Effect of local antimicrobial agents on excisional palatal wound healing: a clinical and histomorphometric study in rats

Abstract

Each tested antimicrobial agent when applied on an excisional wound with epithelial and connective tissue deficiency did not have a negative effect on the rate of wound closure. The best results were achieved with 1%CHX gel and Listerine.

Cytological Assessment of Healing Palatal Donor Site Wounds and Grafted Gingival Wounds after Application of Ozonated Oil: An Eighteen-Month Randomized Controlled Clinical Trial

“…Several study reports have been documented [7,8,9] regarding the cytotoxicity of chlorhexidine digluconate (CHX) and Listerine to human gingival fibroblasts, but these are still common chemotherapeutic agents used for postoperative care of healing oral wounds. A study performed by Kozlovsky et al [4] reported that 1% CHX gel and Listerine solution increased the rate of epithelialisation of palatal wounds in a rat model. Similarly, Bassetti and Kallenberger [29] also reported that topical application of 0.1 and 0.2% CHX resulted in undisturbed healing on day 7 following injury.…”

“…Relatively large commensal flora and trauma from mastication impair the normal sequence of the healing process. Therefore, concern has been raised regarding the delayed healing of oral cavity wounds [4,5]. …”

“…Despite extensive efforts to improve wound healing, the outcomes of existing chemotherapeutic agents are far from optimal [6]. Moreover, studies [4,6] have also shown that chemotherapeutic agents like chlorhexidine (CHX), sodium hypochlorite, povidone-iodine and hydrogen peroxide have a cytotoxic effect on human oral epithelial and gingival fibroblast cells.…”

Antimicrobial activity of Calendula officinalis, Camellia sinensis and chlorhexidine against the adherence of microorganisms to sutures after extraction of unerupted third molars

“…Regarding the effects of mouthwashes on healing process, chlorhexidine, in a concentration-and time-dependent manner, affects negatively fibroblasts and keratinocyte cell proliferation in vitro and can impair wound healing 17,32 . Kozlovsky, et al 17 (2007) demonstrated that application of 0.1% and 0.2% chlorhexidine solution on an excisional wound in rats did not have a negative effect on the rate of wound closure.…”

“…Kozlovsky, et al 17 (2007) demonstrated that application of 0.1% and 0.2% chlorhexidine solution on an excisional wound in rats did not have a negative effect on the rate of wound closure. On the other hand, C. sinensis and C. officinalis showed potent wound healing activity.…”