Chronic administration of the 5-HT1A receptor agonist 8-OH-DPAT differentially desensitizes 5-HT1A autoreceptors of the dorsal and median raphe nuclei

Kreiss, Deborah S.; Lucki, Irwin

doi:10.1002/(sici)1098-2396(199702)25:2<107::aid-syn1>3.0.co;2-g

Cited by 52 publications

(22 citation statements)

References 41 publications

(57 reference statements)

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“…This behavioral pattern of response is consistent with 8-OH-DPAT decreasing 5-HTrelease, as well as with increasing NA-neuronal firing and NA-release (Casanovas et al 1997;Kreiss and Lucki 1997;Piercey et al 1994).…”

Section: Discussionsupporting

confidence: 62%

Idazoxan and 8-OH-DPAT Modify the Behavioral Effects Induced by Either NA, or 5-HT, or Dual NA/5-HT Reuptake Inhibition in the Rat Forced Swimming Test

Reneric

Bouvard

Stinus

2001

Neuropsychopharmacology

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The rat forced swimming test (FST) predicts the efficacy of antidepressants, which decrease immobility duration in the test, and can distinguish selective serotonin (5-HT) and noradrenaline (NA) reuptake inhibitors, which, respectively, increase swimming and climbing behaviors. However, dual 5-HT and NA reuptake-inhibition produces climbing behavior solely, thereby suggesting with other data that the NA-system mediates inhibiting interactions on 5-HT-induced swimming in the FST. Since ␣ 2 -adrenoreceptors and 5-HT 1A -receptors have important regulatory functions and are involved in 5-HT/NA interactions, we examined whether the ␣ 2 -receptorantagonist idazoxan and the 5-HT 1A -receptor-agonist 8-hydroxy-2-(di-n -propylamino)-tetralin (8-OH-DPAT) would modify the behavioral pattern induced in the FST by either selective or non-selective antidepressant treatments. The rats were treated subacutely (3 injections IP over 48 h) with: (a) idazoxan (0.5-10 mg/kg) alone, and in combination with desipramine (10 mg/kg), or desipramine ϩ fluoxetine (10/10 mg/kg), or the dual serotonin/ noradrenaline reuptake-inhibitor milnacipran (20 mg/kg). (b) 8-OH- (Porsolt et al. 1977(Porsolt et al. , 1978(Porsolt et al. , 1979, which detects all the major classes of antidepressant treatments (Borsini and Meli 1988) NO . 4 (MAOIs), atypical antidepressants, and electroconvulsive shock. The FST is also used to investigate the mechanisms of action of antidepressant drugs (Borsini 1995) or the functional interactions that occur when antidepressants are administered (Redrobe and Bourin 1999;Rénéric and Lucki 1998). The rat FST consists of placing the animal in a jar filled with water for a pre-test on day 1, and for a five-minute test session 24 hours later, with the drugs being administered sub-acutely (3 injections) between the two sessions. The animal first attempts to escape and then progressively adopts an immobile posture, making only small movements to keep its head above water. Effective antidepressant treatments decrease the duration of immobility in the test session (Porsolt et al. 1978). Other methods of scoring the FST take into account swimming and climbing, two main active behaviors occurring in the test, which contribute to the antidepressant-like decrease in immobility-duration (Detke et al. 1995b). This procedure showed that noradrenaline (NA)-reuptake inhibitors (NRIs) and selective serotonin (5-hydroxytryptamine/ 5-HT)-reuptake inhibitors (SSRIs) increased selectively and respectively climbing and swimming behavior (Detke et al. 1995b). This technique can thus distinguish components to the behavioral response to antidepressants (Lucki 1997), which is in agreement with distinguishable neurochemical and behavioral contributions to the therapeutic effects of antidepressants in humans (Heninger et al. 1996;Katz et al. 1994).Serotonin and noradrenaline systems are directly involved in the pathogenesis and the recovery from depression (Blier et al. 1990;Caldecott Hazard et al. 1991), and there were clinical suggestions that...

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Section: Discussionsupporting

confidence: 62%

Idazoxan and 8-OH-DPAT Modify the Behavioral Effects Induced by Either NA, or 5-HT, or Dual NA/5-HT Reuptake Inhibition in the Rat Forced Swimming Test

Reneric

Bouvard

Stinus

2001

Neuropsychopharmacology

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“…It might be argued that such a partial agonist action of (-)-pindolol at 5-HT 1A autoreceptors is inconsistent with its minimal suppressive influence upon FCX levels of 5-HT seen herein and in other studies (Assie and Koek 1996;Hjorth and Sharp 1993;Sharp and Hjorth 1990). However, 1) the firing rate of dorsal raphe nucleus neurones is not invariably reflected in release at the terminal level (Davidson and Stamford 1998); 2) there are regional differences in the effects of 5-HT 1A autoreceptor stimulation upon postsynaptic levels of 5-HT (Invernizzi et al 1997;Kreiss and Lucki 1997;Malagié et al 1996;Romero and Artigas 1997); and 3) antagonist actions at 5-HT 1B terminals (see below) may mask its partial agonist actions at raphe-localized 5-HT 1A receptors (Assie and Koek 1996). In any case, the antagonist actions of (-)-pindolol at 5-HT 1A autoreceptors clearly prevailed in its antagonism of the inhibitory influence of 8-OH-DPAT upon FCX levels of 5-HT seen herein and elsewhere (Sharp and Hjorth 1990) (Figure 2).…”

Section: Discussioncontrasting

confidence: 55%

“…There exist, however, conflicting experimental data concerning the desensitization of 5-HT 1A autoreceptors upon their chronic stimulation by treatment with SSRIs or direct agonists Hjorth and Auerbach 1994;Kreiss and Lucki 1997;Le Poul et al 1995). Furthermore, several questions remain concerning the mechanism(s) underlying the apparent ability of (-)-pindolol to enhance the actions of AD agents.…”

mentioning

confidence: 99%

Modulation of Dialysate Levels of Dopamine, Noradrenaline, and Serotonin (5-HT) in the Frontal Cortex of Freely-Moving Rats by (-)-Pindolol Alone and in Association with 5-HT Reuptake Inhibitors Comparative Roles of β-Adrenergic, 5-HT1A, and 5-HT1B Receptors

Gobert

Millan

1999

Neuropsychopharmacology

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“…It is a well-known phenomenon that repeated administration of a receptor ligand can lead to desensitization of the respective receptor; the problem, however, is whether the 5-HT1A autoreceptor was indeed desensitized in the experiments conducted by Swain and Maric. First of all, although the desensitization of 5-HT 1A autoreceptors has been described in several articles, 28,29 some inconsistent reports have also appeared. For example, desensitization has been reported to occur with the 5-HT 1A receptor agonist alnespirone, but not with 8-OH DPAT.…”

Section: Discussionmentioning

confidence: 99%

Fatigue of cholestasis and the serotoninergic neurotransmitter system in the rat

et al. 2005

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Fatigue associated with cholestasis may impair health-related quality of life. The pathogenesis of this symptom is largely unknown, but it has been suggested that central serotoninergic neurotransmission may be implicated and that serotonin 1A receptor agonists may yield improvement. The aim of this study was to study the central serotoninergic system, specifically the serotonin (5-HT) 1A receptor-mediated pathway of serotoninergic neurotransmission, in a bile duct resection rat model of cholestasis. Fatigue was assessed in the forced swim test in sham and bile duct-resected rats. The serotonin behavioral syndrome, which includes hyperlocomotion, was assessed in both groups of rats after escalating doses of the 5-HT 1A receptor agonist 8-hydroxy(di-n-propylamine)tetralin (8-OH DPAT). 5-HT 1A and 5-HT 2 receptor densities were explored in four brain regions using a receptor-binding assay. Extracellular 5-HT and 5-hydroxyindoleacetic acid were measured via in vivo brain dialysis. Bile duct-resected rats spent more time floating in the forced swim test, and 8-OH DPAT decreased floating time in cholestatic rats (P < .01). Dose-response curves created with 8-OH DPAT for the serotonin behavioral syndrome were similar in bile duct-resected and sham-operated rats. 5-HT 1A and 5-HT 2 receptor densities in most brain regions and extracellular serotonin levels were similar in both groups of rats. In conclusion, 5-HT 1A receptor agonist-induced amelioration of fatigue in cholestatic rats may be nonspecific and not linked to reversal of the pathophysiology of fatigue associated with cholestasis; however, these data do not exclude a potential role of the central serotoninergic system in the evolution of fatigue. (HEPATOLOGY 2005;41:731-737.)

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Chronic administration of the 5-HT1A receptor agonist 8-OH-DPAT differentially desensitizes 5-HT1A autoreceptors of the dorsal and median raphe nuclei

Cited by 52 publications

References 41 publications

Idazoxan and 8-OH-DPAT Modify the Behavioral Effects Induced by Either NA, or 5-HT, or Dual NA/5-HT Reuptake Inhibition in the Rat Forced Swimming Test

Idazoxan and 8-OH-DPAT Modify the Behavioral Effects Induced by Either NA, or 5-HT, or Dual NA/5-HT Reuptake Inhibition in the Rat Forced Swimming Test

Modulation of Dialysate Levels of Dopamine, Noradrenaline, and Serotonin (5-HT) in the Frontal Cortex of Freely-Moving Rats by (-)-Pindolol Alone and in Association with 5-HT Reuptake Inhibitors Comparative Roles of β-Adrenergic, 5-HT1A, and 5-HT1B Receptors

Fatigue of cholestasis and the serotoninergic neurotransmitter system in the rat

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