Effect of local injection of 8-OH-DPAT into the dorsal or median raphe nuclei on extracellular levels of serotonin in serotonergic projection areas in the rat brain

Bonvento, Gilles; Scatton, B.; Claustre, Y.; Rouquier, L.

doi:10.1016/0304-3940(92)90308-t

Cited by 122 publications

(57 citation statements)

References 16 publications

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“…Extracellular 5-HT was measured simultaneously in the ventral striatum and ventral hippocampus, as previous investigation has suggested that these terminal field regions are differentially regulated by 5-HT 1A autoreceptors in the dorsal and median raphe nuclei (Bonvento et al, 1992;Kreiss and Lucki, 1994). In accordance with previous studies, acute administration of the 5-HT 1A receptor agonist 8-OH-DPAT decreased 5-HT release in the striatum (Hjorth and Sharp, 1991;Kreiss and Lucki, 1992) and in the hippocampus (Auerbach et al, 1989;Kreiss and Lucki, 1994;Sharp et al, 1989a).…”

Section: Discussionmentioning

confidence: 99%

“…The present study replicated and extended these preliminary observations by comparing desensitization of 5-HT 1A autoreceptors that regulate the release of 5-HT in the striatum and the hippocampus. Previous studies demonstrated that the 5-HT 1A autoreceptors regulating release in the striatum are located in the dorsal raphe nucleus, whereas the 5-HT 1A autoreceptors regulating release in the hippocampus are located in the median raphe nucleus (Bonvento et al, 1992;Kreiss and Lucki, 1994). Alterations in the effects of a challenge administration of 8-OH-DPAT were examined in both regions following 1, 7, or 14 days of pretreatment with 8-OH-DPAT.…”

Section: Introductionmentioning

confidence: 97%

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Chronic administration of the 5-HT1A receptor agonist 8-OH-DPAT differentially desensitizes 5-HT1A autoreceptors of the dorsal and median raphe nuclei

Kreiss

Lucki

1997

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The present study investigated alterations of the regulation of serotonin (5-hydroxytryptamine; 5-HT) release by 5-HT1A autoreceptors following single and repeated treatment with the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT). Rats were pretreated with 8-OH-DPAT (1.0 mg/kg, s.c.) for 1, 7, or 14 days. The ability of an acute challenge administration of 8-OH-DPAT (1.0 mg/kg, i.p.) to decrease 5-HT release in the ventral striatum and the ventral hippocampus of rats maintained under chloral hydrate anesthesia was examined 24 h after the last pretreatment injection using in vivo microdialysis. The decrease of 5-HT release in the striatum produced by the challenge dose of the 5-HT1A receptor agonist was diminished following 7 and 14 days of pretreatment, but not after 1 day of pretreatment, with 8-OH-DPAT. In contrast, decreases of 5-HT release in the hippocampus by the 8-OH-DPAT challenge were not altered after 1 or 7 days of pretreatment, and only a trend for attenuation appeared after pretreatment for 14 days. The results of the present study indicate that desensitization of 5-HT1A autoreceptors regulating 5-HT release in different brain regions by repeated treatment with 8-OH-DPAT occurs at different rates.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Chronic administration of the 5-HT1A receptor agonist 8-OH-DPAT differentially desensitizes 5-HT1A autoreceptors of the dorsal and median raphe nuclei

Kreiss

Lucki

1997

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“…It is nevertheless conceivable that if the solution injected diffused to the Sylvius aqueduct, located immediately above the dorsal raphe, a small amount of agonist could find its way to the third ventricle and reach to the hypothalamus located just rostrally to the dorsal raphe. Indeed, the above-mentioned experiments were carried out using 0.5 L, whereas Bonvento et al (1992) showed that only a volume of 0.1 L of [ 3 H]8-OH-DPAT injected in that region of the brainstem remained confined to the dorsal raphe. Furthermore, it was noted in the work of Higgins et al (1988) that the amount of 8-OH-DPAT (injected directly into the dorsal raphe) necessary to produce hypothermia was 25 times greater than that necessary to trigger behavioral modifications.…”

Section: Discussionmentioning

confidence: 99%

Serotonin 1A Receptor Activation and Hypothermia in Humans Lack of Evidence for a Presynaptic Mediation

Blier

Seletti

Gilbert

et al. 2002

Neuropsychopharmacology

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The hypothermia produced by 5-HT 1A 1A receptors are located both on the cell body of 5-HT neurons and on postsynaptic neurons throughout the central nervous system. On 5-HT neurons, 5-HT 1A receptors mediate a negative feedback influence on firing activity. When overactivated by an excess amount of 5-HT, or by an exogenous agonist, they slow down the pacemaker activity leading to a decreased firing rate of 5-HT neurons (Aghajanian and Lakoski 1984;Blier and de Montigny 1987). As 5-HT release is proportional to firing rate, the excess activation of these 5-HT 1A autoreceptors generally results in a decrease of 5-HT release in projecting structures (see Rueter et al. Gainesville, FL 32610, Tel.: 352-392-3681, Fax : 352-392-2579, E-mail : blier@psych.med.ufl.edu Received May 11, 2001 revised January 16, 2002; accepted February 20, 2002. Online publication: 2/27/02 at www.acnp.org/citations/ Npp022702253. 302 P. Blier et al. N EUROPSYCHOPHARMACOLOGY 2002 -VOL . 27 , NO . 2 1997). The postsynaptic 5-HT 1A receptors, particularly abundant in the limbic system, commonly exert an inhibitory function on neuronal activity as well. Therefore, the net effect of the systemic administration of a 5-HT 1A receptor agonist on 5-HT 1A signal transfer in postsynaptic areas represents a composite of decreased 5-HT release, resulting from 5-HT 1A autoreceptor activation, and direct occupation of the postsynaptic 5-HT 1A receptors.Although it is well established that neuroendocrine responses, such as growth hormone and adenocorticotropic hormone release, produced by systemic administration of 5-HT 1A agonists are mediated by postsynaptic 5-HT 1A receptors (Van de Kar et al. 1985;Gilbert et al. 1988;Pan and Gilbert 1992), there has been controversy with respect to the hypothermia resulting from this pharmacological challenge. The very first study examining the pre-versus postsynaptic mediation of the hypothermia clearly indicated that this response was produced by postsynaptic 5-HT 1A receptors (Hjörth 1985). Indeed, this initial study clearly showed that the hypothermic response to the prototypical 5-HT 1A agonist 8-OH-DPAT was not attenuated, but even enhanced in rats pretreated daily for 3 days with the 5-HT synthesis inhibitor parachlorophenylalanine (PCPA). Subsequently, identical results were obtained by another group of investigators using 2-day injections of a higher dose of PCPA (Goodwin et al. 1987). When their PCPA treatment was prolonged, however, for 14 days, despite producing its maximal effect on 5-HT levels after the first 3 days, the 8-OH-DPATinduced hypothermia was dampened and the conclusion of a presynaptic mediation of this phenomenon was made. From then on, several studies carried out in laboratory animals and humans used the 5-HT 1A -induced hypothermia to assess the responsiveness of the 5-HT 1A autoreceptor in different disease states and following administration of various types of psychotropic drugs. Although the majority of studies (Hutson et al. 1987;O'Connell et al. 1992;Hillegaart 1991;Mill...

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“…A plausible mechanism explaining 8-OH-DPAT effect involves 5-HT1A somatodendritic autoreceptors, which are expressed on cell bodies of serotonergic neurons. Stimulation of these autoreceptors is responsible for a decrease in neuronal firing and consequently in the amount of 5-HT released in terminal areas, notably in forebrain and hypothalamus (Sharp et al, 1989;Bonvento et al, 1992). However, these results have to be interpreted cautiously, in view of more recent findings strongly suggesting that brain dopamine D 2 -like receptors mediate the proejaculatory action of 8-OH-DPAT (Matuszewich et al, 1999;Clément et al, 2006b).…”

Section: B Spinal Cordmentioning

confidence: 99%

Pharmacology for the Treatment of Premature Ejaculation

Giuliano

Clément

2012

Pharmacol Rev

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Effect of local injection of 8-OH-DPAT into the dorsal or median raphe nuclei on extracellular levels of serotonin in serotonergic projection areas in the rat brain

Cited by 122 publications

References 16 publications

Chronic administration of the 5-HT1A receptor agonist 8-OH-DPAT differentially desensitizes 5-HT1A autoreceptors of the dorsal and median raphe nuclei

Chronic administration of the 5-HT1A receptor agonist 8-OH-DPAT differentially desensitizes 5-HT1A autoreceptors of the dorsal and median raphe nuclei

Serotonin 1A Receptor Activation and Hypothermia in Humans Lack of Evidence for a Presynaptic Mediation

Pharmacology for the Treatment of Premature Ejaculation

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