of antibiotic produced by Streptomyces anulatus NEAE-94 active against multidrug-resistant Staphylococcus aureus

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